DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog2 and COG2

DIOPT Version :9

Sequence 1:	NP_524366.1	Gene:	Cog2 / 41870	FlyBaseID:	FBgn0026634	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_031383.1	Gene:	COG2 / 22796	HGNCID:	6546	Length:	738	Species:	Homo sapiens

Alignment Length:	736	Identity:	242/736 - (32%)
Similarity:	385/736 - (52%)	Gaps:	78/736 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSAN 84
            :.|||||:||||.:|.||.|:...|....||:|||:|.||.|.|:.||::|||:|||||||||.|
Human    13 DTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTN 77

  Fly    85 LVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINK 149
            |||:|:.:..:..||.|.|.::.|:...:.|.:..:..::.::..:|:.|..:..|.:|..::.|
Human    78 LVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEK 142

  Fly   150 LQDLIDRKLSGE-------QPIKAVD-LERAALDLIQLKFHEKH-----CFKHLSPDHQGKIQQL 201
            ::.:::.:.|.|       .|:.... |||.|.:..||:||...     ....:.|...|....|
Human   143 IEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAML 207

  Fly   202 EEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQL 266
            ::.|...|       |...:.|..:.:..|||.|.|::....||....:.:|.||:..||.||.:
Human   208 QQSLEGLL-------LEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFV 265

  Fly   267 QNSPQGLAGIYSKILNFISLHMTDLLRLT---LYSDK---FPGFNFVVNSYWSDVETRLELHMNS 325
            ::.|.||..:|:|:|.|:..|...|..:|   :.|:|   .||::|:|||.|..:...||..:.|
Human   266 ESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPS 330

  Fly   326 IFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEI 390
            :|.|||.:.|:.||..:.||:.::|.  .|..:.:|...|.|....||..:|||||||||.|:||
Human   331 LFNPGNPDAFHEKYTISMDFVRRLER--QCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREI 393

  Fly   391 AGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLR 455
            ||..||.|     .|.|:|...:|.|.:.|.:....::.|||::.::||.:..:.::|.:|::.|
Human   394 AGSLEAAL-----TDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILAR 453

  Fly   456 LSRWITD-------------------------AIT------QSKGSNFSKP---YTRNQLLIALH 486
            .|.::.:                         :||      |..|.:.:||   .:|.||:..:
Human   454 YSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVV- 517

  Fly   487 ADIRKLDAHLPELQQLI---IKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIG 548
            ||:.||...||||.::|   ::.:..:..:.| |..|..|.|    :..|.:.::...:::.|..
Human   518 ADLDKLQEQLPELLEIIKPKLEMIGFKNFSSI-SAALEDSQS----SFSACVPSLSSKIIQDLSD 577

  Fly   549 ECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASH 613
            .| ...::...::|||||:||:||||..||||:..|:||......::.:|...:::|.|....|.
Human   578 SC-FGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSE 641

  Fly   614 ITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQE 678
            .|..|:..|||||.||:|.||||:||:..:....|. ..|.|..||||||||:||.:||....::
Human   642 STHKYYETVSDVLNSVKKMEESLKRLKQARKTTPAN-PVGPSGGMSDDDKIRLQLALDVEYLGEQ 705

  Fly   679 LCKLNFQATQIDKLVELTNMV 699
            :.||..||:.|.....|..:|
Human   706 IQKLGLQASDIKSFSALAELV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog2	NP_524366.1	COG2	22..154	CDD:283743	54/131 (41%)
Cog2	NP_524366.1	DUF3510	546..672	CDD:288845	53/125 (42%)
COG2	NP_031383.1	COG2	15..147	CDD:310616	54/131 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..504		4/29 (14%)
		DUF3510	574..699	CDD:314835	53/126 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..687		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148296
Domainoid	1	1.000	161	1.000	Domainoid score	I4007
eggNOG	1	0.900	-	-		E1_KOG2307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7206
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2214
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55570
OrthoDB	1	1.010	-	-		D190117at2759
OrthoFinder	1	1.000	-	-		FOG0006036
OrthoInspector	1	1.000	-	-		oto89771
orthoMCL	1	0.900	-	-		OOG6_102642
Panther	1	1.100	-	-	LDO	PTHR12961
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2461
SonicParanoid	1	1.000	-	-		X4329
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800