DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34404 and mcc

DIOPT Version :9

Sequence 1:	NP_650457.2	Gene:	CG34404 / 41873	FlyBaseID:	FBgn0085433	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_012812941.1	Gene:	mcc / 100216150	XenbaseID:	XB-GENE-953990	Length:	1006	Species:	Xenopus tropicalis

Alignment Length:	924	Identity:	229/924 - (24%)
Similarity:	381/924 - (41%)	Gaps:	271/924 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SGKQRDSSGFQGKHSGSAAGEDFEYVFGSISPRGGGPGGRHLVGS-SDLDSPEHTQ-------RD 77
            :|.:.....|.|      |.|.:||..|:...:...|....::.. .:..|...||       ..
Frog   125 TGSENSIGAFSG------ARESWEYDSGARDLQSPDPQNHSIMQKFLEFGSKATTQAALQKLLSQ 183

  Fly    78 TTESDNNISSCSTLDIVNKVEQLSVQQLENRVRDLTQRLQQAERQLTESNTEREICHKRL--EVV 140
            |:.|.||:.. |.|::.|.:...::..|...:.:|.:||||.||       ||::..|:|  ...
Frog   184 TSSSSNNMGG-SYLELANTLHLAALASLRGDIVELNKRLQQTER-------ERDMLEKKLAKSQC 240

  Fly   141 SQAH----------------ECRITEMHCVIAELSKKLRSKQDHVIMEEQE-------------- 175
            .|||                |.||||:|.:||||:||:...|...|.||.|
Frog   241 EQAHLMREHEDVQERTTLRYEERITELHSIIAELNKKIDRLQGTTIREEDEYSELRSEHSHSQLE 305

  Fly   176 ---------PDGSELSFQEG------------SVYNSEL-------------------NLTNPDA 200
                     .|.:.:|.||.            |..||||                   ||:..|.
Frog   306 TNDDSRSMDQDQTSVSVQENQSTMVTVDMDTCSDLNSELQRVLTGLENAICGRKKSSCNLSVADV 370

  Fly   201 ECQTEPL--------------EDFEGACSTTSVGNVAH-------------------------KP 226
            :...|.|              |:.||........|:|.                         |.
Frog   371 DRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNIAEERSRWEKELAGLREENESLTAMLCSKE 435

  Fly   227 PELSH-KGQVEALQEEVLHLRARIALLQSEISTKDAAVVEEQTKVAFDCESEVNECGQRLNDLNV 290
            .:|:. |..:.|::||...||.|:..||:.:.:..|.......::. .....||.....|
Frog   436 EDLNRTKATMNAIREERDRLRRRVRELQTRLQSIQATGPSSPGRLT-SASRPVNPSTGEL----- 494

  Fly   291 CTSLTSPQKRIPAVPKMAERVKL-RCASKHESGEDPSQDTSLSNEQI--NLVEHLVSELKE---- 348
              |.:|....|| :.|:|||||| :..|:..|.|.|...:.:|:..:  ::.|||...|::
Frog   495 --STSSSSNDIP-IAKIAERVKLSKTRSESSSSERPVLGSEISSIGVSSSVAEHLAHSLQDCSNI 556

  Fly   349 ----QNLYMENFMEPLHLSK------DLERLQRRVEQLEMRNTMLALTLDECKEHTEHLYLLCGK 403
                |.||...  ..:..||      :.|||..|:|.|:.:|.:|.:||:|||.:.|.:.:|.||
Frog   557 QEIFQTLYSHG--SAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGK 619

  Fly   404 YESNAVALQLALNCSDRAIEAYDVMLALLESKLALL---------------GEKSVA-----AEE 448
            |||||.||:|||..|::.||||:::|||.||:.:|:               |:::|.     |.:
Frog   620 YESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSVAESGDENVTQMLKRAHD 684

  Fly   449 SRRSVEAVARHLLARLDSEKN----VCENSLGPWQ-----HNINLGPEDAPKTGRPWCADDDNRL 504
            .|::.|..|:.||.:||....    |...|:.||:     .:.:.....|......:..:|:.||
Frog   685 CRKTAENAAKALLMKLDGSCGGAFAVTGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRL 749

  Fly   505 RYHVSKLKGRRSNVQHTIVSLES----PFSDIYERKRLALEKEHELRSADKKSPIDLETAVIMQE 565
            :.::.:||..|:.|:.|::.|||    |.|             ::::.......:|||.||:|||
Frog   750 KDYIQQLKNDRAAVKLTMLELESIHIDPLS-------------YDVKPRGDSQRLDLENAVLMQE 801

  Fly   566 ILELRDSNLQLKTKMEEAEQER---------QNANERVGILH-EALK---QLQANNRV------- 610
            ::.:::...:||.::...|:|:         ::|.|:..::| |.||   :.|...|:
Frog   802 LMAMKEEMAELKAQLYLLEKEKKALELKLSTRDAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTS 866

  Fly   611 -----------------------SYSEAEHAALTEQQLVEALTRETELKGRIQTLLANVTASQKA 652
                                   :|:|:|.|:    :|..||.||.:||.|.|.|::.:....|:
Frog   867 SSSKDKLGKDSTEGSALSLSELRTYNESELAS----ELTSALRREKKLKSRAQELVSALERLTKS 927

  Fly   653 FDEKYEQLHQNVRELQKSNHNLGQMLDHTKRKYQLRVRKLEQKIVDL----------------RL 701
            .:.:::|..:.|.:|:::|.||....:..|:|:|.:::|||.:::.:                .|
Frog   928 SEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALL 992

  Fly   702 DYEQGHNHVPETTL 715
            :.|....|..||:|
Frog   993 EEENSRPHTNETSL 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34404	NP_650457.2	SCP-1	<99..599	CDD:114219	172/671 (26%)
		MCC-bdg_PDZ	368..432	CDD:287477	33/63 (52%)
		WXG100	609..696	CDD:295131	28/116 (24%)
mcc	XP_012812941.1	EF-hand_7	32..88	CDD:372618
		SMC_prok_A	<207..>447	CDD:274009	54/246 (22%)
		MCC-bdg_PDZ	584..647	CDD:371100	32/62 (52%)
		Smc	<738..>998	CDD:224117	62/276 (22%)
		MCC-bdg_PDZ	909..975	CDD:371100	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9036
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I3833
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140333at33208
OrthoFinder	1	1.000	-	-		FOG0009302
OrthoInspector	1	1.000	-	-		otm48347
Panther	1	1.100	-	-	LDO	PTHR23347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5133
SonicParanoid	1	1.000	-	-		X7039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100