Protein Alignment Rbp and Rimbp2

DIOPT Version :10

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_038945054.1
• Gene: Rimbp2 / 266780
• RGDID: 708533
• Length: 1360
• Species: Rattus norvegicus
• Alignment Length: 1352
• Identity: 365/1352 - (26%)
• Similarity: 522/1352 - (38%)
• Gaps: 438/1352 - (32%)

  Fly   533 IDIPLTRYNRSSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEP-QV 596
            :|:||      :|..|       ..::.:||:.|:.....|        .|.::.:.|...| ..
  Rat    96 LDVPL------APGKP-------FSQYMNGLATSIHKGHEG--------PTGHYSVIGDYIPLSG 139

  Fly   597 DMLDIP-----------------------------------GKGRCCVFIARFPYDPPDVHNEFL 626
            |.|:.|                                   ||...||  ||:.|:|.|..||
  Rat   140 DKLESPCVKPSFLLRSSSPRCRFESEMDDDRSSNKSKHSSSGKVHLCV--ARYSYNPFDGPNE-- 200

  Fly   627 SMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVL 691
                 ..|.||.|.||.||.|:...: :.|:.:.|||||:|||||::||     |.:.:......
  Rat   201 -----NPEAELPLTAGKYLYVYGDMD-EDGFYEGELLDGQRGLVPSNFV-----DFIQDNESRFA 254

  Fly   692 STLRDAEDGSMQCDTTSLPSLPPHNPLLTHTHEDLARLSETH-----------TD-----LEHDQ 740
            .||...:|.:                .|.|:...|.|.|..|           ||     |:.:.
  Rat   255 GTLGSEQDQN----------------FLNHSGISLERDSILHLHSPTQVDSGITDNGGGTLDVNI 303

  Fly   741 DDI-SDNVPAPKHLTLERQLNKSVLIGWSPPE-PVGYNLIDSYHVYVDGVLKVTVKANERTRALI 803
            ||| .|.||.|:.:||.:||.|||::||.||. |.|:..:.||:|.||...::::....||:|||
  Rat   304 DDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMSLALGRRTKALI 368

  Fly   804 EGVDSTR-PHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSN 867
            |.:::.. .:||||:.|| :|..|.:..||:::|:|.. :.||.:|..:||..||.:||||.|||
  Rat   369 EKLNTAACTYRISVQCVT-SRGNSDELQCTLLVGKDVV-VAPSQLRVDNITQISAQLSWLPTNSN 431

  Fly   868 HQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQEE 932
            :.|::.:|..|:..||...|::....|.|:..|:|.|.|:..:...|....           |.|
  Rat   432 YSHIIFLNEEELDIVKAARYKYQFFNLRPNMAYKVKVLAQPHQMPWQLPLE-----------QRE 485

  Fly   933 APGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVNRP--TSTG-----PVTGYAVYADG 990
            ...|..:|.||..|.|.|||::.::||....::.|:|:|   |  |.||     .||||.|||.|
  Rat   486 KKEACVEFSTLPAGPPAPPQDVTVQAGATTASVQVSWKP---PALTPTGLSNGANVTGYGVYAKG 547

  Fly   991 KKVTDINSPTGDHALIDIGKLGVFNPRAVTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQMG 1055
            ::|.::.:||.|.|.:::.:|.....:||::||.|...:|.|||...||   .:.:....|:...
  Rat   548 QRVAEVIAPTADGAAVELVRLRSLEAKAVSVRTLSAQGESMDSALAAIP---PDLLVPPAPHPRT 609

  Fly  1056 MGPQLP---------QGPHGMTVQQQMGGMPGQPGQQGQHMMGGQQDH----GQYDPNQMQQQQQ 1107
            ..|..|         .|||....:......|  ||....||:.....|    |:..|:..:...|
  Rat   610 APPPKPLASDMDTKDLGPHVKVDESWEQSRP--PGPAHGHMLEPPDMHSTGPGRRSPSPSRILPQ 672

  Fly  1108 QQGQP---------GQPGHQPDAGSGLLGGLLGGLF-----SKPTQNQVNQNGYQPGQ------- 1151
            .||.|         .:...|..|.|..|.  ...||     :.|..|...::||...:
  Rat   673 PQGAPVSTTVAKAMAREAAQRVAESNRLE--KRSLFLEQSSAGPYANSDEEDGYASPEVKRRGTS 735

  Fly  1152 -----PGAQRGMVP--IPG------------------------------------RPQGPQQQQ- 1172
                 .|::.|..|  ..|                                    ||.|.....
  Rat   736 VDDFLKGSELGQQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGTSHNAL 800

  Fly  1173 --------------QQPYGPQGP---------------------------MGGPRF-------RG 1189
                          :||..||.|                           ||..|.       ||
  Rat   801 KEYHKARSLEGAFLEQPEFPQQPHRSKRLFSIPEVAEEDAEHGEPLLRQGMGSSRARALLAMERG 865

  Fly  1190 PVP---GQLNMQGQQMQGQMQG----------QMQGQMQGQMSGQMP--GQMPGQMPGQMPGQMA 1239
            |..   |...:||..:..:.:|          :.:|....:.:.:.|  |...|....:......
  Rat   866 PARSCWGHPVLQGSWLPAEHRGPGIYMEDLFLEDRGCRFSRSATRSPDSGLDCGSEEEESRFSFR 930

  Fly  1240 GQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLNQQQQQQQQM--------------------- 1283
            ...|...||  ||..|.:.|   |..::..|..|.:|...::..
  Rat   931 STSAKCSPG--PGHCPCRRS---PRPLLARRRTLTRQSSIEEDFGEQVDPSDVIRSDDTQPSPER 990

  Fly  1284 ---------------------QQGQMMPGQQAGQQQAQP-------------------------- 1301
                                 ::...||..:|.::..||
  Rat   991 PVPRRDGWDEASDHEDFRGVWRKSPAMPDSRAAERLTQPPPRVADGPLILGNSALMGRGDRMEHV 1055

  Fly  1302 --------GQPGQPGQM------------------------PGAQKKP-RYFVAMFDYDPSTMSP 1333
                    |.|.:...|                        |||::.| |.|||:|||||.||||
  Rat  1056 SRRYSHSGGGPQRHRPMAPSIDEYTGRDHLSPDFYDESETDPGAEELPARIFVALFDYDPLTMSP 1120

  Fly  1334 NPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEV----EDTTASMTAGGQM 1394
            |||..:|||||:||..|||:|||||||||.||...|.|.:|.|||||:    |:....:...|.:
  Rat  1121 NPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIHADDEEMMDQLLRQGFL 1185

  Fly  1395 PGQMPGQMGQGQGVGVGGTAQVMPGQGAPQQSMRNVSRDRWGDIYANMPVKRMIALYDYDPQELS 1459
            |...|                           :..:.|.|......::|.:||:|||||||:|.|
  Rat  1186 PLNTP---------------------------VEKIERSRRSGRGHSVPTRRMVALYDYDPRESS 1223

  Fly  1460 PNVDAEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNF-----------LADAPDQYN 1513
            ||||.| .||.|.||:||.|:|::||||||.|||:|.:|||||||           |:|||..|:
  Rat  1224 PNVDVE-AELLFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVHLSDAPPHYS 1287

  Fly  1514 NQMGPGGVAGRGGLSQRGRGQGPGARGPPP-------PPRDNMMPGMGGRGQ 1558
            :.......|.|    ....|.|...|.|.|       .|..:|..|..|||:
  Rat  1288 HDPPMRTKAKR----VPPEGSGTARRAPSPTAHLHSGSPTSSMGSGSPGRGR 1335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	COG4913	<69..>148	CDD:443941
		SH3	609..677	CDD:473055	30/67 (45%)
		FN3	748..822	CDD:238020	32/75 (43%)
		COG3979	844..>1004	CDD:443178	59/166 (36%)
		FN3	844..907	CDD:238020	25/62 (40%)
		Med15	<1050..>1272	CDD:312941	63/362 (17%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	42/60 (70%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	43/71 (61%)
Rimbp2	XP_038945054.1	Smc	<2..>82	CDD:440809
		SH3_RIM-BP_1	185..245	CDD:212947	31/74 (42%)
		FN3	296..>560	CDD:442628	102/279 (37%)
		fn3	407..474	CDD:394996	26/66 (39%)
		PHA03321	<582..>728	CDD:223041	35/152 (23%)
		SH3_RIM-BP_2	1106..1167	CDD:212945	42/60 (70%)
		SH3_RIM-BP_3	1210..1270	CDD:212946	42/60 (70%)