DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14868 and CCDC149

DIOPT Version :9

Sequence 1:	NP_650458.1	Gene:	CG14868 / 41875	FlyBaseID:	FBgn0038330	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_011512208.1	Gene:	CCDC149 / 91050	HGNCID:	25405	Length:	540	Species:	Homo sapiens

Alignment Length:	498	Identity:	153/498 - (30%)
Similarity:	245/498 - (49%)	Gaps:	100/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ATYNVETSAVHRKLQSKVEALRILRQELEQFRVERDQYKLVAETLQLRYSALKSNSELLAVGGCG 81
            ||::.|.....|||:||.|||.||.:||:..:.|||||||:|..|:.|:.:||.....|..|...
Human    16 ATWDSEYLVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPS 80

  Fly    82 ALSE---NSSLAALLHETREQNLKLSTEVEALRQRLNELHGDMELLRETEASNKSRVQAMASEN- 142
            ...|   .::||.||.:::::|..|..|::.|:|||.|:.||.:|||.|.|..:...:|:...:
Human    81 LPPEKRKQANLAQLLRDSQDRNKHLGEEIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHF 145

  Fly   143 AARNKEELQWRRERANFICHLEGLKKRNAQLAFDLKAVIDEKEELITERDAYKCKAHRLNHELFV 207
            ||..:|:|..:.|||         |::...|..||:|.:||.:::..||.:|:.|..|||.||..
Human   146 AAHEREDLVQQLERA---------KEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNH 201

  Fly   208 ALRAKKTHPRLLDIDGVLLENKYLHERVKIQDSELELTKQSINKYKTMLDAKRKKGIVKLGGGST 272
            .|...:.  |::|:|.:.:||:||.||:|....|:.|.|.:|.|||..|:  |:|.....|..|:
Human   202 ILSGHEN--RIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALE--RRKNSKGQGKSSS 262

  Fly   273 NEDT-ILSPRQVKTIL--ESGIELPQKTESLSDLKSLCLALLDNLNDKNLALTHQKKTNKILAGK 334
            :..| :||.:||:.:|  :.|..||...:|:||||||..|||:.:::||:.:.||::|||||..:
Human   263 SALTGVLSAKQVQDLLSEDHGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNR 327

  Fly   335 MTELEQRWQQL-LSG-------------------------------------------------- 348
            :.|||::.:.| :||
Human   328 VAELEKKLRTLEVSGLWSLPGLSYNVSVGFGRGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENK 392

  Fly   349 ---NDDNAEEQEEDVEYGYAPSQLLLNGYCAAMVDDADISSTPSIEPDNEGVAITADHEDSKK-- 408
               .|..|::||||..             |||    |:..:.|.   |....|:.:....|:.
Human   393 ADPKDGEAQKQEEDES-------------CAA----AEALTAPE---DAGRPAVNSPANQSRGNQ 437

  Fly   409 ----HKSVEALHSDDGMSSLSTESVDSSVYGADVQPDDFQKSS 447
                |.|:..|.|::.::||..|.:..:...|..:.::.::.|
Human   438 CKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRES 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14868	NP_650458.1	DUF2353	27..345	CDD:286828	124/324 (38%)
CCDC149	XP_011512208.1	DUF2353	26..338	CDD:286828	124/324 (38%)
CCDC149	XP_011512208.1	MIT_CorA-like	<91..>211	CDD:294313	45/130 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153869
Domainoid	1	1.000	159	1.000	Domainoid score	I4098
eggNOG	1	0.900	-	-		E1_KOG4687
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4272
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D308165at33208
OrthoFinder	1	1.000	-	-		FOG0006076
OrthoInspector	1	1.000	-	-		oto89669
orthoMCL	1	0.900	-	-		OOG6_108128
Panther	1	1.100	-	-	LDO	PTHR21682
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4132
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.790