DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbp and RIMBP3C

DIOPT Version :9

Sequence 1:	NP_001189227.1	Gene:	Rbp / 41880	FlyBaseID:	FBgn0262483	Length:	1844	Species:	Drosophila melanogaster
Sequence 2:	NP_001122105.1	Gene:	RIMBP3C / 150221	HGNCID:	33892	Length:	1639	Species:	Homo sapiens

Alignment Length:	1641	Identity:	356/1641 - (21%)
Similarity:	569/1641 - (34%)	Gaps:	454/1641 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSANVEEENRRPEKAAAAASKK--------------QKHKQQKSRPR---GSHSMPYE------- 47
            |.|:..||.......:...|::              ..|: :.|.||   ||.|.|.|
Human   303 PKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHR-KLSNPRGGEGSESQPCEVLTPSPP 366

  Fly    48 SMHHHQ--------SAAAAVAAGTTPNGMLDALSLQLR--------DAEMRRTEIERAHQETLAQ 96
            .:.||:        :.|..|.|.....  |...:.|||        |.:::|.:::||
Human   367 GLGHHELIKLNWLLAKALWVLARRCYT--LQEENKQLRRAGCPYQADEKVKRLKVKRA------- 422

  Fly    97 IRNLSGSARPDAEAVENLQSRARELEKKVALENVR----------CEELQI-ELTSALKAKQASR 150
              .|:|.||       .|..|||||::    .|:|          |..|:: ::.:..:|:..|.
Human   423 --ELTGLAR-------RLADRARELQE----TNLRAVSAPIPGESCAGLELCQVFARQRARDLSE 474

  Fly   151 SACSGMGS-----------------VSSGGGATIPTSASSSTVTWAPTISHQDQGSEIDIIMAKI 198
            .|.:.:..                 |:||..:.:.|........|...       .::|.:.
Human   475 QASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNV-------RDLDRLQ--- 529

  Fly   199 EQDNRVLAELEQPRTSASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAV--LGGSGGG 261
            .:..|.:..|::.......:..|.|.:...|....|.|. ....||.||::.:|..  ||..
Human   530 RESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR-QMLALERELDQRRRECQELGTQ--- 590

  Fly   262 GGGVGGGGGGVSALSSGYSSLPQSLASTLPNGGASTSLSGTSLGSHSAAAAAAAHSVSAGSGGVV 326
                     ...|...|..:..|..|:.|.|...:..      .....|.......|.|.:..|.
Human   591 ---------AAPARRRGEEAETQLQAALLKNAWLAEE------NGRLQAKTDWVRKVEAENSEVR 640

  Fly   327 GGGGQGGLSSISALVPNSISGISSSLSSHAIQSMQYGTGQTSVEKL-LSGTSGITGIPPLPVNIH 390
            |..|:       |......||:   ::...:|  |...||...::| ......:..:.|....|.
Human   641 GHLGR-------ACQERDASGL---IAEQLLQ--QAARGQDRQQQLQRDPQKALCDLHPSWKEIQ 693

  Fly   391 TMKAMPTALSQRGTIQLYNLQSTTMPLLSLNSHNLPPAGSTSYSALGAGGGTSLTHPTMANLGLL 455
            .::..|      |.......:::.||...:.....|.                 .|....:..:.
Human   694 ALQCRP------GHPPEQPWETSQMPESQVKGSRRPK-----------------FHARPEDYAVS 735

  Fly   456 DTGTLLGSTGLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAA 520
            .....:.....:.|...|.                     .||.|...|.:.....||.|.:...
Human   736 QPNRDIQEKREASLEESPV---------------------ALGESASVPQVSETVPASQPLSKKT 779

  Fly   521 LRQASKMKMLDEIDIPLTRYNRSS--------PCSPIPPNNWGLDEFT----DGL---SVSMMHN 570
            ..|:                |.||        |.||.      ||..|    |.|   |||:...
Human   780 SSQS----------------NSSSEGSMWATVPSSPT------LDRDTASEVDDLEPDSVSLALE 822

  Fly   571 RGGLALGALDLDTRNHGLNGASEPQVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEG 635
            .||.|                         .|...:..:|:|::.|:|.:..|:       ..||
Human   823 MGGSA-------------------------APAAPKLKIFMAQYNYNPFEGPND-------HPEG 855

  Fly   636 ELSLCAGDYLLVWTSGEPQGGYLDAELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDG 700
            ||.|.||||:.::...: :.|:.:.||.||||||||::||:
Human   856 ELPLTAGDYIYIFGDMD-EDGFYEGELDDGRRGLVPSNFVE------------------------ 895

  Fly   701 SMQCDTTSLPS-LPPHNPLLTHTHEDLARLSETHTDLEHDQDDISDNVPAPKHLTLERQLNKSVL 764
              |...:.:|. ||..:|                 ||...|      :||.:...||..   |:|
Human   896 --QIPDSYIPGCLPAKSP-----------------DLGPSQ------LPAGQDEALEED---SLL 932

  Fly   765 IGWSPPEPVGYNLIDSYHVYVDGVLKVTVKANERTRALIEGVDS-TRPHRISVRSVTQNRQTSRD 828
            .|             .....||..|...|:...:|....|.:|: |...::.:......:..||.
Human   933 SG-------------KAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRP 984

  Fly   829 AACTMIIGRDTAHLGPSAVRASHITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITG 893
            ...|    :....:.|..:...::|.:||.|:|:.::..|.|||.:::.|......|:..:|..|
Human   985 LLGT----KGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQG 1045

  Fly   894 LAPSTQYRVTVRAK---HLRAV--GQHAANVGQTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQE 953
            |.|.|.|||.|..:   .|..|  |..::.|                   .|.||..|.|.||.:
Human  1046 LCPGTHYRVRVEVRLPWDLLQVYWGTMSSTV-------------------TFDTLLAGPPYPPLD 1091

  Fly   954 IQLEAGPQDGTILVTWQPV---NRPTSTG-PVTGYAVYADGKKVTDINSPTGDHALIDIGKLGV- 1013
            :.:|.....|.::|:|.||   :..:|.| .||||||||||.||.::...|....:::..:|.|
Human  1092 VLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVP 1156

  Fly  1014 FNPRAVTIRTKSRDSQSADSAPILIPNTVRNAVARRGPNQMGMG-----PQ-----LPQGPHGMT 1068
            ...:.|::||.|...:|.||.|..||...  .:..|.|......     |.     .|..|..::
Human  1157 LTWQKVSVRTMSLCGESLDSVPAQIPEDF--FMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLS 1219

  Fly  1069 VQQQMG-GMPGQPGQQGQHMMGGQQDHGQYDPNQMQQQQQQQGQPGQPGHQPDAGSGLLGGLLGG 1132
            :..... ..|..||..|:......:...:..|    ::|......|..|..|.:|:|.....|..
Human  1220 LAPPSAKASPHNPGSCGEPQAKFLEAFFEEPP----RRQSPVSNLGSEGECPSSGAGSQAQELAE 1280

  Fly  1133 ---------LFSKPTQNQVNQNGYQPGQPGAQRGMVPIPGRPQGPQQQQQQPYGPQGPMGGPRFR 1188
                     ||.|..||      ::|.....|      ||..:...|.          ||  ..:
Human  1281 AWEGCRKDLLFQKSPQN------HRPPSVSDQ------PGEKENCYQH----------MG--TSK 1321

  Fly  1189 GPVPGQLNMQGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMPGQMPGQMAGQMAGQMPGQMPGQ 1253
            .|.||.::::.:....:...|.:..::..:..:...|      |..|.|:....      |....
Human  1322 SPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQ------GFTPPQLGASQ------QYASD 1374

  Fly  1254 MPGQMSGQMPGQMMGPRGPLNQQQQQQQQ--MQQGQMMPGQQAGQQQAQPGQP------------ 1304
            ....:..:.....:..||...::::::.:  .:|||.: |.:.|.|..:|...
Human  1375 FHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQAL-GVKRGCQLHEPSSALCPAPSAKVIKM 1438

  Fly  1305 --GQPGQM-PGAQKKPRYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGFYWGEL 1366
              |.|.|: .||....|.|||:.||:|..||.|....:|||.||:...::|:|.:|...||..|.
Human  1439 PRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSEC 1503

  Fly  1367 RGRRGYVPHNMVSEVEDTTASMTAGGQMP--GQMP--GQMGQGQGVGVGGTAQVMPGQGAPQQSM 1427
            ..:.|.:|..:|:|:|..|.......:.|  |.:|  ..:...||:       ::| ||:.....
Human  1504 NRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGL-------IIP-QGSSLVLQ 1560

  Fly  1428 RNVSRDRWGDIYANMPV---KRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDEDGFY 1489
            .|..|         :|:   |.|||..||||.:.......:. .|..:.|::::|||.||:.|||
Human  1561 GNSKR---------LPLWTPKIMIAALDYDPGDGQMGGQGKG-RLALRAGDVVMVYGPMDDQGFY 1615

  Fly  1490 MGELDGVRGLVPSNFL 1505
            .|||.|.|||||::.|
Human  1616 YGELGGHRGLVPAHLL 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	SH3	609..677	CDD:302595	27/67 (40%)
		FN3	748..822	CDD:238020	15/74 (20%)
		FN3	844..907	CDD:238020	21/62 (34%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	23/60 (38%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	27/60 (45%)
RIMBP3C	NP_001122105.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		GBP_C	<75..139	CDD:303769
		coiled coil	106..117	CDD:293879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..364		14/61 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..811		25/179 (14%)
		SH3_RIM-BP_1	836..895	CDD:212947	26/66 (39%)
		fn3	995..1056	CDD:278470	20/60 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1273		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1292..1325		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1392..1413		4/21 (19%)
		SH3	1456..1517	CDD:302595	23/60 (38%)
		SH3_RIM-BP	1573..1633	CDD:212785	27/60 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102427at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14234
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.900