DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp and RIMBP3B

DIOPT Version :9

Sequence 1:	NP_001189227.1	Gene:	Rbp / 41880	FlyBaseID:	FBgn0262483	Length:	1844	Species:	Drosophila melanogaster
Sequence 2:	NP_001122107.1	Gene:	RIMBP3B / 440804	HGNCID:	33891	Length:	1639	Species:	Homo sapiens

Alignment Length:	1639	Identity:	357/1639 - (21%)
Similarity:	572/1639 - (34%)	Gaps:	450/1639 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSANVEEENRRPEKAAAAASKK--------------QKHKQQKSRPR---GSHSMPYE------- 47
            |.|:..||.......:...|::              ..|: :.|.||   ||.|.|.|
Human   303 PKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHR-KLSNPRGGEGSESQPCEVLTPSPP 366

  Fly    48 SMHHHQ--------SAAAAVAAGTTPNGMLDALSLQLR--------DAEMRRTEIERAHQETLAQ 96
            .:.||:        :.|..|.|.....  |...:.|||        |.:::|.:::||
Human   367 GLGHHELIKLNWLLAKALWVLARRCYT--LQEENKQLRRAGCPYQADEKVKRLKVKRA------- 422

  Fly    97 IRNLSGSARPDAEAVENLQSRARELEKKVALENVR----------CEELQI-ELTSALKAKQASR 150
              .|:|.||       .|..|||||::    .|:|          |..|:: ::.:..:|:..|.
Human   423 --ELTGLAR-------RLADRARELQE----TNLRAVSAPIPGESCAGLELCQVFARQRARDLSE 474

  Fly   151 SACSGMGS-----------------VSSGGGATIPTSASSSTVTWAPTISHQDQGSEIDIIMAKI 198
            .|.:.:..                 |:||..:.:.|........|...       .::|.:.
Human   475 QASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNV-------RDLDRLQ--- 529

  Fly   199 EQDNRVLAELEQPRTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAV--LGGSGGG 261
            .:..|.:..|::.......:..|.|.:...|....|.|. ....||.||::.:|..  ||..
Human   530 RESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR-QMLALERELDQRRRECQELGTQ--- 590

  Fly   262 GGGVGGGGGGVSALSSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVV 326
                     ...|...|..:..|..|:.|.|...:..      .....|.......|.|.:..|.
Human   591 ---------AAPARRRGEEAETQLQAALLKNAWLAEE------NGRLQAKTDWVRKVEAENSEVR 640

  Fly   327 GGGGQGGLSSISALVPNSISGISSSLSSHAIQSMQYGTGQTSVEKL-LSGTSGITGIPPLPVNIH 390
            |..|:       |......||:   ::...:|  |...||...::| ......:..:.|....|.
Human   641 GHLGR-------ACQERDASGL---IAEQLLQ--QAARGQDRQQQLQRDPQKALCDLHPSWKEIQ 693

  Fly   391 TMKAMPTALSQRGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLL 455
            .::..|      |.......:::.||...:.....|.                 .|....:..:.
Human   694 ALQCRP------GHPPEQPWETSQMPESQVKGSRRPK-----------------FHARPEDYAVS 735

  Fly   456 DTGTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPF---T 517
            .....:.....:.|...|.                     .||.|...|.:.....||.|.   |
Human   736 QPNRDIQEKREASLEESPV---------------------ALGESASVPQVSETVPASQPLSKKT 779

  Fly   518 AAALRQASKMKMLDEIDIPLTRYNRSSPCSPIPPNNWGLDEFT----DGL---SVSMMHNRGGLA 575
            ::....:|:..|...:           |.||.      ||..|    |.|   |||:....||.|
Human   780 SSQSNSSSEGSMWATV-----------PSSPT------LDRDTASEVDDLEPDSVSLALEMGGSA 827

  Fly   576 LGALDLDTRNHGLNGASEPQVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLC 640
                                     .|...:..:|:|::.|:|.:..|:       ..||||.|.
Human   828 -------------------------APAAPKLKIFMAQYNYNPFEGPND-------HPEGELPLT 860

  Fly   641 AGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCD 705
            ||||:.::...: :.|:.:.||.||||||||::||:                          |..
Human   861 AGDYIYIFGDMD-EDGFYEGELDDGRRGLVPSNFVE--------------------------QIP 898

  Fly   706 TTSLPS-LPPHNPLLTHTHEDLARLSETHTDLEHDQDDISDNVPAPKHLTLERQLNKSVLIGWSP 769
            .:.:|. ||..:|                 ||...|      :||.:...||..   |:|.|
Human   899 DSYIPGCLPAKSP-----------------DLGPSQ------LPAGQDEALEED---SLLSG--- 934

  Fly   770 PEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDS-TRPHRISVRSVTQNRQTSRDAACTM 833
                      .....||..|...|:...:|....|.:|: |...::.:......:..||....|
Human   935 ----------KAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGT- 988

  Fly   834 IIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPST 898
               :....:.|..:...::|.:||.|:|:.::..|.|||.:::.|......|:..:|..||.|.|
Human   989 ---KGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGT 1050

  Fly   899 QYRVTVRAK---HLRAV--GQHAANVGQTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQEIQLEA 958
            .|||.|..:   .|..|  |..::.|                   .|.||..|.|.||.|:.:|.
Human  1051 HYRVRVEVRLPWDLLQVYWGTMSSTV-------------------TFDTLLAGPPYPPLEVLVER 1096

  Fly   959 GPQDGTILVTWQPV---NRPTSTG-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGV-FNPRA 1018
            ....|.::|:|.||   :..:|.| .||||||||||.||.::...|....:::..:|.| ...:.
Human  1097 HASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQK 1161

  Fly  1019 VTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQMGMG-----PQ-----LPQGPHGMTVQQQM 1073
            |::||.|...:|.||.|..||...  .:..|.|......     |.     .|..|..:::....
Human  1162 VSVRTMSLCGESLDSVPAQIPEDF--FMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPS 1224

  Fly  1074 G-GMPGQPGQQGQHMMGGQQDHGQYDPNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGG----- 1132
            . ..|..||..|:......:...:..|    ::|......|..|..|.:|:|.....|..
Human  1225 AKASPHNPGSCGEPQAKFLEAFFEEPP----RRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGC 1285

  Fly  1133 ----LFSKPTQNQVNQNGYQPGQPGAQRGMVPIPGRPQGPQQQQQQPYGPQGPMGGPRFRGPVPG 1193
                ||.|..||      ::|.....|      ||..:...|.          ||  ..:.|.||
Human  1286 RKDLLFQKSPQN------HRPPSVSDQ------PGEKENCYQH----------MG--TSKSPAPG 1326

  Fly  1194 QLNMQGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMPGQMAGQMAGQMPGQMPGQMPGQM 1258
            .::::.:....:...|.:..::..:..:...|      |..|.|:....      |........:
Human  1327 FIHLRTECGPRKEPCQEKAALERVLRQKQDAQ------GFTPPQLGASQ------QYASDFHNVL 1379

  Fly  1259 SGQMPGQMMGPRGPLNQQQQQQQQ--MQQGQMMPGQQAGQQQAQP-----------------GQP 1304
            ..:.....:..||...::::::.:  .:|||.: |.:.|.|..:|                 |.|
Human  1380 KEEQEALCLDLRGTERREERREPEPHSRQGQAL-GVKRGCQLHEPSSALCPAPSAKVIKMPRGGP 1443

  Fly  1305 GQPGQMPGAQKKPRYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGR 1369
            .|.|  .||....|.|||:.||:|..||.|....:|||.||:...::|:|.:|...||..|...:
Human  1444 QQLG--TGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQ 1506

  Fly  1370 RGYVPHNMVSEVEDTTASMTAGGQMP--GQMP--GQMGQGQGVGV-GGTAQVMPGQGAPQQSMRN 1429
            .|.:|..:|:|:|..|.......:.|  |.:|  ..:...||:.: .|::.|:.|         |
Human  1507 VGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQG---------N 1562

  Fly  1430 VSRDRWGDIYANMPV---KRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYMG 1491
            ..|         :|:   |.|||..||||.:.......:. .|..:.|::::|||.||:.|||.|
Human  1563 SKR---------LPLWTPKIMIAALDYDPGDGQMGGQGKG-RLALRAGDVVMVYGPMDDQGFYYG 1617

  Fly  1492 ELDGVRGLVPSNFL 1505
            ||.|.|||||::.|
Human  1618 ELGGHRGLVPAHLL 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	27/67 (40%)
		FN3	748..822	CDD:238020	15/74 (20%)
		FN3	844..907	CDD:238020	21/62 (34%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	23/60 (38%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	27/60 (45%)
RIMBP3B	NP_001122107.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		GBP_C	<75..139	CDD:303769
		coiled coil	106..117	CDD:293879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..364		14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..811		24/174 (14%)
		SH3_RIM-BP_1	836..895	CDD:212947	26/66 (39%)
		fn3	995..1056	CDD:278470	20/60 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1273		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1292..1325		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1392..1413		4/21 (19%)
		SH3	1456..1517	CDD:302595	23/60 (38%)
		SH3_RIM-BP	1573..1633	CDD:212785	27/60 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14234
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940