DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp and TSPOAP1

DIOPT Version :9

Sequence 1:	NP_001189227.1	Gene:	Rbp / 41880	FlyBaseID:	FBgn0262483	Length:	1844	Species:	Drosophila melanogaster
Sequence 2:	NP_004749.2	Gene:	TSPOAP1 / 9256	HGNCID:	16831	Length:	1857	Species:	Homo sapiens

Alignment Length:	1950	Identity:	455/1950 - (23%)
Similarity:	692/1950 - (35%)	Gaps:	683/1950 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FPSANVEEENRRPEKAAAAASKKQKHKQQKSR--------------PRGSHSMP--------YES 48
            ||  ..||:.||.::..|..:...|..::::|              ||...|:.        ..:
Human   152 FP--ETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRA 214

  Fly    49 MHHHQSAAAAVAAGTTPNGMLDALSLQLRDAEMRRTEIERAHQETLAQIRNLSGSARPDAEAVEN 113
            ....::|:|.:|    .:..:.||..:.|:.:.|.|.:.:...:.| .:|:.....|..
Human   215 RDLSETASALLA----KDKQIAALQRECRELQARLTLVGKEGPQWL-HVRDFDRLLRES------ 268

  Fly   114 LQSRARELEKKVALENVRCEELQIELT----SALKAKQASRSACSGMGSVSSGGGATIPTSASSS 174
             |.....|::::||.|.| |.|.:..:    .||:|:                .||..|.:...:
Human   269 -QREVLRLQRQIALRNQR-ETLPLPPSWPPGPALQAR----------------AGAPAPGAPGEA 315

  Fly   175 TVTWAPTISHQDQGSEIDIIMAKIEQDNRV---------------------------LAELE-QP 211
            |        .|:....:.:|:.:.|::.||                           ..||| |.
Human   316 T--------PQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQL 372

  Fly   212 RTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAVLGGSGGGGGGVGGGGGGVSAL- 275
            |.:.:.:...:..:|.||.     |...|.::|.|....:..:||.:....          |||
Human   373 RQAQNENARLVEENSRLSG-----RATEKEQVEWENAELRGQLLGVTQERD----------SALR 422

  Fly   276 -SSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISA 339
             |.|..|..:||...|               .|....|.....:.
Human   423 KSQGLQSKLESLEQVL---------------KHMREVAQRRQQLE-------------------- 452

  Fly   340 LVPNSISGISSSLSSHAIQSMQYGTGQTSVE-----KLLSGTSGITGIPPLPVNIHTMKAMPTAL 399
             |.:..:.:|.......::.:|....:...|     :||..|            :.:|:|....|
Human   453 -VEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLEST------------LDSMQARVREL 504

  Fly   400 SQ--RGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLG 462
            .:  |...:.::|.:..:....|                         ||     |.||.
Human   505 EEQCRSQTEQFSLLAQELQAFRL-------------------------HP-----GPLDL----- 534

  Fly   463 STGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAALRQASKM 527
                           :|.|..          .|.||....||            ...::.|..:.
Human   535 ---------------LTSALD----------CGSLGDCPPPP------------CCCSIPQPCRG 562

  Fly   528 KMLDEIDIPLTRYNRSSPCS--PIPPNNWGLDEFT----DGLSVS----MMHNRGGLALGALDLD 582
            ....::|:|.....|.:|.|  |.|....|:...|    :.||.|    .:|| ...:....::|
Human   563 SGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHN-SPKSCPTPEVD 626

  Fly   583 TRNHGLNGASEPQVDMLDI--------PGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSL 639
            |.:.    ..|.:.|.:.:        .|..|..||:||:.|:|.:..||       ..|.||.|
Human   627 TASE----VEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEGPNE-------NPEAELPL 680

  Fly   640 CAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQC 704
            .||:|:.::.:.: :.|:.:.||:||||||||::||:|:..|||
Human   681 TAGEYIYIYGNMD-EDGFFEGELMDGRRGLVPSNFVERVSDDDL--------------------- 723

  Fly   705 DTTSLPSLPPHNPLLTHTH-EDLARL-----------------SETHTDLEHDQDDIS------- 744
                |.||||....|:|:. .:|:.|                 |:...:.|...|::|
Human   724 ----LTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSPSPEG 784

  Fly   745 ----DNVPAPKHLTLERQLNKSVLIGWS-PPEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIE 804
                ..||.|:.|.:.:||..||::.|. |||.|.   :..:|:.|:|.|:..:......:|::|
Human   785 LGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVE---LHGFHICVNGELRQALGPGAPPKAVLE 846

  Fly   805 GVDS-TRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSNH 868
            .:|. ..|..|||:::| :|.:|....|.:.:|. .|.:.||.:|...:|.:||.|:|:|.|||.
Human   847 NLDLWAGPLHISVQALT-SRGSSDPLRCCLAVGA-RAGVVPSQLRVHRLTATSAEITWVPGNSNL 909

  Fly   869 QHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQE-- 931
            .|.:.:|..|.....|..|..|...|.|.|.|:..|.|:.            ...|...||.|
Human   910 AHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQL------------PPQGPWEPGWERL 962

  Fly   932 EAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVN---RPTSTG-PVTGYAVYADGKK 992
            |...|...|.||..|.||.|.::|:|.||..|.::::|.||.   ..||.| .|||||:||||:|
Human   963 EQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQK 1027

  Fly   993 VTDINSPTGDHALIDIGKLGVFNP-RAVTIRTKSRDSQSADS---------APILIPNTV----- 1042
            :.::.|||....|:::.:|.:... |.|.:||.|...:||||         ||..:|..|
Human  1028 IMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLPARVSCPSP 1092

  Fly  1043 ------RNAVARRGPNQMGMG-PQLP-QGPHGMTVQQQMGGMPGQPGQQ---GQH---------- 1086
                  |..:|...|   |.| |..| |.|..:..|:..|..|..|.::   |.|
Human  1093 HPSPEARAPLASASP---GPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQE 1154

  Fly  1087 -----MMG------------GQQDHGQYDPNQMQQQQQ--------------------------- 1107
                 ::|            |::|.|...|:..:|:.:
Human  1155 EAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMC 1219

  Fly  1108 QQGQPGQPGHQPDA--------GSGLLGGL--------------------------LGG---LFS 1135
            |.|.||. |.:|.|        |..|:..|                          ||.   .|.
Human  1220 QGGDPGS-GLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQ 1283

  Fly  1136 KPTQ-NQVNQNGYQ----------------------PGQPGAQRGMVPIPGRPQGPQQQQQQPY- 1176
            |... |.:.:||.:                      |.|....:.:..||...:..::.:::..
Human  1284 KQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKS 1348

  Fly  1177 ---------GPQGP--------MGGPRFRGPVPGQLNMQGQQMQ-GQMQGQMQGQMQG---QMSG 1220
                     ||..|        .|.||    .|||..:..:..: |.....|.|.:.|   :..|
Human  1349 GAGCSSRDPGPPEPALLGLGCDSGQPR----RPGQCPLSPESSRAGDCLEDMPGLVGGSSRRRGG 1409

  Fly  1221 QMPGQMPGQMPGQMPGQMAGQMAGQMPGQMPGQM-PGQMSGQMPGQMMGPR-----------GP- 1272
            ..|.:.|.:.....|.:...::......|..|:: |.:..|.:| .:.|||           ||
Human  1410 GSPEKPPSRRRPPDPREHCSRLLSNNGPQASGRLGPTRERGGLP-VIEGPRTGLEASGRGRLGPS 1473

  Fly  1273 -------------------------LNQQQQQQQQMQQG------QMMPGQQAGQQQAQPGQPGQ 1306
                                     :....:.:|:...|      ...||.......|..|:|..
Human  1474 RRCSRGRALEPGLASCLSPKCLEISIEYDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRG 1538

  Fly  1307 P-----GQMP--------------------GAQKKP----------------------------- 1317
            |     |..|                    |..|:|
Human  1539 PPKANSGPKPYPRLPAWEKGEPERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVL 1603

  Fly  1318 ------------------------RYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDA 1358
                                    |.|||:|||||.:||||||..:|||||:||..:||||||||
Human  1604 RPSTAELVPARSPSETLAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDA 1668

  Fly  1359 DGFYWGELRGRRGYVPHNMVSEVEDTTASMTAGGQ---MPGQMPGQM---GQGQGVGVGGTAQVM 1417
            ||||.||..||.||:|.|||:||   .....||.|   ..|.:...:   |.|.|..|..||..
Human  1669 DGFYQGEGGGRTGYIPCNMVAEV---AVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHT- 1729

  Fly  1418 PGQGAPQQSMRNVSRDRWG---------------DIYANMPVKRMIALYDYDPQELSPNVDAEQV 1467
              .|.|.:..|:...:..|               |:.|   ...|:|.:||:|||.|||:|.| .
Human  1730 --TGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKA---PHSMVAAFDYNPQESSPNMDVE-A 1788

  Fly  1468 ELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAPDQYNNQMGPGGVAGRGGLSQRGR 1532
            ||.|:.|::|.|:|.||:||||.|||:|.|||||||||.          |||..|  |||.:..|
Human  1789 ELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLE----------GPGPEA--GGLDREPR 1841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	28/67 (42%)
		FN3	748..822	CDD:238020	24/75 (32%)
		FN3	844..907	CDD:238020	23/62 (37%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	43/60 (72%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	38/60 (63%)
TSPOAP1	NP_004749.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..321		11/61 (18%)
		SPEC	332..524	CDD:295325	40/254 (16%)
		Tropomyosin_1	350..507	CDD:289488	35/219 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..629		16/64 (25%)
		SH3_RIM-BP_1	657..717	CDD:212947	28/67 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..789		9/59 (15%)
		FN3	885..947	CDD:238020	23/61 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1083..1311		40/231 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1330..1479		29/153 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1501..1601		13/99 (13%)
		SH3_RIM-BP_2	1629..1690	CDD:212945	43/60 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1723..1761		7/40 (18%)
		SH3_RIM-BP_3	1768..1828	CDD:212946	38/70 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1823..1857		11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147759
Domainoid	1	1.000	198	1.000	Domainoid score	I3075
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1808
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40612
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14234
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5407
SonicParanoid	1	1.000	-	-		X2282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.980