DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp and Rimbp3

DIOPT Version :9

Sequence 1:	NP_001189227.1	Gene:	Rbp / 41880	FlyBaseID:	FBgn0262483	Length:	1844	Species:	Drosophila melanogaster
Sequence 2:	NP_001028510.2	Gene:	Rimbp3 / 239731	MGIID:	2685449	Length:	1606	Species:	Mus musculus

Alignment Length:	1625	Identity:	346/1625 - (21%)
Similarity:	563/1625 - (34%)	Gaps:	461/1625 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSANVEEENRRPEKAAAAASKKQKHKQQKSRPRGSHSMPYESMHHHQSAAAAVAAGTTPNGMLDA 71
            |...:...:|:|......:|:.:..:...|.|.|   :.|:.:....|..|            :|
Mouse   317 PPPQLPSIHRKPNDLQKESSENKPCEASTSSPPG---LDYQELVRQNSELA------------EA 366

  Fly    72 LSLQLR---DAEMRRTEIERA--HQETLAQIRNLSGSARPDAEAVENLQSRARELEKK------- 124
            |.:.:|   |.......:.|.  .:|...:::.|........:..:.|:.|||:|::.
Mouse   367 LQVLVRRCCDLREENLHLRRKGFSEEAGEKVKWLKVKHAELTDLAQRLEDRARKLQETNLRAMSA 431

  Fly   125 ----VALENV------RCEELQ--IELTSALKAK----QASRSACSGMGSVSSGGGATIPTSASS 173
                .:||.:      .|:..|  .|...||:||    :|.|..|..:       .|.|.....|
Mouse   432 PVPGESLEGLDLSQVFTCQRAQDLSEQAGALQAKDLQIEALRRECHLL-------QARIAADLGS 489

  Fly   174 STVTWAPTISHQDQG---------SEIDIIMAKIEQD-NRVLAELEQPRTSASASMSALPPSSML 228
            |        ||.::|         |::|.:..:.::: .|:..:|...::.|.|...|..||:
Mouse   490 S--------SHPEEGATCAQWCNISDLDRLQRESQREVLRLQRQLTLHQSKAGAWADAGRPST-- 544

  Fly   229 STVNSEFRTISKSELEEELNRYKR-----AVLGGSGGGGGGVGGGGGGVSALSSGYSSLPQSLAS 288
               .||........||.||...:|     :|                ..:|....|......|.:
Mouse   545 ---PSEITRHQVQALERELGLQRRECEELSV----------------QAAAAERRYEETEAQLQA 590

  Fly   289 TLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISALVPNSISGISSSLS 353
            .|.        .|..|...:|...|.|:.:..                    :.:..|.:|.. .
Mouse   591 ALH--------KGARLSEENARLQALANWMKK--------------------MADENSNVSRQ-Q 626

  Fly   354 SHAIQSMQYGTGQTSVEKLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTIQLYNLQSTTMPLL 418
            ||..|..:........|:||....                   .|..:|..:|.|.
Mouse   627 SHTRQRQELEATSLLAEQLLQQEG-------------------YAQDRRQQLQHYK--------- 663

  Fly   419 SLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLGSTGLSGLGVGPSVGGITGATS 483
                                            |..|.|..|  ....:.||...|.....|..|:
Mouse   664 --------------------------------NKALSDLRT--SGKEMQGLQFQPGHPSETSETT 694

  Fly   484 LYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTA------AALRQASKMKMLDEIDIPLTRYNR 542
            ....|..       ..|..|.|...:.....|...      |.|.|.....:::|........:|
Mouse   695 QASESQA-------RDSGRPTFKTKSEERVLPLPTRDIQPPACLSQQENPVIVEEPAAGPQVSDR 752

  Fly   543 SSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALG---------ALDLDTRNH----GLNGASEP 594
            :|       .:..||........|...|.......         :||:||.:.    ..:..|.|
Mouse   753 NS-------TSQSLDSKPQAKKTSSQSNSSSEVESMWATVPSCLSLDMDTASEVDDLEPDSMSTP 810

  Fly   595 -QVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYL 658
             ::..|:.|...:..:|:||..|:|       ...|....:|:|.|.||||:.|:...: :.|:.
Mouse   811 LEMRSLEAPIIPKLKLFLARSSYNP-------FEGPSEHCQGKLPLTAGDYVYVFGDMD-EDGFY 867

  Fly   659 DAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCDTTSLPSLPPHNPLLTHTH 723
            :.||::|:|||||::.|:.:.|                                   :|:|.|
Mouse   868 EGELVNGQRGLVPSNLVEPISG-----------------------------------SPILNH-- 895

  Fly   724 EDLARLSETHTDLEHDQDDISDN-VPAPKHLTLERQLNKSVLIGWSPPEPVGYNLIDSYHVYVDG 787
                        |.....||... :||.....|::   .|:|:|               .|...|
Mouse   896 ------------LFLKSPDIGPTALPAGHSKVLKK---GSLLLG---------------EVQERG 930

  Fly   788 VLKVTVKANERTRALIEGVDS-TRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASH 851
            :.:|. :.:.:|....|.:.: |....:.::|..:.:..||    .::..:....|.|..::..:
Mouse   931 LCQVG-RVDSKTDMAAESLKTKTEACWLGLKSSLEEQSFSR----PLLEAKGAFCLAPMELQLQN 990

  Fly   852 ITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHA 916
            :|.:||.|:|...::.:.|||.:::.|......|:..:|..||.|.|.|||.|..:..|.:.|..
Mouse   991 VTATSATITWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTCYRVRVGVQLPRDLLQVL 1055

  Fly   917 ANVGQTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPV---NRPTST 978
                          .|...:...|.|...|.||||.::.:|.....|.::|:|.||   :..:|.
Mouse  1056 --------------WETTSSTLTFDTPLAGPPDPPLDVLVEHHASPGVLVVSWLPVTIDSAGSSN 1106

  Fly   979 G-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGV-FNPRAVTIRTKSRDSQSADSAPILIPNT 1041
            | .|||||||.||.|||::...|..:.|::..:|.| .:.:.|::||.|...:|.||.|..||..
Mouse  1107 GVQVTGYAVYVDGFKVTEVADATAGNTLLEFSQLQVPLSCQKVSVRTMSLYGESLDSVPAQIPED 1171

  Fly  1042 VRNAVARRG--PNQMGMGPQLPQGPHGMTVQQQMGGM-----PGQPGQ-QGQHMMGGQQDHGQYD 1098
            ..:.....|  |.....|...|. .|...||..:|..     ||..|: |.:.:....::|.:..
Mouse  1172 FFSCCPFLGAPPFNYTDGNPFPV-CHQKLVQASLGAKSSPRGPGNCGEPQAKFLEAFPEEHPRKH 1235

  Fly  1099 ------PNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGGLFSKPTQNQVNQNGYQP----GQPG 1153
                  .:.....|.|.......|::.|..           |.|..||      ::|    ||.|
Mouse  1236 LSLSSLSSDGTNSQAQGPTEAWKGYEKDLS-----------FQKSPQN------HKPPLLFGQSG 1283

  Fly  1154 AQRGMVP---IPGRPQGPQQQQQQPYGPQGPMGGPRFRGPVPGQLNMQGQQMQGQMQGQMQGQMQ 1215
            .:.|..|   |.|                         .|.||.:::..:...|:::
Mouse  1284 VEEGHAPHICISG-------------------------SPAPGFVHLSSEIGHGKIR-------- 1315

  Fly  1216 GQMSGQMPGQMPGQMPGQMPGQMAGQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLNQQQQQQ 1280
                       ..:.||.....:..|.|..:|....|....|.:            ..:...:::
Mouse  1316 -----------CWEKPGLEKALLQNQYAPMVPPHQQGSSQCQPA------------DFHHVFEEK 1357

  Fly  1281 QQM---QQGQMMPGQ-----QAGQQQAQPGQ-------------------PGQPGQMPGAQKKP- 1317
            :.:   .||...|.|     |.||:|..||.                   .|.|.|:......|
Mouse  1358 EALCLDSQGTEKPEQRKNKSQNGQRQGTPGSKRECSVLCPAPTNKVIKMTSGSPDQLETDANNPV 1422

  Fly  1318 RYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEVE 1382
            |.|:|:||:.|..:|.|.:..:|||.||:|..::|:|..|..|||.||..|..|.:|.::|.|||
Mouse  1423 RVFLALFDHSPLVISVNSEAAEEELAFQKGQLLRVWGSLDLHGFYHGECNGHLGKIPGHLVVEVE 1487

  Fly  1383 DTTASMTAGGQMPGQMPGQ-MGQGQGVGVGGTAQVMPGQGA--PQQSMRNVSRDRWGDIYANMPV 1444
            ..|........:|.|  |. :.:.|...:.|...   .||:  ||.:.|..:  .|       ..
Mouse  1488 VGTQQTDGRWHLPAQ--GHLLSETQREDLEGLTN---SQGSYMPQGNSRTPT--LW-------TP 1538

  Fly  1445 KRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNFLADAP 1509
            |.|:|..||||::....|.|:. :|..:.|:::.|||.:|:.|||.||..|.|||||::.|.|.|
Mouse  1539 KTMVAALDYDPRDGRAGVQAKG-KLVLRAGDVVTVYGPVDDKGFYYGEYGGHRGLVPAHLLDDLP 1602

Fly 1510 1509
Mouse 1603 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	24/67 (36%)
		FN3	748..822	CDD:238020	13/74 (18%)
		FN3	844..907	CDD:238020	20/62 (32%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	25/60 (42%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	26/60 (43%)
Rimbp3	NP_001028510.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SMC_prok_B	<29..671	CDD:274008	82/493 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..352		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..731		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..781		6/43 (14%)
		SH3	826..886	CDD:418401	24/67 (36%)
		FN3	982..1043	CDD:214495	19/60 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1234..1255		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1364..1392		10/27 (37%)
		SH3	1424..1485	CDD:418401	25/60 (42%)
		SH3	1541..1599	CDD:418401	25/58 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14234
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.900