Protein Alignment Rbp and Tspoap1

DIOPT Version :9

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_017453169.1
• Gene: Tspoap1 / 287609
• RGDID: 708563
• Length: 1912
• Species: Rattus norvegicus
• Alignment Length: 1965
• Identity: 457/1965 - (23%)
• Similarity: 710/1965 - (36%)
• Gaps: 672/1965 - (34%)

  Fly     6 FPSANVEEENRRPEK---AAAAASKKQKHKQQKSR-----------PRGSHSMPYESMHHHQSAA 56
            ||  ..||:.||.::   ..|..:|:.:.:.||.:           ||     |..|:...:.|.
  Rat   150 FP--ETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRVVSAPVPR-----PGSSLELCRKAL 207

  Fly    57 AAVAAGTTPNGMLDALSLQLRDAEMRRTEIERAHQETLAQIRNLSGSARPDAEAVENLQSRARE- 120
            |...|.....   .|.:|..:|.::  ..::|..:|..|:: :|.|...|....:.:.....||
  Rat   208 ARQRARDLSE---TATALLAKDKQI--AALQRECRELQARL-SLVGKEGPQWLHMRDFDRLLRES 266

  Fly   121 ------LEKKVALENVRCEELQIELTSALKAKQASRSACSGMGSVSSGG-GATI--PTSASSSTV 176
                  |::::||.|.| |.|:       .|:....:|.|.:|:.:.|. |.|:  ....|...|
  Rat   267 QREVLRLQRQIALRNQR-EPLR-------PARSQGSTAPSSVGAPAPGAPGETVLEDDVESPQVV 323

  Fly   177 TWAPTISHQDQGSEIDIIMAK-----IEQD----NRVLAELE-QPRTSASASMSALPPSSMLSTV 231
            ...|....:.|..|.::...:     :||:    .|...||| |.|.:.:.:...:..:|.||..
  Rat   324 LGEPEKQLRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGK 388

  Fly   232 NSEFRTISKSELEEELNRYKRAVLGGSGGGGGGVGGGGGGVSAL--SSGYSSLPQSLASTLPNGG 294
            .:|     |.::|.|....|..:||.:....          |||  |.|..|..:||...|
  Rat   389 ATE-----KEQVEWENAELKGQLLGVTQERD----------SALRKSQGLQSKLESLEQVL---- 434

  Fly   295 ASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISALVPNSISGISSSLSSHAIQS 359
                       .|....|.....:..                     .:..:.:|.......::.
  Rat   435 -----------KHMREVAQRRQQLEE---------------------EHEQARLSLQEKQEEVRR 467

  Fly   360 MQYGTGQTSVE-----KLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTIQLYNLQSTTMPLLS 419
            :|....:...|     :||..|     :..:...:..::....:.::|.::....||:..:
  Rat   468 LQQAQAEAKREHEGAVQLLEST-----LDSMQARVRELEGQCRSQTERFSLLAQELQAFRL---- 523

  Fly   420 LNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLGSTGLSGLGVGP-------SVGG 477
                                      ||     |.||  .|..:.|.:.||..|       |...
  Rat   524 --------------------------HP-----GPLD--LLTSALGCNALGDHPPPHCCCSSPQP 555

  Fly   478 ITGATSLYGLSGGGGGAGGLGSSYGPPFLDV--------ASSASYP----FTAAALRQASKMKML 530
            ..|:                    ||..||:        ...:|.|    .|....|.|.|.:.|
  Rat   556 CQGS--------------------GPKDLDLPPGSPGRCTPKSSEPALATLTGVPRRTAKKAESL 600

  Fly   531 DEIDIPLTRYNRSSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEPQ 595
            .......:.:|....| |.|                             ::||.:.    ..|.:
  Rat   601 SNSSRSESIHNSPKSC-PTP-----------------------------EVDTASE----VEELE 631

  Fly   596 VDMLDI--------PGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGE 652
            ||.:.:        .|..|..||:||:.|:|.:..||       ..|.||.|.||:|:.::.:.:
  Rat   632 VDSVSLLPAAPEGHSGGARIQVFLARYSYNPFEGPNE-------NPEAELPLTAGEYIYIYGNMD 689

  Fly   653 PQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTL-RDAEDGSMQCDTTSLPSLPPHN 716
             :.|:.:.||:||||||||::||:|:..|||       |||| |:..|.| ......|..|....
  Rat   690 -EDGFFEGELMDGRRGLVPSNFVERVSDDDL-------LSTLPRELADSS-HSSGPELSFLSGGG 745

  Fly   717 PLLTHTHEDLARLSETHTDLEHDQDDISDN-----------VPAPKHLTLERQLNKSVLIGWS-P 769
            ...:...:.....|:...:.|...|::|.:           ||.|:|:|:.:||..||::.|. |
  Rat   746 GGCSSGGQSSGGRSQPRPEEEATGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELP 810

  Fly   770 PEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVD-STRPHRISVRSVTQNRQTSRDAACTM 833
            ||.|.   :..:|::|:|.|:..:......:|::|.:| ...|..:||:::| ::.:|....|.:
  Rat   811 PERVD---LRGFHIFVNGELRQALGPGVPPKAVLENMDLRAGPLHVSVQALT-SKGSSDPLRCCL 871

  Fly   834 IIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPST 898
            .:|.. |.:.||.:|...:|.:||.|:|:|.|||..|.|.:|..|....:|..|..|...|.|.|
  Rat   872 AMGAG-AGVVPSQLRIHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCNLRPGT 935

  Fly   899 QYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQE--EAPGAYADFRTLTKGLPDPPQEIQLEAGPQ 961
            .|:..|.|:.            .:.|...||.|  |...|...|.||..||||.|.::|.|.||.
  Rat   936 LYQARVEAQI------------PSQGPWEPGWERPELRAATLQFTTLPAGLPDAPLDVQAEPGPS 988

  Fly   962 DGTILVTWQPVN---RPTSTG-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGVFNP-RAVTI 1021
            .|.::::|.||.   ..||.| .||||||||||:|:.::.|||....|:::.:|.:... ..||:
  Rat   989 PGIVMISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTV 1053

  Fly  1022 RTKSRDSQSADSAP-----------------ILIPN---TVRNAVARRGP--------------- 1051
            ||.|...:|.||.|                 .|.|.   .||..:|...|
  Rat  1054 RTMSPHGESTDSIPAPVAPALASACQPARMSCLSPRPSPEVRTPLASVSPGLGYTSLPLRHPVPH 1118

  Fly  1052 ----------NQMGMGPQ----LP----------------------------------------- 1061
                      .:|..|||    :|
  Rat  1119 GTQDSPASLSTEMSKGPQEEPPVPCSQEEAGSAVHRTSEEKRAMEPTLGQEGPDPVAPFLAKQAV 1183

  Fly  1062 ------QGPHGMTVQQQM------------GGMPGQ---------PGQQGQHMMGGQQDHGQ-YD 1098
                  .||...:.|:::            |.:..:         ..:.|.|::....||.: .|
  Rat  1184 ECTSGDAGPTPCSTQEELTQKEPSTEVCHRGDLDSELKLRSEKEGMSELGVHLVNSLVDHSRNSD 1248

  Fly  1099 PNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGGLFSKPTQNQVNQNGYQPGQPG---------- 1153
            .:.:|::::::.:..:.|.:|.:....:.|           |.:.:||.:| ||.
  Rat  1249 LSDIQEEEEEEEEEEELGSRPCSFQKQVAG-----------NSIGENGAKP-QPDPSCETDSDEE 1301

  Fly  1154 -------------AQRGMVPIP------------GRPQGPQQQQQQPYGPQGPMGGPRFRGPVPG 1193
                         ..:.:..||            |:| ||....|.|..|:..:.|
  Rat  1302 ILEQILELPLQRLCSKKLFSIPEEEEEEDEEEGLGKP-GPSSSSQDPSQPERALLG--------- 1356

  Fly  1194 QLNMQGQQMQG--------QMQGQMQ---------GQMQGQMSGQMPGQMPGQMPGQMPGQMAGQ 1241
             |:.:..|.||        ::.|..:         |....:..|..|.::|.:...|.|.:...:
  Rat  1357 -LDCESSQPQGPGLCPLSPELSGAREHLEDVLGVVGGNSRRRGGCSPEKLPNRKRPQDPREHCSR 1420

  Fly  1242 MAGQ---------MPGQMPGQMP---GQMSGQMPG-------QMMGPRGP--------------- 1272
            :.|.         :|.:..|.:|   |...||.||       ....||||
  Rat  1421 LLGNGGPQTSARPVPPRDRGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCL 1485

  Fly  1273 ---LNQQQQQQQQMQQGQM-------------------------------------MPGQQAGQQ 1297
               :....:.:|::..|.:                                     :|..:.|:.
  Rat  1486 EISIEYDSEDEQEVGSGGVSISSSCYPTDGEAWGTAAVGRPRGPVKVNSGSNTYLRLPAWEKGEP 1550

  Fly  1298 Q----------AQP-----------GQ-------------------------PGQPGQMPGAQKK 1316
            :          .:|           ||                         |..|.:.|..|..
  Rat  1551 ERRGHSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVLRTGTTELAPPRSPQEAPSHQDL 1615

  Fly  1317 P-RYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSE 1380
            | |.|||:|||||.:||||||..:|||||:||..:||||||||||||.||..||.||:|.|||:|
  Rat  1616 PLRVFVALFDYDPISMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAE 1680

  Fly  1381 VEDTT----ASMTAGGQMPGQMPGQMGQGQGVGVGGTAQVMPG---QGAPQQSMRNVSRDRW--- 1435
            |...|    ..:...|.:|   |..:.||.|.|    ..|.|.   .|.|.:..|  |:..|
  Rat  1681 VAVDTPIGRQQLLQRGFLP---PNVLTQGSGNG----PSVYPSAHTPGPPPKPRR--SKKAWDKE 1736

  Fly  1436 -----------GDIYANMPV------------------KRMIALYDYDPQELSPNVDAEQVELCF 1471
                       ..:....|.                  :.|:|.:||:|:|.|||:|.| .||.|
  Rat  1737 GKASRTQRYLLSTVELEDPAQLCPGPPKLIHSAALKTSRPMVAAFDYNPRENSPNMDVE-AELPF 1800

  Fly  1472 KTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAPDQYNNQMGPGGVAGRGGLSQRGRGQGP 1536
            :.|::|.|:|:||:||||.|||:|.|||||||||.          |||..|  |||.. |..|..
  Rat  1801 RAGDVITVFGNMDDDGFYYGELNGQRGLVPSNFLE----------GPGPEA--GGLDS-GTSQAE 1852

  Fly  1537 G------ARGPPPPP 1545
            .      .:|||.||
  Rat  1853 SQDSRVIIQGPPVPP 1867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	28/67 (42%)
		FN3	748..822	CDD:238020	24/75 (32%)
		FN3	844..907	CDD:238020	24/62 (39%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	43/60 (72%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	37/60 (62%)
Tspoap1	XP_017453169.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341622
Domainoid	1	1.000	190	1.000	Domainoid score	I3177
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3157
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44753
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14234
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2282
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.990