Protein Alignment Cog2 and Cog2

DIOPT Version :9

• Sequence 1: NP_524366.1
• Gene: Cog2 / 41870
• FlyBaseID: FBgn0026634
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_006255878.1
• Gene: Cog2 / 690961
• RGDID: 1589822
• Length: 741
• Species: Rattus norvegicus
• Alignment Length: 735
• Identity: 235/735 - (31%)
• Similarity: 387/735 - (52%)
• Gaps: 78/735 - (10%)

  Fly     6 KKSAHLTAGSTSTAEKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDL 70
            |:..:|..|    .:.|||||:||||.:|.||.|:...|....||:|||:|.||.|.|:.||::|
  Rat     3 KRRMNLPTG----PDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVEL 63

  Fly    71 INEDYADFVNLSANLVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKR 135
            ||:|||||||||.||||:|:.:..:..||.|.|.::.|:...:.|.:..:..::.::..:|:.|.
  Rat    64 INKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGILAVEERMSKQDDIRKKKM 128

  Fly   136 GLQSLKKVYETINKLQDLIDRKLSGEQPIKAVD--------LERAALDLIQLKFHEKH-----CF 187
            .:..|.:|..::.|::.:::.:.|.:...:...        |||.|.:..||:||...     ..
  Rat   129 SVLRLIQVIRSVEKIEKILNSQSSKDASSQEASSPLLTGQVLERIATEFNQLQFHAVQSKGMPLL 193

  Fly   188 KHLSPDHQGKIQQLEEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDV 252
            ..:.|...|....|::.|...|       |...:.|..:.:..|||.|.|::....||....:.:
  Rat   194 DKVRPRIAGITAMLQQSLEGLL-------LEGLQTSNVDIIRHCLRTYATIDKTRDAEALVGQVL 251

  Fly   253 VAPYMTGVIGEQQLQNSPQGLAGIYSKILNFISLHMTDLLRLT---LYSDK---FPGFNFVVNSY 311
            |.||::.||.|:.:.:.|.||..:|:|:|.|:..|...|..:|   :.|:|   .||::|:|||.
  Rat   252 VKPYVSEVIVERVVDSHPSGLQLMYNKLLEFVPHHCRLLREVTGGAVSSEKGTIVPGYDFLVNSV 316

  Fly   312 WSDVETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEAR 376
            |.::...||..:.|:|.||:.:.|:.||..:.||:.:.|.  .|..:.:|...|.|....||..:
  Rat   317 WPEIVGGLEEKLPSLFNPGDPDAFHQKYTVSMDFVRRFER--QCGSQASVKRLRAHPAYHSFSNK 379

  Fly   377 WNLPVYFQICFQEIAGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEV 441
            |||||||||.|:|:||..||.|     .|.|:|....|.|.:.|.:....::::||::.::||.:
  Rat   380 WNLPVYFQIRFREVAGSLEASL-----TDGLEDAPAGSPYCLLASHRTWISLSKCWSDEMFLPLL 439

  Fly   442 FPKFYKLNVQVVLRLSRWITD----------------AITQSK------GSNFSK----PYTRNQ 480
            ..:.::|.:|::.|.|.::::                .:..||      ||:.|:    |.:..|
  Rat   440 AHRLWRLTLQILARFSVFVSELSVRPISNETAKETKKPLAGSKDPSDDHGSHPSEAGAVPISSTQ 504

  Fly   481 LLIALHADIRKLDAHLPELQQLI---IKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTL 542
            |:..: :|:.:|...||:|.:.:   ::.|..:..:.| |..|..|.|.|:    ||:..:...:
  Rat   505 LVYVV-SDLGRLQEWLPDLLETVRLKLEMVGFKNFSSI-SAALEDSQSALS----AHVPALSSRI 563

  Fly   543 VELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQIL 607
            |:.|...| ...::...::|||||:||:|||:..||||:..|:||......:..::...|:::.|
  Rat   564 VQDLSESC-FGYLKSALEVPRLYRRTNKEVPSTASSYVDSALKPLYQLQSGHGDKVQPAVMQRWL 627

  Fly   608 AEVASHITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDV 672
            .|..|..|..||..|||||:||:|.||||:||:..:. ..||....||..||||||||:||.:||
  Rat   628 QEALSDSTHKYFETVSDVLSSVRKMEESLKRLKQARR-SPATNPVSSSGGMSDDDKIRLQLALDV 691

  Fly   673 TSWRQEL----CKLNFQATQ 688
            ....:::    .:...||:|
  Rat   692 EHLGEQVPATRARFEGQASQ 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog2	NP_524366.1	COG2	22..154	CDD:283743	54/131 (41%)
		DUF3510	546..672	CDD:288845	54/125 (43%)
Cog2	XP_006255878.1	COG2	15..147	CDD:283743	53/131 (40%)
		DUF3510	566..691	CDD:288845	51/124 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342169
Domainoid	1	1.000	152	1.000	Domainoid score	I4237
eggNOG	1	0.900	-	-		E1_KOG2307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7206
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2191
OMA	1	1.010	-	-		QHG55570
OrthoDB	1	1.010	-	-		D190117at2759
OrthoFinder	1	1.000	-	-		FOG0006036
OrthoInspector	1	1.000	-	-		oto96886
orthoMCL	1	0.900	-	-		OOG6_102642
Panther	1	1.100	-	-	LDO	PTHR12961
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4329
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770