Protein Alignment Cog2 and COG2

DIOPT Version :10

• Sequence 1: NP_524366.1
• Gene: Cog2 / 41870
• FlyBaseID: FBgn0026634
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_031383.1
• Gene: COG2 / 22796
• HGNCID: 6546
• Length: 738
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 242/736 - (32%)
• Similarity: 385/736 - (52%)
• Gaps: 78/736 - (10%)

  Fly    20 EKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSAN 84
            :.|||||:||||.:|.||.|:...|....||:|||:|.||.|.|:.||::|||:|||||||||.|
Human    13 DTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTN 77

  Fly    85 LVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINK 149
            |||:|:.:..:..||.|.|.::.|:...:.|.:..:..::.::..:|:.|..:..|.:|..::.|
Human    78 LVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEK 142

  Fly   150 LQDLIDRKLSGE-------QPIKAVD-LERAALDLIQLKFHEKH-----CFKHLSPDHQGKIQQL 201
            ::.:::.:.|.|       .|:.... |||.|.:..||:||...     ....:.|...|....|
Human   143 IEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAML 207

  Fly   202 EEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQL 266
            ::.|...|       |...:.|..:.:..|||.|.|::....||....:.:|.||:..||.||.:
Human   208 QQSLEGLL-------LEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFV 265

  Fly   267 QNSPQGLAGIYSKILNFISLHMTDLLRLT---LYSDK---FPGFNFVVNSYWSDVETRLELHMNS 325
            ::.|.||..:|:|:|.|:..|...|..:|   :.|:|   .||::|:|||.|..:...||..:.|
Human   266 ESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPS 330

  Fly   326 IFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEI 390
            :|.|||.:.|:.||..:.||:.::|.  .|..:.:|...|.|....||..:|||||||||.|:||
Human   331 LFNPGNPDAFHEKYTISMDFVRRLER--QCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREI 393

  Fly   391 AGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLR 455
            ||..||.|     .|.|:|...:|.|.:.|.:....::.|||::.::||.:..:.::|.:|::.|
Human   394 AGSLEAAL-----TDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILAR 453

  Fly   456 LSRWITD-------------------------AIT------QSKGSNFSKP---YTRNQLLIALH 486
            .|.::.:                         :||      |..|.:.:||   .:|.||:..:
Human   454 YSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVV- 517

  Fly   487 ADIRKLDAHLPELQQLI---IKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIG 548
            ||:.||...||||.::|   ::.:..:..:.| |..|..|.|    :..|.:.::...:::.|..
Human   518 ADLDKLQEQLPELLEIIKPKLEMIGFKNFSSI-SAALEDSQS----SFSACVPSLSSKIIQDLSD 577

  Fly   549 ECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASH 613
            .| ...::...::|||||:||:||||..||||:..|:||......::.:|...:::|.|....|.
Human   578 SC-FGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSE 641

  Fly   614 ITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQE 678
            .|..|:..|||||.||:|.||||:||:..:....|. ..|.|..||||||||:||.:||....::
Human   642 STHKYYETVSDVLNSVKKMEESLKRLKQARKTTPAN-PVGPSGGMSDDDKIRLQLALDVEYLGEQ 705

  Fly   679 LCKLNFQATQIDKLVELTNMV 699
            :.||..||:.|.....|..:|
Human   706 IQKLGLQASDIKSFSALAELV 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog2	NP_524366.1	COG2	22..154	CDD:399271	54/131 (41%)
		COG2_C	546..672	CDD:463434	53/125 (42%)
COG2	NP_031383.1	COG2	15..147	CDD:399271	54/131 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..504		4/29 (14%)
		COG2_C	573..699	CDD:463434	53/127 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..687		4/19 (21%)