DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog2 and cog2

DIOPT Version :9

Sequence 1:	NP_524366.1	Gene:	Cog2 / 41870	FlyBaseID:	FBgn0026634	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_998519.1	Gene:	cog2 / 406663	ZFINID:	ZDB-GENE-040426-2671	Length:	730	Species:	Danio rerio

Alignment Length:	737	Identity:	231/737 - (31%)
Similarity:	388/737 - (52%)	Gaps:	80/737 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSAN 84
            :.|||||:||||.:|.||:|:...|....||::|::|..|.:.|:.||::|||:|||||||||.|
Zfish     9 DSLCFDKDEFMKDDFDVDKFVADCRKRVQLEEMREDLEQYYRLLKTAMVELINKDYADFVNLSTN 73

  Fly    85 LVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINK 149
            |||:|:.:..:..||.|.|.::.|:...::|.:..:..||.::..:::.|..:..|.:|..::.|
Zfish    74 LVGMDKALNQLSIPLGQLREEVLSLRSSVNEVIEAIDTQLSKQDDIQKKKLCVLRLIQVVRSVEK 138

  Fly   150 LQDLIDR------KLSGEQPIKAVD-LERAALDLIQLKFHEKH-----CFKHLSPDHQGKIQQLE 202
            ::.::.:      .|....|:.|.. |||.|.:..||:||...     ....:.|...|....|:
Zfish   139 IEKILHQNTKDTTSLETSSPLLAGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQ 203

  Fly   203 EQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQ 267
            :.|...|       :...:.|..:.:..|||.|.|::....||....:.:|.|||..||.||.::
Zfish   204 QSLEGLL-------IQGLQTSNIDIVRHCLRTYATIDKTRDAEALVGQVLVKPYMDEVIVEQFVK 261

  Fly   268 NSPQGLAGIYSKILNFISLHMTDLLRLT---LYSDK---FPGFNFVVNSYWSDVETRLELHMNSI 326
            :||.||..:|:|:|.|:..|...|..:|   :.|||   .||::|:|||.|.::...:|..:.|:
Zfish   262 SSPNGLKVMYAKLLEFVPHHCRLLREVTGGAISSDKADIVPGYDFLVNSVWPEIIRGVEERVPSL 326

  Fly   327 FAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEIA 391
            |.|||.:|||.:|..:.||:.|.|.  .|..:.:|...|.|...:||..:||||||||:.|:|||
Zfish   327 FNPGNPDVFYERYTVSMDFVRKFER--QCGSQASVKRLRAHPSYQSFHNKWNLPVYFQLRFKEIA 389

  Fly   392 GKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRL 456
            |..|:.:     .|.|:.....|.:.:.........:.|||.:.||||.:..:|:||.:|::.|.
Zfish   390 GSLESAI-----ADGLEATPVGSSFHLQVTEVLWSCVCRCWTDQVYLPPLAHRFWKLTLQLISRY 449

  Fly   457 SRWITDAITQSKGSNFSKPYTR----------------------------NQLLIALHADIRKLD 493
            |.::|:.:|::..:..||...|                            .:.|:.:.||:.||.
Zfish   450 STFLTEVLTKTSSTEASKDSVRPLPSSASSTSSRTSQDADSETGGPTVLSTKQLVFIAADVDKLQ 514

  Fly   494 AHLPELQQLI---IKSVPVEQCTKIFSDVL---AKSMSCLADTLGAHLT-NIQKTLVELLIGECE 551
            ..:|::.::|   ::::..:... |.|:.|   :.|:|....||.:.:| ::.:..|..|
Zfish   515 GKIPDISEMIKAKLENIGFQNFA-IVSEALQDSSTSLSSCVPTLNSRMTQHLTERSVRFL----- 573

  Fly   552 TENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASHITK 616
                :..:::|||||:||:|||||.|:|::..||||......:::.:...::::.|....|..|.
Zfish   574 ----KNASEVPRLYRRTNKEVPTRASAYMDNALRPLHQLVTDSKNVVKDSIIQEWLQVTLSDCTH 634

  Fly   617 AYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVST-GSSAVMSDDDKIRVQLRVDVTSWRQELC 680
            .||..:||||:||:|.||||:||:..:.  ..|.|| |.:|..|||.|||:||.:||....:::.
Zfish   635 RYFETISDVLSSVRKMEESLKRLKQARK--TTTTSTVGVNAGPSDDSKIRLQLALDVEYLGEQIE 697

  Fly   681 KLNFQATQIDKLVELTNMVEDS 702
            .:..|.:.|.....|..:|:::
Zfish   698 NMGLQPSDITMFSSLLELVQEA 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog2	NP_524366.1	COG2	22..154	CDD:283743	51/131 (39%)
Cog2	NP_524366.1	DUF3510	546..672	CDD:288845	50/126 (40%)
cog2	NP_998519.1	COG2	11..143	CDD:283743	51/131 (39%)
cog2	NP_998519.1	DUF3510	564..689	CDD:288845	51/135 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582218
Domainoid	1	1.000	173	1.000	Domainoid score	I3651
eggNOG	1	0.900	-	-		E1_KOG2307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7206
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2169
OMA	1	1.010	-	-		QHG55570
OrthoDB	1	1.010	-	-		D190117at2759
OrthoFinder	1	1.000	-	-		FOG0006036
OrthoInspector	1	1.000	-	-		oto41664
orthoMCL	1	0.900	-	-		OOG6_102642
Panther	1	1.100	-	-	LDO	PTHR12961
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2461
SonicParanoid	1	1.000	-	-		X4329
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800