DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp and RIMBP3

DIOPT Version :9

Sequence 1:	NP_001189227.1	Gene:	Rbp / 41880	FlyBaseID:	FBgn0262483	Length:	1844	Species:	Drosophila melanogaster
Sequence 2:	NP_056487.1	Gene:	RIMBP3 / 85376	HGNCID:	29344	Length:	1639	Species:	Homo sapiens

Alignment Length:	1635	Identity:	354/1635 - (21%)
Similarity:	571/1635 - (34%)	Gaps:	442/1635 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSANVEEENRRPEKAAAAASKK--------------QKHKQQKSRPR---GSHSMPYE------- 47
            |.|:..||.......:...|::              ..|: :.|.||   ||.|.|.|
Human   303 PKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHR-KLSNPRGGEGSESQPCEVLTPSPP 366

  Fly    48 SMHHHQ--------SAAAAVAAGTTPNGMLDALSLQLR--------DAEMRRTEIERAHQETLAQ 96
            .:.||:        :.|..|.|.....  |.|.:.|||        |.:::|.:::||
Human   367 GLGHHELIKLNWLLAKALWVLARRCYT--LQAENKQLRRAGCPYQADEKVKRLKVKRA------- 422

  Fly    97 IRNLSGSARPDAEAVENLQSRARELEKKVALENVR----------CEELQI-ELTSALKAKQASR 150
              .|:|.||       .|..|||:|::    .|:|          |..|:: ::.:..:|:..|.
Human   423 --ELTGLAR-------RLADRARKLQE----TNLRAVSAPIPGESCAGLELCQVFARQRARDLSE 474

  Fly   151 SACSGMGS-----------------VSSGGGATIPTSASSSTVTWAPTISHQDQGSEIDIIMAKI 198
            .|.:.:..                 |:||..:.:.|........|...       .::|.:.
Human   475 QASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNV-------RDLDRLQ--- 529

  Fly   199 EQDNRVLAELEQPRTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAV--LGGSGGG 261
            .:..|.:..|::.......:..|.|.:...|....|.|. ....||.||::.:|..  ||..
Human   530 RESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR-QMLALERELDQRRRECQELGAQ--- 590

  Fly   262 GGGVGGGGGGVSALSSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVV 326
                     ...|...|..:..|..|:.|.|...:..      .....|.......|.|.:..|.
Human   591 ---------AAPARRRGEEAETQLQAALLKNAWLAEE------NGRLQAKTDWVRKVEAENSEVR 640

  Fly   327 GGGGQGGLSSISALVPNSISGISSSLSSHAIQSMQYGTGQTSVEKL-LSGTSGITGIPPLPVNIH 390
            |..|:       |......||:   ::...:|  |...||...::| ......:..:.|....|.
Human   641 GHLGR-------ACQERDASGL---IAEQLLQ--QAARGQDRQQQLQRDPQKALCDLHPSWKEIQ 693

  Fly   391 TMKAMPTALSQRGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLL 455
            .::..|      |.......:::.||...:.....|.                 .|....:..:.
Human   694 ALQCRP------GHPPEQPWETSQMPESQVKGSRRPK-----------------FHARPEDYAVS 735

  Fly   456 DTGTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPF---T 517
            .....:.....:.|...|.                     .||.|...|.:.....||.|.   |
Human   736 QPNRDIQEKREASLEESPV---------------------ALGESASVPQVSETVPASQPLSKKT 779

  Fly   518 AAALRQASKMKMLDEIDIPLTRYNRSSPCSPIPPNNWGLDEFT----DGL---SVSMMHNRGGLA 575
            ::....:|:..|...:           |.||.      ||..|    |.|   |||:....||.|
Human   780 SSQSNSSSEGSMWATV-----------PSSPT------LDRDTASEVDDLEPDSVSLALEMGGSA 827

  Fly   576 LGALDLDTRNHGLNGASEPQVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLC 640
                                     .|...:..:|:|::.|:|.:..|:       ..||||.|.
Human   828 -------------------------APAAPKLKIFMAQYNYNPFEGPND-------HPEGELPLT 860

  Fly   641 AGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCD 705
            ||||:.::...: :.|:.:.||.||||||||::||:                          |..
Human   861 AGDYIYIFGDMD-EDGFYEGELEDGRRGLVPSNFVE--------------------------QIP 898

  Fly   706 TTSLPS-LPPHNPLLTHTHEDLARLSETHTDLEHDQDDISDNVPAPKHLTLERQLNKSVLIGWSP 769
            .:.:|. ||..:|                 ||...|      :||.:...||..   |:|.|
Human   899 DSYIPGCLPAKSP-----------------DLGPSQ------LPAGQDEALEED---SLLSG--- 934

  Fly   770 PEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDS-TRPHRISVRSVTQNRQTSRDAACTM 833
                      .....||..|...|:...:|....|.:|: |...::.:......:..||....|
Human   935 ----------KAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGT- 988

  Fly   834 IIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPST 898
               :....:.|..:...::|.:||.|:|:.::..|.|||.:::.|......|:..:|..||.|.|
Human   989 ---KGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGT 1050

  Fly   899 QYRVTVRAKHLRAVGQ-HAANVGQTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQEIQLEAGPQD 962
            .||..|..:..|.:.| :...:..|               ..|.||..|.|.||.::.:|.....
Human  1051 HYRARVEVRLPRDLLQVYWGTMSST---------------VTFDTLLAGPPYPPLDVLVERHASP 1100

  Fly   963 GTILVTWQPV---NRPTSTG-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGV-FNPRAVTIR 1022
            |.::|:|.||   :..:|.| .||||||||||.||.::...|....|::..:|.| ...:.|::|
Human  1101 GVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVR 1165

  Fly  1023 TKSRDSQSADSAPILIPNTVRNAVARRGPNQMGMG-----PQ-----LPQGPHGMTVQQQMG-GM 1076
            |.|...:|.||.|..||...  .:..|.|......     |.     .|..|..:::..... ..
Human  1166 TMSLCGESLDSVPAQIPEDF--FMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKAS 1228

  Fly  1077 PGQPGQQGQHMMGGQQDHGQYDPNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGG--------- 1132
            |..||..|:......:...:..|    ::|......|..|..|.:|:|.....|..
Human  1229 PHNPGSCGEPQAKFLEAFFEEPP----RRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDL 1289

  Fly  1133 LFSKPTQNQVNQNGYQPGQPGAQRGMVPIPGRPQGPQQQQQQPYGPQGPMGGPRFRGPVPGQLNM 1197
            ||.|..||      ::|.....|      ||..:...|.          ||  ..:.|.||.:::
Human  1290 LFQKSPQN------HRPPSVSDQ------PGEKENCSQH----------MG--TSKSPAPGFIHL 1330

  Fly  1198 QGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMPGQMAGQMAGQMPGQMPGQMPGQMSGQM 1262
            :.:....:...|.:..::..:..:...|      |..|.|:....      |........:..:.
Human  1331 RTECGPRKEPCQEKAALERVLRQKQDAQ------GFTPPQLGASQ------QYASDFHNVLKEEQ 1383

  Fly  1263 PGQMMGPRGPLNQQQQQQQQ--MQQGQMMPGQQAGQQQAQP-----------------GQPGQPG 1308
            ....:...|...::::::.:  .:|||.: |.:.|.|..:|                 |.|.|.|
Human  1384 EALCLDLWGTERREERREPEPHSRQGQAL-GVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLG 1447

  Fly  1309 QMPGAQKKPRYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYV 1373
              .||....|.|||:.||:|..||.|....:|||.||:...::|:|.:|...||..|...:.|.:
Human  1448 --TGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNI 1510

  Fly  1374 PHNMVSEVEDTTASMTAGGQMP--GQMP--GQMGQGQGVGV-GGTAQVMPGQGAPQQSMRNVSRD 1433
            |..:|:|:|..|.......:.|  |.:|  ..:...||:.: .|::.|:.|         |..|
Human  1511 PGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQG---------NSKR- 1565

  Fly  1434 RWGDIYANMPV---KRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYMGELDG 1495
                    :|:   |.|||..||||.:.......:. .|..:.|::::|||.||:.|||.|||.|
Human  1566 --------LPLWTPKIMIAALDYDPGDGQMGGQGKG-RLALRAGDVVMVYGPMDDQGFYYGELGG 1621

  Fly  1496 VRGLVPSNFL 1505
            .|||||::.|
Human  1622 HRGLVPAHLL 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	27/67 (40%)
		FN3	748..822	CDD:238020	15/74 (20%)
		FN3	844..907	CDD:238020	20/62 (32%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	23/60 (38%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	27/60 (45%)
RIMBP3	NP_056487.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		GBP_C	<75..139	CDD:303769
		coiled coil	106..117	CDD:293879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..364		14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..811		24/174 (14%)
		SH3_RIM-BP_1	836..895	CDD:212947	26/66 (39%)
		fn3	995..1056	CDD:278470	19/60 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1273		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1292..1330		13/61 (21%)
		SH3	1456..1517	CDD:302595	23/60 (38%)
		SH3_RIM-BP	1573..1633	CDD:212785	27/60 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14234
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940