Protein Alignment Rbp and Rimbp3

DIOPT Version :9

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_221302.2
• Gene: Rimbp3 / 303785
• RGDID: 1563657
• Length: 1612
• Species: Rattus norvegicus
• Alignment Length: 1672
• Identity: 339/1672 - (20%)
• Similarity: 574/1672 - (34%)
• Gaps: 509/1672 - (30%)

  Fly     2 HLCEFPSA-----NVEEENRRPEKAAAA--ASKKQKHKQQKSRPRGSHSMPYESMHHHQSAAAAV 59
            |.|...:.     ..|.|.|.|...|:.  .|..|...|..|:.|..:.:..||   .::.....
  Rat   282 HSCSLDNTLNCPETSESEVRAPSTTASIPDTSSPQPPPQLPSKHRKPNDLQKES---SENKPCED 343

  Fly    60 AAGTTP-----------NGMLDALSLQLR--------DAEMRRTEIERAHQETLAQIRNLSGSAR 105
            :..::|           :.:.:||.:.:|        :.::|||...   :|...:::.|.....
  Rat   344 STSSSPGLDYHELVRQNSELAEALQVLVRRCCDLREENLQLRRTGFS---EEAGEKVKWLKVKHA 405

  Fly   106 PDAEAVENLQSRARELEKK-----------VALENV------RCEELQ--IELTSALKAK----Q 147
            ...:..:.|:.|||:|::.           .:||.:      .|:..|  .|...||:||    :
  Rat   406 ELTDLAQRLEDRARKLQETNLRAMSAPMPGESLEGLDLGQVFTCQRAQDLSEQAGALQAKDLQIE 470

  Fly   148 ASRSACSGMGSVSSGGGATIPTSASSSTVTWAPTISHQDQG---------SEIDIIMAKIEQD-N 202
            |.|..|..:       .|.|.....||        ||.::|         |::|.:..:.::: .
  Rat   471 ALRRECHLL-------QARIAADLGSS--------SHPEEGATCAQWCNISDLDRLQRESQREVL 520

  Fly   203 RVLAELEQPRTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKR-----AVLGGSGGGG 262
            |:..:|...::.|.|......||:     .||........||.||...:|     :|
  Rat   521 RLQRQLTLHQSKAGAWADTGSPSA-----PSEIARHQVQALERELGLQRRECEELSV-------- 572

  Fly   263 GGVGGGGGGVSALSSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVG 327
                    ..:|....|......|.:.|.        .|..|...:|...|.|:.:..
  Rat   573 --------QAAAAERRYEETEAQLQAALH--------KGARLSEENARLQALANWMKK------- 614

  Fly   328 GGGQGGLSSISALVPNSISGISSSLSSHAIQSMQYGTGQTSVEKLLSGTSGITGIPPLPVNIHTM 392
                         :.:..|.:|.. .|||.|..:........|:||....
  Rat   615 -------------MADENSNVSRQ-QSHARQRQELEATGLLAEQLLQQEG--------------- 650

  Fly   393 KAMPTALSQRGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDT 457
                .|..:|..:|.|  |:.|...|.::...
  Rat   651 ----YAQDRRQQLQQY--QNKTPSDLRISGKE--------------------------------- 676

  Fly   458 GTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAALR 522
                    :.||...|                            |.|   ..||.:...:.:.:|
  Rat   677 --------MQGLQFQP----------------------------GHP---SESSETTQASESQVR 702

  Fly   523 QASKMKM---LDEIDIPL-TRYNRSSPC-----SPIP--------------PNNWGLDEFTDGLS 564
            .:.::|.   .:|..:|| ||..:...|     :|:.              |::..||.......
  Rat   703 DSRRLKFKTKSEEYILPLPTRDIQPPACLSQQENPVALGEPAAASQVSDRNPSSQSLDSKLQAKK 767

  Fly   565 VSMMHNRGGLALG---------ALDLDTRNH----GLNGASEP-QVDMLDIPGKGRCCVFIARFP 615
            .|...|.......         :||:||.:.    ..:..|.| ::..|:.|...:..:|:||:.
  Rat   768 TSSQSNSSSEVESMWATVPSCLSLDMDTASEVDDLEPDSMSTPLEMRSLEAPIVPKLKIFLARYS 832

  Fly   616 YDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVG 680
            ::|       ...|...:..||.|.||||:.|:...: :.|:.:.||::|:|||||::.|:.:.|
  Rat   833 HNP-------FEGPSERSHDELPLTAGDYVYVFGDVD-EDGFYEGELVNGQRGLVPSNLVEPISG 889

  Fly   681 DDLLEFHQAVLSTLRDAEDGSMQCDTTSLPSLPPHNPLLTHTHEDLARLSETHTDLEHDQDDISD 745
                                               :|:|:|..........|....||
  Rat   890 -----------------------------------SPILSHLFLKSPGAGPTSLPAEH------- 912

  Fly   746 NVPAPKHLTLERQLNK-SVLIGWSPPEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDS- 808
                      .:.|.| |:|:|               .|...|:.:.. :.:.:|....|.:.:
  Rat   913 ----------SKALKKGSLLLG---------------EVQERGLCQAG-RVDSKTDVASESLKTK 951

  Fly   809 TRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVC 873
            |....:.::|..:.:..||    .::..:....|.|..::..::|.:||.|:|...::.:.|||.
  Rat   952 TEACWLGLKSSMEEQSFSR----PLLEAKGALCLAPMELQLQNVTATSATITWASGSNRYPHVVY 1012

  Fly   874 VNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQEEAPGAYA 938
            :::.|......|:..:|..||.|.|:|:|.|..:..|.:.|..              .|...:..
  Rat  1013 LDDEEHILTPSGVNHYTFQGLHPGTRYQVRVGVQLPRDLLQVL--------------WETMSSTV 1063

  Fly   939 DFRTLTKGLPDPPQEIQLE---AGPQDGTILVTWQPV---NRPTSTG-PVTGYAVYADGKKVTDI 996
            .|.|...|.||||.::.:|   |.|  |.::|:|.||   :..:|.| .|||||||.||.|||::
  Rat  1064 TFDTPLAGPPDPPLDVLVEHHAASP--GVLVVSWLPVTIDSAGSSNGVQVTGYAVYVDGFKVTEV 1126

  Fly   997 NSPTGDHALIDIGKLGV-FNPRAVTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQMGMGPQL 1060
            .:.|..:.|:::.:|.: ...:.|::||.|...:|.||.|..||....:..           |.|
  Rat  1127 ANATAGNTLLELSQLQLPLGCQKVSVRTMSLYGESLDSVPAQIPEDCFSCY-----------PFL 1180

  Fly  1061 PQGP------------HGMTVQQQMG--GMPGQPGQQGQHMMGGQQDHGQYDPNQM--------- 1102
            ...|            |....|..:.  ..|..||..|:......:...:..|.:.
  Rat  1181 EAPPFNYTDGDPFPVCHQKLAQASLSAKSSPHVPGSCGEPQAKFLEAFSEEQPRKHLSLSSLSSD 1245

  Fly  1103 -QQQQQQQGQPGQPGHQPDAGSGLLGGLLGGLFSKPTQNQVNQNGYQP----GQPGAQRGMVP-- 1160
             ..:|.|.......|::.|..           |.:..||      ::|    ||.|.:.|..|
  Rat  1246 GANKQVQGPTEAWKGYEKDLS-----------FQRSPQN------HKPPLLFGQSGVEEGHAPHI 1293

  Fly  1161 -IPGRPQGPQQQQQQPYGPQGPMGGPRFRGPVPGQLNMQGQQMQGQMQGQMQGQMQGQMSGQMPG 1224
             |.|.|.                         ||.:::..:...|::
  Rat  1294 CISGSPS-------------------------PGFIHLSSEVGPGKI------------------ 1315

  Fly  1225 QMPGQMPGQMPGQMAGQMAGQMPGQMPGQMPGQMSG------QMPGQMMGPRGPLNQQQQQQQQM 1283
             :..:.||.....:..|.|..:|....|......:.      :.....:..|.....:|:::.|.
  Rat  1316 -LCWEEPGLEKALLQNQYAQMVPHHQQGSSQCHTADFHHIFEEKEALCLDSRCTEKPEQRKKSQN 1379

  Fly  1284 QQGQMMPGQQAGQQQAQPGQ--------------PGQPGQMPGAQKKP-RYFVAMFDYDPSTMSP 1333
            .|.|..||.:...|..:|..              .|...|:......| |.|:|:||:.|...|.
  Rat  1380 GQRQGTPGSKRECQFHEPTSVLCPAPTSKIIKIASGGSDQLETDGNSPVRVFLALFDHSPLARSV 1444

  Fly  1334 NPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEVEDTTASMTAGGQMPGQM 1398
            |.:..:|||.||:|..::|:|.:|..|||.||..|:.|.:|.::|.|||..|........:|.|
  Rat  1445 NSEATEEELSFQKGQLLRVWGSRDHHGFYHGECNGQVGKIPGHLVVEVEVGTQQTDGRWLLPPQ- 1508

  Fly  1399 PGQM-GQGQGVGVGGTAQVMPGQGAPQQSMRNVSRDRWGDIYANMPVKRMIALYDYDPQELSPNV 1462
             |.: .:.|...:.|...   .||:......:.:...|       ..|.|:|..||||::....|
  Rat  1509 -GHLHSEAQREDLEGLTN---SQGSYMLQGNSRTPTLW-------TPKTMVAALDYDPRDGRAGV 1562

  Fly  1463 DAEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAP 1509
            .|:. :|..:.|:::.|||.:|:.|||.||..|.|||||::.|.|.|
  Rat  1563 RAKG-KLVLRAGDVVTVYGPVDDKGFYYGEYGGHRGLVPAHLLDDLP 1608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	23/67 (34%)
		FN3	748..822	CDD:238020	11/75 (15%)
		FN3	844..907	CDD:238020	19/62 (31%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	25/60 (42%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	26/60 (43%)
Rimbp3	XP_221302.2	HDc	583..>685	CDD:304369	26/220 (12%)
		SH3	826..886	CDD:302595	23/67 (34%)
		fn3	982..1043	CDD:278470	18/60 (30%)
		SH3	1430..1491	CDD:302595	25/60 (42%)
		SH3	1547..1605	CDD:302595	25/58 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3157
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14234
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.950