DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rbp and rimbp2b

DIOPT Version :10

Sequence 1:NP_001189227.1 Gene:Rbp / 41880 FlyBaseID:FBgn0262483 Length:1844 Species:Drosophila melanogaster
Sequence 2:XP_009302494.1 Gene:rimbp2b / 563166 ZFINID:ZDB-GENE-040724-96 Length:1723 Species:Danio rerio


Alignment Length:1479 Identity:346/1479 - (23%)
Similarity:532/1479 - (35%) Gaps:507/1479 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   453 GLLDTGTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFT 517
            |.||   :|.|:.|:|   |.|.|..|...:|..|..|.....|.|:.      |..|..|....
Zfish   298 GKLD---ILSSSQLTG---GDSPGSPTKPLTLSQLLNGLTAPSGKGNE------DSMSKISELIR 350

  Fly   518 AAALRQASKMKMLDEIDIPLTRYNRSSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLD 582
            ...:.:..|:::|   .:..:..:||:|.|   |....|.|....::.:|....|          
Zfish   351 PLQMTEGEKVELL---SVKPSFLSRSTPSS---PRRAFLSEVRPVIATAMDKELG---------- 399

  Fly   583 TRNHGLNGASEPQVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLV 647
                     |.|: ......||.|.||  ||:.|:|.|..||       ..|.||.|.||.||.|
Zfish   400 ---------SSPR-SKSRYTGKVRLCV--ARYNYNPYDGPNE-------HPEAELPLVAGKYLYV 445

  Fly   648 WTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRD--AEDGSMQCDTTSLP 710
            :.:.: :.|:.:.|||||::||||::||      |.::..:...:.|.|  .|...:.....|:|
Zfish   446 YGTMD-EDGFYEGELLDGQQGLVPSNFV------DFVQDEELPSAPLLDRIKEPSYLNHSPASMP 503

  Fly   711 S--LPPHNPLLTHTHEDLARLSETHTD----------------------------LEHDQDDI-S 744
            |  :...:.||:...:.|...:.|.|.                            |:.:.|:| .
Zfish   504 SSAVSTLSTLLSEKLDALGSGTGTGTSSSSGVSSLGMSTGLGIDYLGPCSNGTGTLDVNIDEIGE 568

  Fly   745 DNVPAPKHLTLERQLNKSVLIGWSPPEPV-GYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDS 808
            |.||.|:.:||.:||.|||:|.|.||..: |:..|..|:|.||..:::::....||::|||.::.
Zfish   569 DIVPYPRRITLIKQLAKSVIISWDPPVVLPGWTPISGYNVLVDQEVRMSIPFGGRTKSLIEKLNL 633

  Fly   809 T-RPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVV 872
            | ..||||::|:|: |..|....||:::|:|.. :.|..:|..:||.:||.::|:|:|||:.|::
Zfish   634 TVCTHRISIQSMTE-RGLSDPLRCTLLVGKDVV-VAPYYLRVENITQASAELTWMPSNSNYSHMI 696

  Fly   873 CVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQ---------TGGAGRP 928
            .:|:||...||||.|::....|.|.|.|::.|.|:..:...|......:         |..|.|.
Zfish   697 YLNDVEYDVVKPGGYKYHFYNLKPMTVYKIRVVARPHQMPWQLPLEQREKKEVSVEFCTQPAARH 761

  Fly   929 GQEEAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVNRPTST-------GPVTGYAV 986
            ...:.|.........:.|.|.|||::|::.|...|.:.:.|:|   ||.|       ..|.||.|
Zfish   762 AFLQKPEVGTSRLNCSSGPPLPPQDVQVQLGQTPGVLQIRWKP---PTLTPNGTSNGASVMGYIV 823

  Fly   987 YADGKKVTDINSPTGDHALIDIGKLGVFNPRAVTIRTKSRDSQSADSAPILIPNTV--------- 1042
            :..|:|:.:|..||.|...:::.::.....|.|.:||.|...:|.||....||:::         
Zfish   824 FTKGQKIAEIMHPTADFVTVELNRIQCLEAREVIVRTISAQGESQDSPVATIPHSLLVPHPHGHL 888

  Fly  1043 ---RNAVARRGPNQMGMGPQLPQ---GPHGM---------------------------------T 1068
               .:......|......|..||   .||.|                                 .
Zfish   889 HLQSHPQTHPPPYPQAYPPTHPQPHVQPHSMPPSHPHPQPHIHPPHSSYPMSKPKLLPSARDPHA 953

  Fly  1069 VQQQMGGMPGQPGQ---------------------------------------QG---------- 1084
            .:.:||...|||.:                                       ||          
Zfish   954 KESEMGRRMGQPWEPHPRAPSPLPHHSHHGHTLEPPHVEGRRSPSPQRILPQPQGVPIPNTVARA 1018

  Fly  1085 ---------------------------QHMMGGQQDHGQYDP----------------------- 1099
                                       .|.:...::...||.                       
Zfish  1019 MARQAAQRNAPNSRVERRNIFSDRGNALHSLNSDEEEEGYDSPHARRKGASVDEFLRGSELGRHH 1083

  Fly  1100 -------------------------------NQMQQQQQ-------------------------- 1107
                                           ::||.::.                          
Zfish  1084 HHYSHSDEYYTESSRGSDLSDIMEEDEEELYSEMQLEEGRRRSINSHNTLKAYYRRQDLAVERDS 1148

  Fly  1108 -------------------------------------------QQGQPG------QPGHQ----- 1118
                                                       ::.:||      :|.||     
Zfish  1149 WDLQREVVRQRSLRSHKRLHSIPEVAEEDPDTGVEVMGQRLRFEEARPGTPCRSPRPYHQDSRQS 1213

  Fly  1119 ------------------------------------------PDAG-------SGLLG------G 1128
                                                      ||:|       .|.||      .
Zfish  1214 NHLSPSKCVRRLQRQRSSPRYTSIEERPPCWSSSSSRQTTKSPDSGLDCGSEEEGSLGYRGGYHS 1278

  Fly  1129 LLGG----LFSKPTQNQVNQNGYQPGQPGAQRGMV-------------------PIPGRPQGPQQ 1170
            .:||    :.|.|....::..|     |..:|.:.                   .||......:.
Zfish  1279 YMGGSPLRVGSGPNMRLIHSEG-----PVERRALAAGRKRTLTRQCSVEEDFLDAIPETRSMRES 1338

  Fly  1171 QQQQPYGPQGPMGGPRFRGPVPGQLNMQGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPG--- 1232
            .....|.|.......|||.  .|:|:..|:.....::.....::...|...:   :.|..|.   
Zfish  1339 YHHYHYHPHHHHPQRRFRS--EGRLSEVGRTYHRDIRAYSVARLNRAMDEPL---ILGSSPSTGR 1398

  Fly  1233 ----QMPGQMAGQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLN--QQQQQQQQMQQGQMMPG 1291
                ...|:..|.  |..|.|........:...|.....|..|.|:  :.......:...:..|.
Zfish  1399 SDRLDHSGRRTGH--GCPPAQRRPMTVPSIEITMENNSEGSEGNLSPIKDDVYYTNVAHRRKWPA 1461

  Fly  1292 QQA-------GQQQAQPG-QPGQPGQMPGAQKKPRYFVAMFDYDPSTMSPNPDGCDEELPFQEGD 1348
            |:.       |:::..|. ...:|..:      .|.|||||||||.:||||||...|||||:||.
Zfish  1462 QRTEHRYDGYGRERRSPDYYESEPEDL------SRIFVAMFDYDPLSMSPNPDAAVEELPFKEGQ 1520

  Fly  1349 TIKVFGDKDADGFYWGELRGRRGYVPHNMVSEV----EDTTASMTAGGQMPGQMPGQMGQGQGVG 1409
            .|||||:||.||||..|:.||||.||.|||||:    ::....:...|.:|...|.:.       
Zfish  1521 IIKVFGEKDTDGFYRAEICGRRGLVPCNMVSEIQTDDDEMMDQLLKQGFLPLNTPIEK------- 1578

  Fly  1410 VGGTAQVMPGQGAPQQSMRNVSRD---RWGDIYANMPVKRMIALYDYDPQELSPNVD-------- 1463
            :....:...|:...::| |...|:   |.|..:| :..:||:|||||||:|.|||||        
Zfish  1579 IVNCNRFKDGRSVNRRS-RKSKRERNKRSGRQHA-VSTRRMVALYDYDPRESSPNVDVEARYGGS 1641

  Fly  1464 --AEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAPD 1510
              :|:.||.|..|::|.|:|::||||||.|||:|.:||||||||.:.||
Zfish  1642 LQSEEAELTFCAGDVITVFGEIDEDGFYYGELNGHKGLVPSNFLEEVPD 1690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RbpNP_001189227.1 COG4913 <69..>148 CDD:443941
SH3 609..677 CDD:473055 29/67 (43%)
FN3 748..822 CDD:238020 31/75 (41%)
COG3979 844..>1004 CDD:443178 54/175 (31%)
FN3 844..907 CDD:238020 25/62 (40%)
Med15 <1050..>1272 CDD:312941 57/552 (10%)
SH3_RIM-BP_2 1319..1380 CDD:212945 43/60 (72%)
SH3_RIM-BP_3 1446..1507 CDD:212946 41/70 (59%)
rimbp2bXP_009302494.1 Smc <70..>309 CDD:440809 5/13 (38%)
SH3_RIM-BP_1 414..474 CDD:212947 30/75 (40%)
FN3 667..731 CDD:238020 25/63 (40%)
PRK10263 <866..>1012 CDD:236669 19/145 (13%)
SH3_RIM-BP_2 1491..1552 CDD:212945 43/60 (72%)
SH3_RIM-BP_3 1616..1687 CDD:212946 41/70 (59%)
Blue background indicates that the domain is not in the aligned region.

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