Protein Alignment Rbp and Rimbp2

DIOPT Version :10

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_006504351.1
• Gene: Rimbp2 / 231760
• MGIID: 2443235
• Length: 1370
• Species: Mus musculus
• Alignment Length: 1355
• Identity: 364/1355 - (26%)
• Similarity: 529/1355 - (39%)
• Gaps: 441/1355 - (32%)

  Fly   533 IDIPLTRYNRSSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEP-QV 596
            :|:||      :|..|.|       ::.:||:.|:.....|        .|.::.:.|...| ..
Mouse   103 LDVPL------APGKPFP-------QYMNGLATSIHKGHEG--------PTGHYSVIGDYIPLSG 146

  Fly   597 DMLDIP-----------------------------------GKGRCCVFIARFPYDPPDVHNEFL 626
            |.|:.|                                   ||...||  ||:.|:|.|..||
Mouse   147 DKLESPCVKPSFLLRSSSPRCRFESEMDNDRNSNNSKQSSSGKVHLCV--ARYSYNPFDGPNE-- 207

  Fly   627 SMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVL 691
                 ..|.||.|.||.||.|:...: :.|:.:.|||||:|||||::||      |.::.:::.|
Mouse   208 -----NPEAELPLTAGKYLYVYGDMD-EDGFYEGELLDGQRGLVPSNFV------DFIQDNESRL 260

  Fly   692 S-TLRDAEDGSMQCDTTSLPSLPPHNPLLTHTHEDLARLSETH-----------TD-----LEHD 739
            : ||...:|.:                .|.|:...|.|.|..|           ||     |:.:
Mouse   261 AGTLGSEQDQN----------------FLNHSGISLERDSILHLHSPTQVDSGITDNGGGTLDVN 309

  Fly   740 QDDI-SDNVPAPKHLTLERQLNKSVLIGWSPPE-PVGYNLIDSYHVYVDGVLKVTVKANERTRAL 802
            .||| .|.||.|:.:||.:||.|||::||.||. |.|:..:.||:|.||...::::....||:||
Mouse   310 IDDIGEDTVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMSLALGRRTKAL 374

  Fly   803 IEGVDSTR-PHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANS 866
            ||.:::.. .:||||:.|| :|..|.:..||:::|:|.. :.||.:|..:||..||.:||||.||
Mouse   375 IEKLNTAACTYRISVQCVT-SRGNSDELQCTLLVGKDVV-VAPSQLRVDNITQISAQLSWLPTNS 437

  Fly   867 NHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRAVGQHAANVGQTGGAGRPGQE 931
            |:.|::.:|..|:..||...|::....|.|:..|:|.|.|:..:...|....           |.
Mouse   438 NYSHIIFLNEEELDIVKAARYKYQFFNLRPNMAYKVKVLAQPHQMPWQLPLE-----------QR 491

  Fly   932 EAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVNRP--TSTG-----PVTGYAVYAD 989
            |...|..:|.||..|.|.|||::.:.||....::.|:|:|   |  |.||     .||||.|||.
Mouse   492 EKKEACVEFSTLPAGPPAPPQDVTVHAGATAASVQVSWKP---PALTPTGLSNGANVTGYGVYAK 553

  Fly   990 GKKVTDINSPTGDHALIDIGKLGVFNPRAVTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQM 1054
            |::|.::.:||.|...:::.:|.....:||::||.|...:|.|||...||   .:.:....|:..
Mouse   554 GQRVAEVIAPTADGTAVELIRLRSLEAKAVSVRTLSVQGESMDSALAAIP---PDLLVPPAPHPR 615

  Fly  1055 GMGPQLPQGPHGMTVQQQMG---------GMPGQPGQQGQHMMGGQQDH----GQYDPNQMQQQQ 1106
            ...|..|......|..|.:|         .....||....||:.....|    |:..|:..:...
Mouse   616 TAPPPKPLASDMDTKDQHLGPHVKVDESWEQSRSPGPAHGHMLEPPDMHSAGPGRRSPSPSRILP 680

  Fly  1107 QQQGQP---------GQPGHQPDAGSGLLGGLLGGLFSKPTQ-----NQVNQNGYQPGQ------ 1151
            |.||.|         .:...|..|.|..|.  ...||.:.:.     |...::||...:
Mouse   681 QPQGAPVSTTVAKAMAREAAQRVAESNRLE--KRSLFLEQSSAGQYTNSDEEDGYASPEVKRRGT 743

  Fly  1152 ------PGAQRGMVP-------------------------------------------------- 1160
                  .|::.|..|
Mouse   744 SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGTSHNA 808

  Fly  1161 ---------IPG----RPQGPQQQQQ------------------QPYGPQGPMGGPRF------- 1187
                     :.|    :|:.|||..:                  ||...|| ||..|.
Mouse   809 LKECHKARSLEGAFLEQPEFPQQPHRSKRLFSIPEVAEEDAELGQPLLRQG-MGSSRARALLAME 872

  Fly  1188 RGPVP---GQLNMQGQQMQGQMQG----------QMQGQMQGQMSGQMP--GQMPGQMPGQMPGQ 1237
            |||..   |...:||..:..:.:|          :.:|....:.:.:.|  |...|....:....
Mouse   873 RGPARSCWGHPVLQGSWLPAEHRGPGIHMEDIFLEDRGCRFSRSATRSPDSGLDCGSEEEESRFS 937

  Fly  1238 MAGQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLNQQQQQQQQM------------------- 1283
            .....|...||  ||..|.:.|   |..::..|..|.:|...::..
Mouse   938 FRSTSAKCSPG--PGHCPCRRS---PRPLLARRRTLTRQSSIEEDFGEQVDPSDVIRSDDTQPSP 997

  Fly  1284 -----------------------QQGQMMPGQQAGQQQAQP-----------GQP---GQPGQM- 1310
                                   ::...||..:|.::..||           |..   |:..:|
Mouse   998 ERPMPRRDGWDEASDHEDFRGVWRKSPAMPDSRAAERLTQPPPRVADGPLILGNSTLMGRADRME 1062

  Fly  1311 --------------------------------------------PGAQKKP-RYFVAMFDYDPST 1330
                                                        |||::.| |.|||:|||||.|
Mouse  1063 HVSRRYSHSGGGSHRHRPAMAPSIDEYTGRDHLSPDFYDESETDPGAEELPARIFVALFDYDPLT 1127

  Fly  1331 MSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEV----EDTTASMTAG 1391
            ||||||..:|||||:||..|||:|||||||||.||...|.|.:|.|||||:    |:....:...
Mouse  1128 MSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIHADDEEMMDQLLRQ 1192

  Fly  1392 GQMPGQMPGQMGQGQGVGVGGTAQVMPGQGAPQQSMRNVSRDRWGDIYANMPVKRMIALYDYDPQ 1456
            |.:|...|                           :..:.|.|......::|.:||:|||||||:
Mouse  1193 GFLPLNTP---------------------------VEKIERSRRSGRGHSVPTRRMVALYDYDPR 1230

  Fly  1457 ELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYMGELDGVRGLVPSNF-----------LADAPD 1510
            |.|||||.| .||.|.||:||.|:|::||||||.|||:|.:|||||||           |:|||.
Mouse  1231 ESSPNVDVE-AELPFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVHLSDAPP 1294

  Fly  1511 QYNNQMGPGGVAGRGGLSQRGRGQGPGARGPPP-------PPRDNMMPGMGGRGQ 1558
            .|::.......|.|    ....|.|...|.|.|       .|..:|..|..|||:
Mouse  1295 HYSHDPPMRSKAKR----VPPEGSGTARRAPSPTAHLHSGSPTSSMGSGSPGRGR 1345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	COG4913	<69..>148	CDD:443941
		SH3	609..677	CDD:473055	30/67 (45%)
		FN3	748..822	CDD:238020	32/75 (43%)
		COG3979	844..>1004	CDD:443178	59/166 (36%)
		FN3	844..907	CDD:238020	25/62 (40%)
		Med15	<1050..>1272	CDD:312941	61/363 (17%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	42/60 (70%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	43/71 (61%)
Rimbp2	XP_006504351.1	Smc	<2..>87	CDD:440809
		SH3_RIM-BP_1	192..252	CDD:212947	31/75 (41%)
		FN3	303..>568	CDD:442628	103/280 (37%)
		fn3	414..481	CDD:394996	26/66 (39%)
		PHA03321	<593..>737	CDD:223041	32/148 (22%)
		SH3_RIM-BP_2	1116..1177	CDD:212945	42/60 (70%)
		SH3_RIM-BP_3	1220..1280	CDD:212946	42/60 (70%)