DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34404 and USHBP1

DIOPT Version :9

Sequence 1:	NP_650457.2	Gene:	CG34404 / 41873	FlyBaseID:	FBgn0085433	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001308346.1	Gene:	USHBP1 / 83878	HGNCID:	24058	Length:	703	Species:	Homo sapiens

Alignment Length:	745	Identity:	169/745 - (22%)
Similarity:	286/745 - (38%)	Gaps:	199/745 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GRHL-VGSSD--LDSPEHTQRDTTESDNNISS---CSTLDIVNKVEQLSVQQLENRVRDLTQRLQ 117
            |||. .|..|  .:|.|..:..:..|..:.:.   .|.|:.:..:|::|.|.|.:|    |.:..
Human    13 GRHAPPGELDPVAESSEEVEAASGSSKPSFAPPPVSSGLEQLGPMEEVSGQGLGSR----TDKKM 73

  Fly   118 Q--AERQLTESNTEREICHKRLEVVSQAHECRITEMHCVIAELSKKLRSKQDHVIMEEQEPDGSE 180
            .  :.|:|..:   .|:.||......||.|          |.|..|           |..|.|:
Human    74 DGGSGRELASA---PEVPHKPAVEAHQAPE----------AALQYK-----------ETVPPGN- 113

  Fly   181 LSFQEGSVYNSELNLTNPDA-ECQTEPLEDFEGACSTTSVGNVAHKPPELSHKGQVE-------- 236
                 |:          ||. :.....|...|.|.:..     .|:||  ||.|.:|
Human   114 -----GA----------PDVFQTLQHTLSSLEAAAAAW-----RHQPP--SHSGPMEFEGTSEGG 156

  Fly   237 -----------ALQEEVLHLRARIALLQSEISTKDAAVVEEQTKV-AFDCE-----SEVNECGQR 284
                       :.|.|...|..|.|.|:..:|:::..:|..|..: |...|     .||.|....
Human   157 AGSLGKQEGAGSCQREAARLAERNAWLRLALSSREDELVRTQASLEAIRAEKETLQKEVQELQDS 221

  Fly   285 LNDLNVCTSLTSPQKRIPAVPKMAERVKLRCASKHESGEDP--SQDT-SLSNEQI-NLVEH---- 341
            |..|..|..|:..|.....          ..:|..|:..:|  :||: ||::..: .|..|
Human   222 LLRLEPCPHLSHNQAGGSG----------SGSSSSEADREPWETQDSFSLAHPLLRRLRSHSSTQ 276

  Fly   342 LVSELKEQNLYMENFMEPLHLSK-DLERLQRRVEQLEMRNTMLALTLDECKEHTEHLYLLCGKYE 405
            ::..|..|.|..|     :|:.: .:|:|:..:|:|:..|.:|:..|...|...|.|.:..|:.|
Human   277 ILGSLPNQPLSPE-----MHIMEAQMEQLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQRE 336

  Fly   406 SNAVALQLALNCSDRAIEAYDVMLALLESKLALLGEKSVAAEESRRS----VEAVARHLLARLDS 466
            :.|.||.|||..|:...|||.|:|||.|:       .|.|.:|:..|    .|..|..|||:.::
Human   337 AEATALHLALQYSEHCEEAYRVLLALREA-------DSGAGDEAPMSDLQAAEKEAWRLLAQEEA 394

  Fly   467 EKNVCENSLGPWQHNINLGPEDAPK---TGRPWCADDDNRLRYHVSKLKGRRSNVQ------HTI 522
            ..:.     |..|:     |:.:|:   ..:|...:...:||.:|.:|:.|||.::      .|:
Human   395 AMDA-----GAQQN-----PQPSPEGSSVDKPTPQEVAFQLRSYVQRLQERRSLMKILSEPGPTL 449

  Fly   523 VSLES-PFSDIYERKRLALEKEHELRSADKKSPIDLETAVIMQEILELRDS------NLQLKTKM 580
            ..:.: |.::...:..|..:....|..        ||...|.|:::..|::      .|||..:.
Human   450 APMPTVPRAEAMVQAILGTQAGPALPR--------LEKTQIQQDLVAAREALADLMLRLQLVRRE 506

  Fly   581 EEAEQERQNANERVGILHE-ALKQLQ----------ANNRVSYSEAEHAALTE------------ 622
            :...:.|:.|...:|..|. .|:||:          ||:...:|....::..|
Human   507 KRGLELREAALRALGPAHVLLLEQLRWERAELQAGGANSSGGHSSGGGSSGDEEEWYQGLPAVPG 571

  Fly   623 --------------------QQLVEALTRETELKGRIQTLLANV-TASQKAFDEKYEQLHQNVRE 666
                                |:|..:|||..:|:.::|:|...: ..:||....:.:....| |:
Human   572 GTSGIDGGQVGRAWDPEKLAQELAASLTRTLDLQEQLQSLRRELEQVAQKGRARRSQSAELN-RD 635

  Fly   667 LQKSNHNLGQMLDHTKRKYQLRVRKLEQKI 696
            |.|::..|........||.:.:.|||||::
Human   636 LCKAHSALVLAFRGAHRKQEEQRRKLEQQM 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34404	NP_650457.2	SCP-1	<99..599	CDD:114219	128/556 (23%)
		MCC-bdg_PDZ	368..432	CDD:287477	24/63 (38%)
		WXG100	609..696	CDD:295131	24/119 (20%)
USHBP1	NP_001308346.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		29/127 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..172		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..256		6/37 (16%)
		MCC-bdg_PDZ	299..363	CDD:287477	24/63 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..583		4/42 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.990