DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6125 and Slc26a8

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_011244686.1	Gene:	Slc26a8 / 224661	MGIID:	2385046	Length:	1027	Species:	Mus musculus

Alignment Length:	495	Identity:	116/495 - (23%)
Similarity:	229/495 - (46%)	Gaps:	76/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FLSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAG--LSSEYGLYSAFIGSIIYVFFGTI 147
            ||.||..|. ::....||:||:::||..:||.:..:.|..  :......|:||..|:|||.||:.
Mouse   105 FLEWICLYRFKDWLLGDLLAGLSVGLVQVPQGLILSLLTRQLIPPLNVTYAAFCSSVIYVIFGSC 169

  Fly   148 PQVSIGPTSLMAILTLQFCADKP----------------------------VQVVIVLAFLAGLV 184
            .|:||||..|::.|.:....|:|                            :.:|....||.|::
Mouse   170 HQMSIGPFFLVSALMINVLKDRPFNNGHLILGTFVKDDFSVPTFYLSYNRSLSMVASTTFLTGII 234

  Fly   185 ELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVRIKGFPSIGDFFTNIRPTDAAM 249
            :|:||:..:||:.:::|...|.|:.:..||.::.||:..:||:.:........|..||
Mouse   235 QLSMGMLGMGFMATYLPEAATSAYLAAVALHIILAQMTCILGIMVSFHAGPISFIYNI------- 292

  Fly   250 GISCMVVLLSLRLLSQVNFKQDTPVTRRLKKILWYISISRNALVVFFTGLLVFIWVKKSSIEAVP 314
             |:..:.|......|.:.|.... |..|:.|.   |.|:.|...:.|...|:.|         :.
Mouse   293 -INYCIALPKANSTSILLFITSV-VALRINKC---IRITFNRYPIEFPMELLLI---------LG 343

  Fly   315 FA-LSSKVSSAMPTIK----LPPFAFEY-QNRTYVFTDILHELGSGIVVVPIVAVLANVAIAKAF 373
            |: |:||::.|....|    :.|::|.: :|..:   .||..:....:.:..|:....:::.|..
Mouse   344 FSLLTSKITMATENSKMLMNMIPYSFVFPENPEF---GILSRVVLQALSLSFVSSFLLISLGKKI 405

  Fly   374 VKDGN--LDASQEMLTLGLCNIAGSFFSAMPTCGAFTRSAVSQASGVRTPMAGIYTGLIVLSALS 436
            ....|  .:::|:::.:||||:..|||......|:.:|:.:...||.|...|.:....::|..:.
Mouse   406 ANFHNYRTNSNQDLIAIGLCNLLSSFFKCCVFTGSLSRTTIQDKSGGRQQFASLVGAGVMLLLMV 470

  Fly   437 ILTPYFQYIPKASLSAVLIAAVI-FMIDLAPVKELWQTNKKDFFSWVGSFIICLVAGVELGLLFG 500
            .:..:|..:|.|.|:.::::.|: ::..:..:..||:.::.:...|:.:|...::.|:::|||
Mouse   471 KMESFFHNLPNAVLAGIILSNVVPYLEAIYNLPSLWRQDQYECIIWMVTFSSAILLGLDVGLL-- 533

  Fly   501 IVLSMVFILLRLGNPKFEVTLKQHESTYYV-HIVPQSDVY 539
              :|:.|..       |.:|::.|.:...| ..:|.:::|
Mouse   534 --ISLAFTF-------FVITIRSHRTKILVLGQIPNTNIY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	115/494 (23%)
		HCO3_cotransp	108..462	CDD:304903	91/392 (23%)
		STAS	530..608	CDD:294402	3/11 (27%)
Slc26a8	XP_011244686.1	sulP	104..610	CDD:273284	116/495 (23%)
Slc26a8	XP_011244686.1	STAS_SulP_like_sulfate_transporter	<747..806	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289441at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820