DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34404 and Mcc

DIOPT Version :9

Sequence 1:	NP_650457.2	Gene:	CG34404 / 41873	FlyBaseID:	FBgn0085433	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001078842.1	Gene:	Mcc / 328949	MGIID:	96930	Length:	1003	Species:	Mus musculus

Alignment Length:	896	Identity:	214/896 - (23%)
Similarity:	370/896 - (41%)	Gaps:	274/896 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GSSDLDSPE-HTQRD---------------------TTESDNNISSC--STLDIVNKVEQLSVQQ 104
            |:.||.||: .:||.                     .|.:.|..:|.  |.|::.:.:...::..
Mouse   138 GARDLQSPDLQSQRPLQKLLEYGGSSLPQQAVLHKLLTHAPNFGTSTGGSYLELASTLHLAALAS 202

  Fly   105 LENRVRDLTQRLQQAERQLTESNTEREICHKRL------------------EVVSQAHECRITEM 151
            |:..:.:|.:||||.||       ||::..|:|                  |..:..:|.||||:
Mouse   203 LKGDIVELNKRLQQTER-------ERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITEL 260

  Fly   152 HCVIAELSKKLRSKQDHVIMEEQE-----------------------PDGSELSFQEG------- 186
            |.:||||:||:...|...|.||.|                       .|.:.:|..|.
Mouse   261 HSIIAELNKKIDRLQGTTIREEDEYSELRSELSQSQQEVNEDSRSVDQDQTSVSIPENQSTMVTA 325

  Fly   187 -----SVYNSEL-------------------------------NLTNPDAECQ--TEPLEDFEGA 213
                 |..||||                               .||.....|.  .:.:|:.||.
Mouse   326 DMDNCSDLNSELQRVLTGLESVVCGRKKSSCSLSVADVDRHIEQLTTASEHCDLAIKTVEEIEGV 390

  Fly   214 CSTTSVGNVAHKPPELSH-KGQVEALQEEVLHLRARIALLQSEISTKDA---AVVEEQTKVAFDC 274
            .......|:|.   |.|. :.::..|:||...|.|.:...:.|::...|   |:.||:.::
Mouse   391 LGRDLYPNLAE---ERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRL---- 448

  Fly   275 ESEVNECGQRLNDLNVCTSLTSPQKRIPA---------------------VPKMAERVKL-RCAS 317
            ...|.|...||..:. .|..:||.:..||                     :.|:|||||| :..|
Mouse   449 RRRVRELQTRLQSVQ-ATGPSSPGRLTPANRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRS 512

  Fly   318 KHESGEDPSQDTSLSNEQI--NLVEHLVSELKE--------QNLYMENFMEPLHLSK------DL 366
            :..|.:.|...:.:|:..:  ::.|||...|::        |.||...  ..:..||      :.
Mouse   513 ESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHG--SAISESKIREFEVET 575

  Fly   367 ERLQRRVEQLEMRNTMLALTLDECKEHTEHLYLLCGKYESNAVALQLALNCSDRAIEAYDVMLAL 431
            |||..|:|.|:.:|.:|.:||:|||.:.|.:.:|.|||||||.||:|||..|::.||||:::|||
Mouse   576 ERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLAL 640

  Fly   432 LESKLALL-----------------GEKSVA-----AEESRRSVEAVARHLLARLDSEKN----V 470
            .||:.:|:                 |::::.     |.:.|::.|..|:.||.:||....    |
Mouse   641 AESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV 705

  Fly   471 CENSLGPWQ-----HNINLGPEDAPKTGRPWCADDDNRLRYHVSKLKGRRSNVQHTIVSLES--- 527
            ...|:.||:     .:.:.....|......:..:|:.||:.::.:||..|:.|:.|::.|||
Mouse   706 AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHI 770

  Fly   528 -PFSDIYERKRLALEKEHELRSADKKSPIDLETAVIMQEILELRDSNLQLKTKMEEAEQER---- 587
             |.|             ::::.......:|||.||:|||::.:::...:||.::...|:|:
Mouse   771 DPLS-------------YDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALE 822

  Fly   588 -----QNANERVGILH--------EALKQLQANNRVSYS------------EAEHAALTEQQL-- 625
                 :.|.|:..::|        |..|:.:..:..|.|            :|...||:..:|
Mouse   823 LKLSTREAQEQAYLVHIEHLKSEVEEQKEQRTRSLSSTSSSGKEKPGKECADAASPALSLAELRT 887

  Fly   626 ----------VEALTRETELKGRIQTLLANVTASQKAFDEKYEQLHQNVRELQKSNHNLGQMLDH 680
                      ..|:.||.:||.|:|.|::.:....|:.:.:::|..:.|.:|:::|.||....:.
Mouse   888 NSDSELATEFANAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEK 952

  Fly   681 TKRKYQLRVRKLEQKIVDL----------------RLDYEQGHNHVPETTL 715
            .|:|:|.:::|||.:::.:                .|:.|....|..||:|
Mouse   953 AKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34404	NP_650457.2	SCP-1	<99..599	CDD:114219	167/679 (25%)
		MCC-bdg_PDZ	368..432	CDD:287477	33/63 (52%)
		WXG100	609..696	CDD:295131	27/110 (25%)
Mcc	NP_001078842.1	EFh	24..80	CDD:238008
		EF-hand_7	25..78	CDD:290234
		FAM76	<146..271	CDD:292665	31/131 (24%)
		MCC-bdg_PDZ	577..640	CDD:287477	32/62 (52%)
		MCC-bdg_PDZ	906..972	CDD:287477	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850372
Domainoid	1	1.000	74	1.000	Domainoid score	I9170
eggNOG	1	0.900	-	-		E1_2CMBN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009302
OrthoInspector	1	1.000	-	-		oto93220
orthoMCL	1	0.900	-	-		OOG6_110033
Panther	1	1.100	-	-	LDO	PTHR23347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5133
SonicParanoid	1	1.000	-	-		X7039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.820