DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14868 and ccdc149b

DIOPT Version :9

Sequence 1:	NP_650458.1	Gene:	CG14868 / 41875	FlyBaseID:	FBgn0038330	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_009291064.1	Gene:	ccdc149b / 436983	ZFINID:	ZDB-GENE-040718-465	Length:	573	Species:	Danio rerio

Alignment Length:	557	Identity:	166/557 - (29%)
Similarity:	265/557 - (47%)	Gaps:	117/557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RKLQSKVEALRILRQELEQFRVERDQYKLVAETLQLRYSALKSNSELLAVGGCGALSENS---SL 89
            |||:||.|||.||.:||:..:.||||:||:|..|:.|:..||.....|..|......|..   :|
Zfish    23 RKLESKKEALLILSKELDTCQQERDQFKLMANQLRERHQGLKKKYRELIDGDPSLPPEKRNQVNL 87

  Fly    90 AALLHETREQNLKLSTEVEALRQRLNELHGDMELLRETEASNKSRVQAMASENAARNKEELQWR- 153
            |.||.::||.|.:||.|::.|:|||.|:|||.:|||.|.|  |.|:          ..||:..|
Zfish    88 AQLLRDSREHNKQLSEELKELKQRLAEVHGDNKLLRMTIA--KQRL----------GDEEVGTRH 140

  Fly   154 ---RERANFICHLEGLKKRNAQLAFDLKAVIDEKEELITERDAYKCKAHRLNHELFVALRAKKTH 215
               .||.:.:..||..:::...|...|||..||.:::..||:.|:.||||||.|:...|.:.:.
Zfish   141 FPAHEREDLVQQLERAREQTEALEQSLKAATDELQDVRAERNVYQEKAHRLNLEINHILGSHEN- 204

  Fly   216 PRLLDIDGVLLENKYLHERVKIQDSELELTKQSINKYKTMLDAKRKKGIVKLGGGSTNEDT---I 277
             |:||||.:.:||:|||||:.....|:.|.|.::.|||:.|::|:...:.    |.:|...   :
Zfish   205 -RILDIDALCMENRYLHERLMQLQEEVSLLKSNVMKYKSALESKKNCKVY----GKSNSSALTGV 264

  Fly   278 LSPRQVKTIL---ESGIELPQKTESLSDLKSLCLALLDNLNDKNLALTHQKKTNKILAGKMTELE 339
            ||.:||:.:|   |:|..||..::|:||||||..|||:.:::||:.:.||::|||||..::.|||
Zfish   265 LSAKQVQELLLSEENGCSLPVTSQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELE 329

  Fly   340 QRWQQL-LSG------------------------NDD-------------------------NAE 354
            ::.:.| :||                        :|.                         ..|
Zfish   330 RKLKTLEVSGLWSLPGITYNVSLGLGRRKAVIVLSDSQHVQSTTEQSVHLTPEAMVADEEIVTGE 394

  Fly   355 EQEEDVEYGYAPSQ-------LLLNGYCAAMVDDADISSTP-------SIEP------------D 393
            |..||.......||       :.||...........:|:||       :|:|            |
Zfish   395 EVTEDTGLSADFSQDECQAGAVELNQNSDYFTHTYSVSATPQVSTPAENIQPVESMQSKTLALCD 459

  Fly   394 NEGVAITAD----HEDSKKHKSVEALHSDDGMSSLSTESVDSSVYGADVQP----DDFQKSSSAT 450
            :|..|.||:    |::..:....:::.::..:.:|..::|::..:..|.:.    :|.|..:|.|
Zfish   460 SERSACTAERSEQHDEDLQSGGHQSMSTEASLKALEEQAVENDNFSGDCESQGALEDSQPVTSET 524

  Fly   451 TDSGNC-GLSSRCNGTPRISSAVARE-RMEDLKDLPP 485
            :.|.:| ..|..|....:...::..| ....|...||
Zfish   525 SGSFDCISGSESCTAEQQTERSIEEETEHASLNTSPP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14868	NP_650458.1	DUF2353	27..345	CDD:286828	128/329 (39%)
ccdc149b	XP_009291064.1	DUF2353	22..335	CDD:286828	128/329 (39%)
ccdc149b	XP_009291064.1	GrpE	147..>194	CDD:295646	17/46 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589059
Domainoid	1	1.000	166	1.000	Domainoid score	I3831
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D308165at33208
OrthoFinder	1	1.000	-	-		FOG0006076
OrthoInspector	1	1.000	-	-		otm24790
orthoMCL	1	0.900	-	-		OOG6_108128
Panther	1	1.100	-	-	LDO	PTHR21682
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860