Protein Alignment Cog2 and cogc-2

DIOPT Version :10

• Sequence 1: NP_524366.1
• Gene: Cog2 / 41870
• FlyBaseID: FBgn0026634
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_501092.1
• Gene: cogc-2 / 177473
• WormBaseID: WBGene00000585
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 761
• Identity: 170/761 - (22%)
• Similarity: 304/761 - (39%)
• Gaps: 209/761 - (27%)

  Fly    21 KLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSANL 85
            ||||:|..|.:.:|:|:.|::..|....|:.::.:|.||||.::.:||:|||:||||||:||:||
 Worm    23 KLCFNKTHFNREDFNVERFMNLARQKSDLKTIQQDLRLYLKSVQNSMIELINDDYADFVHLSSNL 87

  Fly    86 VGLDQNIKTIQQPL----EQFRSDIESIHGL---IDENVTELRAQLEEKRQLREFKRGLQSLKKV 143
            |.|..::..|:|.:    ::|:.......|:   |::...||.:..|::.::|:         ::
 Worm    88 VSLQDSLNKIEQDINRIWDEFKESTRESVGMAERIEQKCDELCSNREKQIEIRD---------RI 143

  Fly   144 Y--ETINKLQDLI---DRKLSGEQPIKAVDLERAALDLIQLKFHEKHCFKHLSPDHQGKIQQLEE 203
            |  ..|.||.:::   .||.|      |:.|::||....:||   ...|.|
 Worm   144 YFLVAIEKLSEMLLHPPRKCS------ALWLQKAASFASELK---GSTFPH-------------- 185

  Fly   204 QLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQN 268
                          |:..|:|.:         |.|:..:...||             .|.:....
 Worm   186 --------------SEEENAAEK---------IILSQLEAVLCA-------------EGVRSAAG 214

  Fly   269 SPQGLAGIYSKILNFISLH------MTDLLRLTLYSDKFPGFNFV------------VNSYWSD- 314
            ..|.|..|||.:....|.|      ::|||.....::|....|.:            :...|::
 Worm   215 DCQNLPLIYSILSLTESTHSLTALLVSDLLYAEFVNEKHDESNQLKLLKQVFESVKKMRETWAEK 279

  Fly   315 ---------------------VETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGE 358
                                 :.|.::..|.::..|.::.:|:..:..|::|:.......||
 Worm   280 MGTEHFRGNIRRFLDETLLTFILTFIDKCMGAVAVPSDTRLFHECFLLTQEFIDNWPSSHTC--- 341

  Fly   359 QAVTFYRQHKQTKSFEARWNLPVYFQI--------CFQEIAGKFEAQLEPVLQEDSLKDNLTDSD 415
                    ....||...::||.|||::        |.|.::.:..|  ||...|:  ::|.....
 Worm   342 --------RAMLKSIRDKFNLLVYFKLETHRFGKQCDQLMSPEMFA--EPETSEN--RENTPQLH 394

  Fly   416 YKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRLSRWITDAITQSKGSNFSKPYTRNQ 480
            ..:|  .|...|:...|::.||||.:..|.:...::::|:...|     :|:..:.|.:......
 Worm   395 CGVS--RAIITAIEHVWSDDVYLPPIVDKLWDFTLKLLLKHFSW-----SQTMKNYFMEEKRDWT 452

  Fly   481 LLIALHADIRKL-----DAHLPEL----QQLIIKSVPVEQC-TKIFSDVLAKSMSCLADTLGAHL 535
            .::.|.:|...|     |..|..:    ..:.:.:.|..|| ||     ..:|:..|.
 Worm   453 SMVTLRSDTGNLHQLVFDFALESIWGKFHDITVDTAPFGQCLTK-----HGRSIDSLC------- 505

  Fly   536 TNIQKTLVELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVE---QMLRPLKAFAQQNESQ 597
            ..|..:::| :..|...:.:.||:|:|:.||.|.:..||..|.||.   :|:..||
 Worm   506 VQIDDSIIE-MFSEVLHQEIAQVSDVPKQYRWTKKSPPTTHSKYVVTAIEMVENLK--------- 560

  Fly   598 LGTLVVEQILAEVASH-------ITKAYFNVV----SDVLTSVQKTEESLRRLRNVKSGGAATVS 651
                  |::..|...|       :..:.||..    ::||.||:.|..||.|.:.       ..:
 Worm   561 ------EKLCCEEHPHTDEIVRKVNLSAFNYFVGKGNEVLDSVEATGSSLSRFKR-------KTT 612

  Fly   652 TGSSAVMSDDDKIRVQLRVDVTSWRQELCKLNFQATQIDKLVELTN 697
            |.|.:.::|||||:.|:..|...:......|.|....:..|.|:.|
 Worm   613 TDSGSTVTDDDKIKQQIYHDAKYFLSYAENLVFSQADLTGLQEVVN 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog2	NP_524366.1	COG2	22..154	CDD:399271	45/140 (32%)
		COG2_C	546..672	CDD:463434	37/139 (27%)
cogc-2	NP_501092.1	COG2	24..156	CDD:399271	45/140 (32%)
		COG2_C	514..633	CDD:463434	38/141 (27%)