Protein Alignment Rbp and rimbp2

DIOPT Version :10

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_031758268.1
• Gene: rimbp2 / 780347
• XenbaseID: XB-GENE-994108
• Length: 1864
• Species: Xenopus tropicalis
• Alignment Length: 1922
• Identity: 438/1922 - (22%)
• Similarity: 691/1922 - (35%)
• Gaps: 612/1922 - (31%)

  Fly    12 EEENRRPEKAAAAASKKQKHKQQKSRPRGSHSMPYESMHHHQSAAAAVAAGTTPNGMLDALSLQL 76
            |:|.:||:|..::...::..|.|..|....::         :.|.|.|:..|.......|.|.:
 Frog   152 EKEKKRPQKPESSKVGERASKLQGQRAPTKNT---------EKANAPVSTKTKQKKTSSASSAK- 206

  Fly    77 RDAEMRRTEIERAHQETLAQIRNLSGSARPDAEAVENLQSRARELEKKVALENVRCEELQIELTS 141
                      ..:.::|:..:  :.|...|..      .|:..|.|.::.|..|.|:||:..| .
 Frog   207 ----------RPSTKQTMRSV--IGGPGHPPC------PSKDSEREVEIRLLQVECDELRNRL-G 252

  Fly   142 ALK--------------AKQASRSAC---SGMGSVSSGGGATI--PTSASSSTVTWAPTISHQDQ 187
            .||              .:|:.:...   ..:..:|:||.|.|  |....:......|::.|:..
 Frog   253 CLKEGLMGQKPSDVEQLLRQSQKELLWLQRQLSFISNGGPACILSPNKFRNDLQCLPPSVQHRSY 317

  Fly   188 GSEIDIIMAK--------------------IEQDNRVLAELEQPRTSASASMSALPPSSML-STV 231
             |.|..:..|                    :|.:   |.::.|.::..|...::|...::| ..|
 Frog   318 -SHIQFLEEKSRPFKSDVTSVSPEKLHWNFLEDE---LKDVVQDKSRLSLQYASLSHRALLYDQV 378

  Fly   232 NSEFRTISKSEL----EEEL---NRYKRAVLGGSGGGGGGVGGGGGGVSALSSGYSSLPQSLAST 289
            .|::..:.::.:    |.:|   .:|:                       |.:...:|.|.|
 Frog   379 KSDYEQLRETLVIVTRERDLAVKEKYQ-----------------------LQAKLENLEQVL--- 417

  Fly   290 LPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISALVPNSISGISSSLSS 354
                            .|...||.....:....        :..|:.::|             ..
 Frog   418 ----------------KHMREAAERRQQLELEH--------EQALAVLNA-------------KQ 445

  Fly   355 HAIQSMQYGTGQTSVE-----KLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTIQLYNLQSTT 414
            ..|..:|....:..:|     :||..|            :.:|:|....|.::     ...||..
 Frog   446 QEIDLLQKAQVEAKIEHEGAVQLLENT------------LDSMQAKVRELEEK-----CRTQSEQ 493

  Fly   415 MPLLSLNSHNL-PPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLGSTGLSGLGVGPSVGGI 478
            ..|||...... ..||.....:..|||  .|..|...|..|..                 .:.||
 Frog   494 FNLLSRELEKFRQQAGKIDLLSGNAGG--VLDFPGSPNKTLTQ-----------------FINGI 539

  Fly   479 TGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAALRQASKMKMLDEIDIPLTRYNRS 543
              |||:...:....|:..:.|.|..| |.:.....                 :::.:..|..:||
 Frog   540 --ATSISKGNESPTGSRSVISEYIRP-LQITGDKP-----------------EQLCVKPTFLSRS 584

  Fly   544 SPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEPQVDMLDIPGKGRCC 608
            ...||           ..|...:|               .:....|.:.:      ...||...|
 Frog   585 RSGSP-----------RRGFECNM---------------DKEQNTNTSKQ------RYSGKVHLC 617

  Fly   609 VFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPAS 673
              |||:.|:|.|..||       ..|.||.|.||.||.|:...: :.|:.:.|||||:|||||::
 Frog   618 --IARYSYNPFDGPNE-------NPEAELPLVAGKYLYVYGDMD-EDGFYEGELLDGQRGLVPSN 672

  Fly   674 FVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCDTTSL----------PSLPPHNPLLTHTHEDLAR 728
            ||..:..|   |||.:  |||...::.::...:..|          ||:...:.:|.
 Frog   673 FVDFVQND---EFHMS--STLASEQEENILNHSAPLLQSELKLEITPSIHMESSVLN-------- 724

  Fly   729 LSETHTDLEHDQDDI-SDNVPAPKHLTLERQLNKSVLIGWSPP-EPVGYNLIDSYHVYVDGVLKV 791
             :.|.|.::.:.|:| .|.||.|:.:||.:||.|||::||.|| .|.|:..|.||:|.:...::.
 Frog   725 -NGTGTTMDVNIDEIGEDIVPYPRKITLIKQLAKSVIVGWEPPLVPPGWGTIHSYNVLIGKEIRA 788

  Fly   792 TVKANERTRALIEGVD-STRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCS 855
            |:....||:.|:|.:| :|..:|:|:::|| :|..|.:..|::::|:|.. :.|:.::..:||..
 Frog   789 TLNFGSRTKLLLEKLDLATVTYRLSIQTVT-DRGNSDELQCSLLVGKDVI-VAPTHLKVDNITPM 851

  Fly   856 SAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVG 920
            ||.:.|||:|||:.||:.:|:.|...||...||:....|.|:..|:|.:.||..:...|....
 Frog   852 SAELIWLPSNSNYSHVIFLNDEEYDIVKAASYRYHFFNLKPNMTYKVKLLAKPHQMPWQLPLE-- 914

  Fly   921 QTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQ-PVNRPTST---GPV 981
                     |.|...||.:|.||..|.|.||..:.:..||...|:||||: ||..||.|   ..|
 Frog   915 ---------QRERKEAYTEFTTLPSGPPIPPDNVIVHQGPTPVTLLVTWKPPVLSPTGTSNGAHV 970

  Fly   982 TGYAVYADGKKVTDINSPTGDHALIDIGKLGVFNPRAVTIRTKSRDSQSADSAPILIP------- 1039
            ||::|||.|:||.::..|..::.::|:.||...:.:.||:||.|...:|.||...|||
 Frog   971 TGFSVYARGQKVAEVVFPAAENIVVDLLKLLNLDAKEVTVRTLSAQGESEDSISALIPPDLMVPP 1035

  Fly  1040 ------------------------------------NTVRNAV-------------------ARR 1049
                                                ...|.|.                   .||
 Frog  1036 IQHPRTMPKCKPLATAGVPDTKDDHVCPHRKVDESWEHTRTASPVHGHTLEPPTSNFHSPVHGRR 1100

  Fly  1050 GPNQMGMGPQLPQG-PHGMTVQQQMGGMPGQ---------------PGQQGQHMMGGQQDHGQYD 1098
            .|:...:.|| ||| |...|:.:.|.....|               ......|.....::...||
 Frog  1101 SPSPQRILPQ-PQGAPVSNTMAKAMAREAAQRVAESTRNEKRSLFSERSNSVHYANSDEEEDGYD 1164

  Fly  1099 PNQMQQQ--------------QQQQGQPGQPGHQPDAGSGLLGGLL---------------GG-- 1132
            ...::::              :|....||:..|...:....|..:|               ||
 Frog  1165 SPHIKRKGASVDEFLKGSELGKQSHYCPGEDYHTESSRGSDLSDILEEDEEELYSEMQLEDGGRR 1229

  Fly  1133 -------------------------------------LFSKP--------TQNQVNQNGYQPGQP 1152
                                                 |||.|        ..:::...|...|..
 Frog  1230 RVSITSHNTLKCSKTSTTDPALKEQLDYSPQHHHSKKLFSIPEVAEEEGGEHSELLHRGCSIGIT 1294

  Fly  1153 GAQRGMVP----IP------GRPQGPQQQQQ----------QPYGPQGPMGGPRFRGPVPG-QLN 1196
            ...||.:.    ||      ||.|.|....:          :.:..:|...|...|.|..| ...
 Frog  1295 YKTRGALASVNRIPRAGSREGRHQSPWHLSKARFNGTPTYSEDFTTEGSKLGSLSRSPDSGLDCG 1359

  Fly  1197 MQGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMPGQMA-----------GQMAG------ 1244
            .:.::.:...:.....:...|.:.|.| ..|..:...:..:..           |.|:.
 Frog  1360 SEEEEARCNYRKATVARNAAQENPQNP-PCPRDLKQMLTRRKTLTRQSSVEEDFGDMSAGFVDNK 1423

  Fly  1245 -------QMPGQMP--------------------------------------GQMP--------- 1255
                   :|..|.|                                      |..|
 Frog  1424 SNIKHQPEMHEQQPCIRDLNNISARKTDFYQKDHRDAVLRPPHRDTENSLLLGNHPTLSRTDHQT 1488

  Fly  1256 -----GQMSGQMPGQMMGPRGPL----NQQQQQQQQMQQGQMMPGQQAGQQQAQPG------QP- 1304
                 |..:.|.|..||.|...:    |.:..:.:...:|.:.|.::....::..|      ||
 Frog  1489 RRFSHGSAAPQRPRPMMVPSIEITMDSNSEGGRSRSGSEGNISPVKEEAYYRSLGGHRKWSLQPT 1553

  Fly  1305 ----------GQPGQMP---------GAQKKP-RYFVAMFDYDPSTMSPNPDGCDEELPFQEGDT 1349
                      |...|:.         |.:..| |.|||:|||||.|||||||..:|||||:||..
 Frog  1554 RVSDDRYDSYGSREQLSMYEESETDGGMEDFPARIFVALFDYDPRTMSPNPDAAEEELPFKEGQV 1618

  Fly  1350 IKVFGDKDADGFYWGELRGRRGYVPHNMVSEV----EDTTASMTAGGQMPGQMPGQMGQGQGVGV 1410
            |||:||||:||||.||...|.|::|.|||||:    |:....:...|.:|...|
 Frog  1619 IKVYGDKDSDGFYRGETCERAGFIPCNMVSEIQVDDEEMMEQLFKQGFLPLNTP----------- 1672

  Fly  1411 GGTAQVMPGQGAPQQSMRNV---------SRDRWGDIYANMPVKRMIALYDYDPQELSPNVDAEQ 1466
               .:.:......::|.|:|         .|:|......::..:||:|||||||:|.|||||.|
 Frog  1673 ---VEKIVNCERFKESSRSVHRRSRKSKRERNRRSGRQHSVTTRRMVALYDYDPRESSPNVDVE- 1733

  Fly  1467 VELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAPDQYNNQMG------PGGVAGRG 1525
            .||.|.||:|:.|:|::||||||.|||:|.:||||||||.:.||.....:.      |.....|.
 Frog  1734 AELTFCTGDILNVFGEIDEDGFYYGELNGHKGLVPSNFLEEVPDDVEVYLSDTPSRYPQDTPMRT 1798

  Fly  1526 GLSQ-RGRGQGPGARGPPPPPRDNMM--PGMGGRGQP 1559
            .:.: .....|...|.|.|....:.|  |...|.|.|
 Frog  1799 KVKRVPSENTGTPRRAPSPTVHLHSMSPPSSMGSGSP 1835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	COG4913	<69..>148	CDD:443941	16/92 (17%)
		SH3	609..677	CDD:473055	30/67 (45%)
		FN3	748..822	CDD:238020	30/75 (40%)
		COG3979	844..>1004	CDD:443178	59/163 (36%)
		FN3	844..907	CDD:238020	23/62 (37%)
		Med15	<1050..>1272	CDD:312941	57/410 (14%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	41/60 (68%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	42/60 (70%)
rimbp2	XP_031758268.1	Mitofilin	109..>485	CDD:430783	69/440 (16%)
		Smc	<342..>508	CDD:440809	34/248 (14%)
		SH3_RIM-BP_1	616..676	CDD:212947	31/69 (45%)
		fn3	839..902	CDD:394996	23/62 (37%)
		FN3	933..1024	CDD:238020	36/90 (40%)
		SH3_RIM-BP_2	1588..1649	CDD:212945	41/60 (68%)
		SH3_RIM-BP_3	1714..1774	CDD:212946	42/60 (70%)