Protein Alignment Rbp and Tspoap1

DIOPT Version :10

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_006532765.1
• Gene: Tspoap1 / 207777
• MGIID: 2450877
• Length: 1907
• Species: Mus musculus
• Alignment Length: 1944
• Identity: 459/1944 - (23%)
• Similarity: 718/1944 - (36%)
• Gaps: 635/1944 - (32%)

  Fly     6 FPSANVEEENRRPEK---AAAAASKKQKHKQQKSR-----------PRGSHSMPYESMHHHQSAA 56
            ||  ..||:.||.::   ..|..:|:.:.:.||.:           ||     |..|:...:.|.
Mouse   150 FP--ETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRVVSAPVPR-----PGSSLELCRKAL 207

  Fly    57 AAVAAGTTPNGMLDALSLQLRDAEMRRTEIERAHQETLAQIRNLSGSARPDAEAVENLQSRARE- 120
            |...|.....   .|.:|..:|.::  ..::|..:|..|:: :|.|...|....:.:.....||
Mouse   208 ARQRARDLSE---TASALLAKDKQI--AALQRECRELQARL-SLVGKEGPQWLHMRDFDRLLRES 266

  Fly   121 ------LEKKVALENVRCEELQIELTSALKAKQASRSACSGMGSVSSG--GGATIPTSASS-STV 176
                  |::::||.|.| |.|:       .|:....:|.|.:|:.:.|  |.|.:.....| ..|
Mouse   267 QREVLRLQRQIALRNQR-EPLR-------PARSPGPTAPSRVGAPAPGAPGEAVLQDDVESPQVV 323

  Fly   177 TWAPTISHQDQGSEIDIIMAK-----IEQD----NRVLAELE-QPRTSASASMSALPPSSMLSTV 231
            ...|....:.|..|.::...:     :||:    .|...||| |.|.:.:.:...:..:|.||.
Mouse   324 LREPEKQQRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSG- 387

  Fly   232 NSEFRTISKSELEEELNRYKRAVLGGSGGGGGGVGGGGGGVSAL--SSGYSSLPQSLASTLPNGG 294
                |...|.::|.|.:..|..:||.:....          |||  |.|..|..:||...|
Mouse   388 ----RATEKEQVEWENSELKGQLLGVTQERD----------SALLKSQGLQSKLESLEQVL---- 434

  Fly   295 ASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVVGGGGQGGLSSISALVPNSISGISSSLSSHAIQS 359
                       .|....|.....:.                     |.:..:.:|.......::.
Mouse   435 -----------KHMREVAQRRQQLE---------------------VEHEQARLSLQEKQEEVRR 467

  Fly   360 MQYGTGQTSVE-----KLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTIQLYNLQSTTMPLLS 419
            :|....:...|     :||..|     :..:...:..::....:.::|.::....||:..:
Mouse   468 LQQAQAEAKREHEGAVQLLEST-----LDSMQARVRELEGQCRSQTERFSLLAQELQAFRL---- 523

  Fly   420 LNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLGSTGLSGLGVGP------SVGGI 478
                                      ||     |.||  .|..:.|.|.||..|      |:...
Mouse   524 --------------------------HP-----GPLD--LLTSALGCSALGDHPPPHCCCSIPQP 555

  Fly   479 TGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAALRQASKMKMLDEIDIPLTRYNRS 543
            ...:....|....|..|........|.|..       .|....|.|.|.:.|.......:.:|..
Mouse   556 CQGSGPKDLDLPPGSPGRCTPKSSEPALTT-------LTGIPRRTAKKAESLSNSSRSESIHNSP 613

  Fly   544 SPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEPQVDMLDI------- 601
            ..| |.|                             ::||.:.    ..|.:||.:.:
Mouse   614 KSC-PTP-----------------------------EVDTASE----VEELEVDSVSLLPAAPES 644

  Fly   602 -PGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYLDAELLDG 665
             .|..|..||:||:.|:|.:..||       ..|.||.|.||:|:.::.:.: :.|:.:.||:||
Mouse   645 HSGGARIQVFLARYSYNPFEGPNE-------NPEAELPLTAGEYIYIYGNMD-EDGFFEGELMDG 701

  Fly   666 RRGLVPASFVQRLVGDDLLEFHQAVLSTL-RDAEDGSMQCDTTSLPSLPPHNPLLTHTHEDLARL 729
            ||||||::||:|:..|||       |||| |:..|.| ......|..|.......:...:.....
Mouse   702 RRGLVPSNFVERVSDDDL-------LSTLPRELADSS-HSSGPELSFLSGGGGGCSSGGQSSGGR 758

  Fly   730 SETHTDLEHDQDDISDN-----------VPAPKHLTLERQLNKSVLIGWS-PPEPVGYNLIDSYH 782
            |:...:.|...|::|.:           ||.|:|:|:.:||..||::.|. |||.|.   :..:|
Mouse   759 SQPRPEEEAAGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELPPERVD---LRGFH 820

  Fly   783 VYVDGVLKVTVKANERTRALIEGVD-STRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSA 846
            ::|:|.|:..:......:|::|.:| .|.|..:||:::| ::.:|....|.:.:|.. |.:.||.
Mouse   821 IFVNGELRQALGPGVPPKAVLENMDLRTGPLHVSVQALT-SKGSSDPLRCCLAVGAG-AGVVPSQ 883

  Fly   847 VRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAKHLRA 911
            :|...:|.:||.|:|:|.|||..|.:.:|..|....:|..|..|...|.|.|.|:..|.|:.
Mouse   884 LRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEAQI--- 945

  Fly   912 VGQHAANVGQTGGAGRPGQE--EAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVN- 973
                     .:.|...||.|  |...|...|.||..||||.|.::|.|.||..|.::::|.||.
Mouse   946 ---------PSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPGPSPGILMISWLPVTI 1001

  Fly   974 --RPTSTG-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGVFNP-RAVTIRTKSRDSQSADSA 1034
              ..||.| .|||||:||||:|:.::.|||....|:::.:|.:... ..||:||.|...:|:||.
Mouse  1002 DAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTVRTMSPHGESSDSI 1066

  Fly  1035 P-----------------ILIPN---TVRNAVARRGPN-------------------------QM 1054
            |                 .|.|.   .||..:|...|.                         :|
Mouse  1067 PAPVAPALASACQPARMSCLSPRPSPEVRTPLASVSPGLGDTSFPLRHPVPHGTQDFSASLSIEM 1131

  Fly  1055 GMGPQ----LP--------------------------QGPHGMT---VQQQMGGMPGQPG----- 1081
            ..|||    :|                          :||..:.   .:|::....|..|
Mouse  1132 SKGPQEEPPVPCSQEEAGAAVRSISEEKRAIEPTLGQEGPEPVAPSLAKQEVECTSGDAGPVPCS 1196

  Fly  1082 ----------------------------------QQGQHMMGGQQDHGQ-YDPNQMQQQQQQQGQ 1111
                                              :.|.|::....||.: .|.:.:|::::::.:
Mouse  1197 TQGELTQKKPSIEACHGGDLDSGLKLRSEKEDMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEE 1261

  Fly  1112 PGQP-GHQPDAGSGLLGGLLGGLFSKPTQNQVNQNGYQPGQPG---------------------- 1153
            ..:. |.:|.:....:.|           |.:.:||.:| ||.
Mouse  1262 EEEELGSRPCSSQKQVAG-----------NSIRENGAKP-QPDPFCETDSDEEILEQILELPLQR 1314

  Fly  1154 -AQRGMVPIPGRPQ-----------GPQQQQQQPYGPQGPMGGP-----RFRGP--VPGQLNMQG 1199
             ..:.:..||...:           ||.:..|.|..|:..:.||     :.:||  .|....:.|
Mouse  1315 LCSKKLFSIPEEEEEEEEEEGLEKPGPSRTSQDPSQPELALLGPGCDSSQPQGPGLCPLSPELSG 1379

  Fly  1200 -----QQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMPGQMAGQMAGQ---------MPGQM 1250
                 :.:.|.:.|  .|:.:|   |..|.::|.:...|.|.:...::.|.         :|.:.
Mouse  1380 VREHLEDVLGVVGG--NGRRRG---GGSPEKLPNRKRPQDPREHCSRLLGNGGPQASARPVPPRE 1439

  Fly  1251 PGQMP---GQMSGQMPG-------QMMGPRGP------------------LNQQQQQQQQMQQG- 1286
            .|.:|   |...||.||       ....||||                  :....:.:|:...|
Mouse  1440 RGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDSEDEQEAGSGG 1504

  Fly  1287 ---------------------------QMMPGQQA--------------------GQQQAQP--- 1301
                                       ::.||..|                    |:.:..|
Mouse  1505 VSINSSCYPTDGEAWGTAAVGRPRGPPKVNPGPNAYLRLPAWEKGEPERRGRSAIGRTKEPPSRA 1569

  Fly  1302 -------GQ-------------------------PGQPGQMPGAQKKP-RYFVAMFDYDPSTMSP 1333
                   ||                         |..|.:.|..|..| |.|||:|||||.:|||
Mouse  1570 TETGESRGQDNSGRRGPQRRGARVPRSGTTELAPPRSPQEAPPHQDLPVRVFVALFDYDPVSMSP 1634

  Fly  1334 NPDGCDEELPFQEGDTIKVFGDKDADGFYWGELRGRRGYVPHNMVSEVE-DTTA----------- 1386
            |||..:|||||:||..:||||||||||||.||..||.||:|.|||:||. |:.|
Mouse  1635 NPDAGEEELPFKEGQLLKVFGDKDADGFYRGESGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGFL 1699

  Fly  1387 -------------SMTAGGQMPGQMPGQMGQGQGVGVGGTAQVMPGQ----------GAPQ---Q 1425
                         |:.:....||. |.:..:.:.|.:.|..|:.||:          |.|:   .
Mouse  1700 PPNVLTEASGNGPSVYSSAHTPGP-PPKPRRSKKVELEGPTQLCPGEKPSLGKCLGRGPPKLIHS 1763

  Fly  1426 SMRNVSRDRWGDIYANMPVKRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFYM 1490
            :.:..||.             |:|.:||:|:|.|||:|.| .||.|:.|::|.|:|:||:||||.
Mouse  1764 AAQKTSRP-------------MVAAFDYNPRENSPNMDVE-AELPFRAGDVITVFGNMDDDGFYY 1814

  Fly  1491 GELDGVRGLVPSNFLADAPDQYNNQMGPGGVAG--RGGLSQRGRGQGP--GARGPPPPP 1545
            |||:|.|||||||||.          |||..:|  ..|.|| ...|.|  ..:|||.||
Mouse  1815 GELNGQRGLVPSNFLE----------GPGPESGSLESGTSQ-AESQDPRITIQGPPVPP 1862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	COG4913	<69..>148	CDD:443941	19/85 (22%)
		SH3	609..677	CDD:473055	28/67 (42%)
		FN3	748..822	CDD:238020	25/75 (33%)
		COG3979	844..>1004	CDD:443178	62/165 (38%)
		FN3	844..907	CDD:238020	23/62 (37%)
		Med15	<1050..>1272	CDD:312941	59/385 (15%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	43/60 (72%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	37/60 (62%)
Tspoap1	XP_006532765.1	Smc	152..>519	CDD:440809	82/441 (19%)
		SH3_RIM-BP_1	653..713	CDD:212947	28/67 (42%)
		FN3	881..943	CDD:238020	23/61 (38%)
		PHA03247	<1339..1730	CDD:223021	99/396 (25%)
		SH3_RIM-BP_2	1620..1681	CDD:212945	43/60 (72%)
		SH3_RIM-BP_3	1772..1831	CDD:212946	37/69 (54%)