Protein Alignment h-cup and FGFR1OP2

DIOPT Version :10

• Sequence 1: NP_650462.1
• Gene: h-cup / 41879
• FlyBaseID: FBgn0038334
• Length: 256
• Species: Drosophila melanogaster
• Sequence 2: NP_056448.1
• Gene: FGFR1OP2 / 26127
• HGNCID: 23098
• Length: 253
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 54/234 - (23%)
• Similarity: 97/234 - (41%)
• Gaps: 52/234 - (22%)

  Fly    14 IKEYKDFAKCLDELEFKTDELLIDAKMVDQELANCHKFREDQ----LLKHLTEKNDDDEQMQLLR 74
            ::::.|.|:.|.|.....::.:...|...:|:...::....:    |:..:.::|....::|  :
Human    19 LRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQ--Q 81

  Fly    75 ENIELKATGVEFQHGIELIMEKYRE-----------------------HSEGDML---------I 107
            ||.||:.:..|.|..:||||.||||                       ||:.||:         :
Human    82 ENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNKSEGFFL 146

  Fly   108 DT---------YQLREHYLAGLSKVVEEQDARIERMVDVMKLTVDFEDRSSAENQQIICQLTDEN 163
            |.         :.|...:|......::....:|..|..||:..::.:::...:.|:.|.||..||
Human   147 DASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQEN 211

  Fly   164 EQLRRQLQISTTDELF---RQGALSSSESSTQIGPNDSL 199
            :.||..|||  |.|.|   |:...|.|.|.:.:..|..|
Human   212 KGLREILQI--TRESFLNLRKDDASESTSLSALVTNSDL 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
h-cup	NP_650462.1	SIKE	12..173	CDD:461735	44/203 (22%)
FGFR1OP2	NP_056448.1	SIKE	2..221	CDD:461735	45/205 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..253		5/18 (28%)