DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6125 and slc26a6

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_001344243.4	Gene:	slc26a6 / 100005108	ZFINID:	ZDB-GENE-081105-83	Length:	747	Species:	Danio rerio

Alignment Length:	665	Identity:	161/665 - (24%)
Similarity:	286/665 - (43%)	Gaps:	156/665 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 ASKYSKPKEAHWLVRRIFFLSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGL 131
            |.:.:.||.....:..|..|:|:..|. ||.|..|||:||::|:..:||.:|||.||.:...:||
Zfish    46 AVRCTGPKAKSCFLSFIPLLAWLPKYPFRENAIGDLISGISVGIMHLPQGMAYALLAAVPPVFGL 110

  Fly   132 YSAFIGSIIYVFFGTIPQVSIGPTSLMAIL----TLQFCAD----------------------KP 170
            ||:|...:||..|||...:|:|..::|:::    |.:...|                      :.
Zfish   111 YSSFYPILIYFIFGTSKHISVGTYAVMSVMIGSVTERLAPDSDFTFPGNETNSTYIDFSSRDAER 175

  Fly   171 VQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVRIKGFPSI 235
            |::...:.||:|:.:|.:||.:.||:|:::..|:.:::|:..|:.|:.:|:|...|
Zfish   176 VKIAATVTFLSGIFQLLLGVVRFGFVVTYLSEPLVRSYTTAAAIHVIVSQLKYSFG--------- 231

  Fly   236 GDFFTNIRPTDAAMGISCMVVLLSL-RLLSQVNFKQDTPVTRRLKKILWYISISRNALVVFFTGL 299
                  |.|...:..:|.:..::.: .||.:.|.                     ..|||....:
Zfish   232 ------INPHRYSGPLSLIYTVIEICALLGKTNI---------------------GTLVVSIVTI 269

  Fly   300 LVFIWVKKSSIEAVPFALSSKVSSAMP----TIKLPPFAFEYQN-RTYVFTDILHELGSGI--VV 357
            :..|..|:.|..|     :.|:...:|    ||.:......|.: :|....:::.|:.||:  .|
Zfish   270 VGLIIAKELSALA-----AKKIPIPIPVELITIIIATVVSWYMDLKTIYKVEVVGEIPSGLQAPV 329

  Fly   358 VPIVAVLANV---AIAKAFVKDG---------------NLDASQEMLTLGLCNIAGSFFSAMPTC 404
            .|.|:.|.::   |.|.|.|..|               .:|::||::.|||.|..|..||.....
Zfish   330 APKVSQLGSMVGDAFALAVVGYGIAISLGRIFALKYAYKVDSNQELIALGLSNSIGGLFSCFAIS 394

  Fly   405 GAFTRSAVSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAVIFMI-DLAPVK 468
            .:.:||.|..::|.::.:||..:.|::|..|..:...|:.:|||.|:|::...:..|: ....:.
Zfish   395 CSMSRSMVQVSTGGKSQVAGAISALVILVILLKIGELFEELPKAVLAAIIYVNLQGMMKQFGDIC 459

  Fly   469 ELWQTNKKDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPKFEVTLKQHESTYYVHIV 533
            .||:|||.|...||.:.|:.::...::||...|..|::.::.|...||:.: |.|         :
Zfish   460 SLWRTNKVDMVVWVMTMILTILFNPDMGLAASIAFSILTVVFRTQLPKYSI-LGQ---------I 514

  Fly   534 PQSDVY-----YTGVDALR--SELRGACRLYHNDFPVVLDCARFMQFDATFSEMLISVAKEMASH 591
            |.:|:|     |..|..:.  :..|.:..||..:..        |..||.:.:..:.||| :.||
Zfish   515 PGTDIYKPVEDYNQVKEIPGITIFRSSATLYFANAE--------MYIDALYEKTGVDVAK-LLSH 570

  Fly   592 DVLLILQNMSLKVQQML----------------------PVMGNVRFCQEDSQLSSHLQVE---- 630
            ...  ||...|:.::..                      ||..:....:|:.:|.||.|..
Zfish   571 KKK--LQAKRLRKEKKAAKKAKKEAKKRAKEAARQAKEEPVFSDTEESEEEPELVSHSQTNGNVH 633

  Fly   631 -------KEAPVVEA 638
                   |:..||||
Zfish   634 ELSVKEPKDMVVVEA 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	147/615 (24%)
		HCO3_cotransp	108..462	CDD:304903	96/405 (24%)
		STAS	530..608	CDD:294402	19/84 (23%)
slc26a6	XP_001344243.4	sulP	63..729	CDD:273284	157/648 (24%)
slc26a6	XP_001344243.4	STAS_SulP_like_sulfate_transporter	<655..725	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810