Protein Alignment Rbp and rimbp2a

DIOPT Version :10

• Sequence 1: NP_001189227.1
• Gene: Rbp / 41880
• FlyBaseID: FBgn0262483
• Length: 1844
• Species: Drosophila melanogaster
• Sequence 2: XP_073791235.1
• Gene: rimbp2a / 100535071
• ZFINID: ZDB-GENE-100920-2
• Length: 1484
• Species: Danio rerio
• Alignment Length: 1785
• Identity: 413/1785 - (23%)
• Similarity: 632/1785 - (35%)
• Gaps: 613/1785 - (34%)

  Fly    23 AAASKKQKHKQQKSRP--RGSHSMPYESMHHHQSAAAAVAAGTTPNGMLDALSLQLRDAEMRRTE 85
            |:.::.:|..:|:::|  ..||:.      ||.:..                  :|.:.:.|..:
Zfish    34 ASHARAKKKLKQEAQPLHLASHTA------HHVNRC------------------RLLEDKNRALK 74

  Fly    86 IERAHQETLAQIRNLSGSARPDAEAVENLQSRARELEKKVALENVRCEELQIELTSA-LKAKQAS 149
            :|      ||.:|.|....|.....|...:.|.:.||::|..:.:.|:.|:.||..| |:.|:.:
Zfish    75 LE------LAALRQLKQQHRFLESEVNERRKRCQVLEREVKNKTLACKTLKNELQDALLERKRLN 133

  Fly   150 RSACSGMGSVSSGGGATIPTSASSSTVTWAPTISHQDQGSEIDIIMAKIEQDNRVLAELEQPRTS 214
            |.                             .:||..:.:|.:.:.:..||..:....:.|.|..
Zfish   134 RE-----------------------------LLSHILKATEYEKVKSDYEQLKKAFGCVSQERDL 169

  Fly   215 ASASMSALPPSSMLSTVNSEFRTISKSELEEELNRYKRAVLGGSGGGGGGVGGGGGGVSALSSGY 279
            |..                     .|::|:::|
Zfish   170 ARQ---------------------EKAQLQDKL-------------------------------- 181

  Fly   280 SSLPQSLASTLPNGGASTSLSGTSLGSHSAAAA---AAAHSVSAGSGGVVGGGGQGGLSSISALV 341
                ::|...|.:...:..........|..|.|   :....::.             |..:.|..
Zfish   182 ----ENLEQVLKHMREAADRRQQLEAEHEQALAFLNSRQQEINL-------------LQKVQAEA 229

  Fly   342 PNSISGISSSLSSHAIQSMQYGTGQTSVEKLLSGTSGITGIPPLPVNIHTMKAMPTALSQRGTI- 405
            ......:...|.|| :..||                         |.:|.::....|.|::..|
Zfish   230 EKEREEVVHLLESH-MDKMQ-------------------------VKVHDLEQKCRAQSEQCNIL 268

  Fly   406 ----QLYNLQSTTMPLLSLNSH--NLPPAGSTSYSALGAGGGTSLTHPTMANLGLLDTGTLLGST 464
                :.|:|.|.....|:.:|.  ||    ..||::|......|
Zfish   269 SKELEKYHLGSDAEDTLNTDSQEKNL----CNSYNSLQRQAEKS--------------------- 308

  Fly   465 GLSGLGVGPSVGGITGATSLYGLSGGGGGAGGLGSSYGPPFLDVASSASYPFTAAALRQASKMKM 529
                                                      |..|..|...:...:.|..|...
Zfish   309 ------------------------------------------DERSDGSPLVSELPIVQQHKRDK 331

  Fly   530 LDEIDIPLTRYNRSSPCSPIPPNNWGLDEFTDGLSVSMMHNRGGLALGALDLDTRNHGLNGASEP 594
            .:::.:..|...||...||:.                       .:|..:|.:.|        .|
Zfish   332 PEQLTVKPTVQTRSRSSSPMQ-----------------------ASLSEMDDEVR--------PP 365

  Fly   595 QVDMLDIPGKGRCCVFIARFPYDPPDVHNEFLSMPCREAEGELSLCAGDYLLVWTSGEPQGGYLD 659
            ........|:.|.|.  ||:.|:|.|..||       ..|.||.|.||.||.|:.:.:..|.| :
Zfish   366 SRSKTRYTGQVRLCT--ARYSYNPYDGPNE-------HPEAELPLVAGKYLYVYGNMDDDGFY-E 420

  Fly   660 AELLDGRRGLVPASFVQRLVGDDLLEFHQAVLSTLRDAEDGSMQCDTTSLPSLPPHNPLLTHTHE 724
            .|||||:|||||::||:.:...:.|.....       .|.|.::....||.::....||.:.:.:
Zfish   421 GELLDGQRGLVPSNFVEFVQDKEKLSIEGV-------EEQGRLEQSCLSLTTIDGGGPLDSISSD 478

  Fly   725 DLARLSETHTDLEHDQ--DDISDNVPAPKHLTLERQLNKSVLIGW-SPPEPVGYNLIDSYHVYVD 786
            .|...|.....|:.::  :||   ||.|:.:.|.:||.:||::.| :|..|:|:..|:.|::.|:
Zfish   479 VLGHCSNGTGALDGEELGEDI---VPYPRKINLIKQLARSVIVAWEAPMVPLGWGNINGYNILVE 540

  Fly   787 GVLKVTVKANERTRALIEGVD-STRPHRISVRSVTQNRQTSRDAACTMIIGRDTAHLGPSAVRAS 850
            |.::.:|....||:.|:|.:| :...:|:||:||| :|..|.:..||:::||:.. :.|:.:|..
Zfish   541 GEVRSSVPFGGRTKLLLEKLDLAAFTYRVSVQSVT-DRGLSDELRCTLLVGRNVV-VAPTGLRMD 603

  Fly   851 HITCSSAVISWLPANSNHQHVVCVNNVEVRTVKPGMYRHTITGLAPSTQYRVTVRAK------HL 909
            .|...||.:||||:|||:.|||.::.||...|||..|:.....|..:|.|:|.|.||      |:
Zfish   604 DILRDSAELSWLPSNSNYAHVVYLDGVEHAVVKPCSYKLRFVNLKAATVYKVKVLAKPHQVPWHM 668

  Fly   910 RAVGQHAANVGQTGGAGRPGQEEAPGAYADFRTLTKGLPDPPQEIQLEAGPQDGTILVTWQPVNR 974
            ..                 .|.|...|..:|.|...|.|.||||:|::.|...|.:.|.|:|
Zfish   669 PL-----------------EQREKREAGVEFCTQAAGPPLPPQEVQVQCGHAPGILQVRWKP--- 713

  Fly   975 PT------STGP-VTGYAVYADGKKVTDINSPTGDHALIDIGKLGVFNPRAVTIRTKSRDSQSAD 1032
            |.      |.|. :.||||...|:::.::..|..|:..:::.:|.....|.|.:||.|...:|.|
Zfish   714 PAMSPIGMSNGANIIGYAVCTKGQRIAEVLYPMADYVAVELNRLQCLEAREVIVRTLSAQGESQD 778

  Fly  1033 SAPILIPNTVRNAVARRGPNQMGMGPQLP-QGPHGMTVQQQ-------------MGGMPGQPGQQ 1083
            |...:|||.:...:::..|....|.|.|| |..|.|....|             :..:|..|.|.
Zfish   779 SHVAVIPNHLLVPLSKTLPLPHRMQPPLPTQQSHTMPHHPQILPRHTGPQPPTHLQPLPICPNQP 843

  Fly  1084 GQHMMGGQQDHGQYDPNQMQQQQQQ--------QGQPGQPGHQPDAGSGLLGGLLGGLFSKP-TQ 1139
            ..|:...:..|    |.|......|        |.||..|..||.:             |.| .|
Zfish   844 PAHLHPHRMPH----PTQPSPPHLQPLLAHPIPQPQPSIPMPQPQS-------------SMPMPQ 891

  Fly  1140 NQVNQNGYQPGQPGAQ-RGMVPIPGRPQGPQQQQQQPYGPQGPMGGPR---------FRGPVPGQ 1194
            :|......||.||... :...|||.....|.....||:.||.|:..|:         .:.|.||.
Zfish   892 SQPPMPMPQPQQPMTMPQPQPPIPMLQPQPAIPMPQPHIPQLPLPQPQRPLSARELETKEPGPGM 956

  Fly  1195 LNMQGQQMQGQMQGQMQGQMQGQMSGQMPGQMPGQMP----------------------GQMPGQ 1237
            |:..|            |..|....|..|..:|..||                      .|..|.
Zfish   957 LHHGG------------GPPQPWEPGCSPSGIPTGMPHGHTLEAPACPNRRSPSPQRILPQPRGT 1009

  Fly  1238 MAGQMAGQMPGQMPGQMPGQMSGQMPGQMMGPRGPLNQQQQQQQQMQQ-------GQMMPGQQAG 1295
            :......:...:...|.....||:|..:..|.....:.:::.::..|.       ...:.|.:.|
Zfish  1010 LIPDTVAKAIAREAAQRVAAESGRMERRSQGFHSQNSDEEEDEESYQARRRGASVDDFLRGSELG 1074

  Fly  1296 QQ----------------------------------QAQPGQ----------------PGQ---- 1306
            :|                                  |.:.|:                .||
Zfish  1075 RQPHYSHSEEYHTESSRGSDLSDIMEEDEEELYSEMQHEEGRRRNSHNALKTGGSTLSSGQLDRD 1139

  Fly  1307 -----PGQMPGAQKKP------------------------------------------------- 1317
                 |.:.|..|::|
Zfish  1140 SYRKAPHRGPQPQRRPLTVPSIEITTESNSEGNLSPVKEDVYYGSVARHRTWSSRRHGGRRPPYD 1204

  Fly  1318 ---------------------RYFVAMFDYDPSTMSPNPDGCDEELPFQEGDTIKVFGDKDADGF 1361
                                 |.|||:|||||.:||||||..||||||:||..|||:||||.|||
Zfish  1205 GYRDRSRRSPPYYDESEQEDFRIFVALFDYDPLSMSPNPDAADEELPFKEGQIIKVYGDKDNDGF 1269

  Fly  1362 YWGELRGRRGYVPHNMVSEV----EDTTASMTAGGQMPGQMPGQMGQGQGVGVGGTAQVMPGQGA 1422
            |.||:|||.|.:|.|||||:    ::|...:...|.:|...|
Zfish  1270 YRGEIRGRSGLIPCNMVSEIRAEDDETMEQLMKQGFLPLNTP----------------------- 1311

  Fly  1423 PQQSMRNVSRDRWGDIYANMPV--KRMIALYDYDPQELSPNVDAEQVELCFKTGEIILVYGDMDE 1485
                :..:.::|.|    ..||  :||:|||||||:|.|||||.| .||.|..|:|:.|:||:||
Zfish  1312 ----VDRIEQNRRG----RHPVATRRMVALYDYDPRESSPNVDVE-AELTFCAGDIVAVFGDIDE 1367

  Fly  1486 DGFYMGELDGVRGLVPSNFLADAPDQYNNQMGPGGVAGRGGLSQRGRGQGPGARGPPPPPRDNM- 1549
            ||||.|||:|.|||||||||.:.||.....           |:......|.....|.|..|...
Zfish  1368 DGFYYGELNGHRGLVPSNFLEEVPDDVEVY-----------LTDTPSHHGQDESNPAPAARPEAK 1421

  Fly  1550 ---------MPGMGGRGQPGKNARPASPTL 1570
                     .|.:|         ||||||:
Zfish  1422 RVPVESTVPAPALG---------RPASPTV 1442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbp	NP_001189227.1	COG4913	<69..>148	CDD:443941	20/79 (25%)
		SH3	609..677	CDD:473055	30/67 (45%)
		FN3	748..822	CDD:238020	27/75 (36%)
		COG3979	844..>1004	CDD:443178	56/172 (33%)
		FN3	844..907	CDD:238020	26/62 (42%)
		Med15	<1050..>1272	CDD:312941	60/276 (22%)
		SH3_RIM-BP_2	1319..1380	CDD:212945	43/60 (72%)
		SH3_RIM-BP_3	1446..1507	CDD:212946	43/60 (72%)
rimbp2a	XP_073791235.1	None