DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34404 and mcc

DIOPT Version :9

Sequence 1:	NP_650457.2	Gene:	CG34404 / 41873	FlyBaseID:	FBgn0085433	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_021332393.1	Gene:	mcc / 100537329	ZFINID:	ZDB-GENE-141210-1	Length:	1013	Species:	Danio rerio

Alignment Length:	962	Identity:	236/962 - (24%)
Similarity:	380/962 - (39%)	Gaps:	309/962 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ATDVPRRSGKQRDSSGFQGKHSGSAAGEDFEYVFGSISPRGGGPGGRHLVGSSDLDSPE------ 72
            ::|..::..::|.:|......:...|.|.:|  |.|              |:.||.|||
Zfish   101 SSDSDKQKLRERIASWPTSSENSLGARESWE--FDS--------------GARDLQSPELQSPTQ 149

  Fly    73 ----------HTQRDTTESDNNISSCSTLDIVNKVEQLSVQ----------------------QL 105
                      |.|:.:......:...|.|:..:.|:||..|                      .|
Zfish   150 THPHLHPHLHHHQQSSPLLQKLLEQPSVLEPSSGVQQLLCQPAFSRSGGYLELANTLHLAALASL 214

  Fly   106 ENRVRDLTQRLQQAERQLTESNTEREICHKRLEVV--SQAH----------------ECRITEMH 152
            :..|.:|.|||.|.||       ||:...|||...  .|:|                |.||||:|
Zfish   215 KGDVLELNQRLLQTER-------ERDALEKRLTTAQCEQSHLLREHEEVQERTTLCYEERITELH 272

  Fly   153 CVIAELSKKLRSKQDHVIMEE-------------------------QEPDGSELSFQEG------ 186
            .:||||:||:...|...|.||                         |:||.:.||..|.
Zfish   273 SIIAELNKKIDLLQGATIREEDEFSELRSDLSHSQQEVNEDERSVDQDPDQASLSLPENQSMLVT 337

  Fly   187 ------SVYNSEL-------------------------------NLTNPDAECQ--TEPLEDFEG 212
                  |..||||                               .||.....|.  .:.:|:.||
Zfish   338 ADMDNCSDLNSELQRVLTGLESVLCGRKKSTCSLSVAEVDRHIEQLTTASQHCDLAIKTVEEIEG 402

  Fly   213 A---------C------------------STTSVGNVAHKPPELSH-KGQVEALQEEVLHLRARI 249
            |         |                  |.|::  :..|..:|:. |..:.|::||...||.|:
Zfish   403 ALGHDFYPSLCEERVRWEKELAGLRDENESLTAM--LCSKEEDLNRTKASLNAIREERDRLRRRV 465

  Fly   250 ALLQSEISTKDAAVVEEQTKVAFDCESEVNECGQRLNDLNVCTSLTSPQKRIPAVPKMAERVKLR 314
            ..:|:.:.:....        |......:...|:.:|......|.:|....|| :.|:||||||
Zfish   466 REMQTRLQSVQPG--------APPSPGRLTPAGRPINPSTGELSTSSSSNDIP-IAKVAERVKL- 520

  Fly   315 CASKHESGEDPSQDTSLSNE------QINLVEHLVSELKE--------QNLYMENFMEPLHLSK- 364
              ||..|...|::.:.|.:|      ..|:.|||...|::        |.||...  ..:..||
Zfish   521 --SKTRSESLPTERSILGSEISSIGVSSNVAEHLAHSLQDCSNIQEIFQTLYSHG--SAISESKI 581

  Fly   365 -----DLERLQRRVEQLEMRNTMLALTLDECKEHTEHLYLLCGKYESNAVALQLALNCSDRAIEA 424
                 :.|||..|:|.|:.:|.:|.:||:|||.:.|.:.:|.||||||:.||:|||..|::.|||
Zfish   582 REFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLLGKYESNSTALRLALQYSEQCIEA 646

  Fly   425 YDVMLALLESKLALL----------------GEKSVA-----AEESRRSVEAVARHLLARLDSEK 468
            |:::|||.||:..|:                ||:|::     |.:||::.|..|:.||.|||...
Zfish   647 YELLLALAESEQGLVLGQFRAAGVSAVGEHAGEESISQLLKKAHDSRKTAENAAKDLLTRLDGSC 711

  Fly   469 N----VCENSLGPWQ-----HNINLGPEDAPKTGRPWCADDDNRLRYHVSKLKGRRSNVQHTIVS 524
            .    |...|..||:     .:.:.....|......:..:|:.||:.:|.:||..|:.|:.|::.
Zfish   712 GAAFAVTGCSAQPWESLSSNSHTSTTSSTASSCDTDFSKEDEQRLKDYVQQLKNDRAAVKLTMLD 776

  Fly   525 LESPFSDIYERKRLALEKEHELRSADKKSPIDLETAVIMQEILELRDSNLQLKTKMEEAEQER-- 587
            |||...:       .|..|...|.......:|||.||:|||::.:::...:||.::...|:|:
Zfish   777 LESVHIE-------PLSPELRTRGGGDAQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKA 834

  Fly   588 -------QNANERVGILHEALKQLQANNRVSYSEAEHAALTE----------------------- 622
                   :.|.|:..::|  ::.|:|... .:.|..|.|||.
Zfish   835 LELKLSSREAQEQAYLVH--IEHLKAELE-EHQEQRHTALTSTSTCSSSSKDCGDSPSVSVCDLR 896

  Fly   623 --------QQLVEALTRETELKGRIQTLLANVTASQKAFDEKYEQLHQNVRELQKSNHNLGQMLD 679
                    .:|..||.||.:||.|:|.|::.:....|:.:.:::|..:.|.:|:::|.||....:
Zfish   897 NLSDGDLAAELTGALRREKKLKARVQELVSALERLTKSSEVRHQQSAEFVNDLKRANSNLVAAYE 961

  Fly   680 HTKRKYQLRVRKLEQKIVDL----------------RLDYEQGHNHVPETTL 715
            ..|:|:|.:::|||.:::.:                .|:.|....|..||:|
Zfish   962 KAKKKHQNKLKKLECQMMAMVERHDTQVRMLKQRITLLEEETCRPHTNETSL 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34404	NP_650457.2	SCP-1	<99..599	CDD:114219	180/696 (26%)
		MCC-bdg_PDZ	368..432	CDD:287477	32/63 (51%)
		WXG100	609..696	CDD:295131	28/117 (24%)
mcc	XP_021332393.1	EF-hand_7	25..79	CDD:316058
		SMC_N	<211..>453	CDD:330553	56/250 (22%)
		MCC-bdg_PDZ	590..653	CDD:313686	31/62 (50%)
		APG6	754..>867	CDD:309295	32/122 (26%)
		MCC-bdg_PDZ	916..982	CDD:313686	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596292
Domainoid	1	1.000	73	1.000	Domainoid score	I9231
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	177	1.000	Inparanoid score	I4035
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140333at33208
OrthoFinder	1	1.000	-	-		FOG0009302
OrthoInspector	1	1.000	-	-		oto40687
orthoMCL	1	0.900	-	-		OOG6_110033
Panther	1	1.100	-	-	LDO	PTHR23347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900