DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5044 and Hibch

DIOPT Version :9

Sequence 1:	NP_732020.2	Gene:	CG5044 / 41869	FlyBaseID:	FBgn0038326	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	XP_006244957.1	Gene:	Hibch / 301384	RGDID:	1308392	Length:	385	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	188/360 - (52%)
Similarity:	252/360 - (70%)	Gaps:	11/360 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MALSVRQSSSSVLATESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKS--LVIIKGTGD 98
            :.:|....::.||.......|:|.|||||.|||::|.|:|:||..|||.|:...  |:||||.|.
  Rat    26 LRMSKHTETAEVLLERRGCAGVITLNRPKLLNALSLNMIRQIYPQLKKWERDPDTFLIIIKGAGG 90

  Fly    99 KAFCAGGDVRALVEAGPTDE--SKSFFREEYSTNALIGNYKIPYIAIIDGITMGGGVGLSVHGKY 161
            ||||||||::||.||....:  |:..|||||..|..|.:.:.||:|:||||||||||||||||::
  Rat    91 KAFCAGGDIKALSEAKKAGQTLSQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQF 155

  Fly   162 RVASDRTLFAMPETAIGLFPDVGGSYFLPRLQGKLGLYLGLTGYRLRGADVYYSGIATHYCESSK 226
            |||::|:|||||||.|||||||||.|||||||||||.:|.|||:||:|.||:.:|||||:.:|.|
  Rat   156 RVATERSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVHRAGIATHFVDSEK 220

  Fly   227 IPDLETAL--LNCPDADDVPELLQKYHSP----PEKPFSLQPVLEQINKNFSADSVEGILENLQN 285
            :..||..|  |..|.|:||..:|:.||:.    .:|....:..:::||..|||::||.|||||:.
  Rat   221 LHVLEEELLALKSPSAEDVAGVLESYHAKSKMGQDKSIIFEEHMDKINSCFSANTVEQILENLRQ 285

  Fly   286 DGSEWAKKTLETLSKMSPTSMKVTFRQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLI 350
            |||.:|.:.::.::||||||:|:|.|||..||..:|.:.|.|||||....:|..||.|||||:||
  Rat   286 DGSPFAMEQIKVINKMSPTSLKITLRQLMEGSTKTLQEVLTMEYRLTQACMEGHDFHEGVRAVLI 350

  Fly   351 DKDQKPQWQPTKLADVTEEHVQWFFRKLPDTEELK 385
            ||||.|:|:|..|.|||:|.:..:|:.| .:.:||
  Rat   351 DKDQTPKWKPADLKDVTDEDLNSYFKSL-GSRDLK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5044	NP_732020.2	PRK05617	44..376	CDD:235533	183/341 (54%)
CG5044	NP_732020.2	ECH_2	56..374	CDD:292731	181/327 (55%)
Hibch	XP_006244957.1	PRK05617	33..377	CDD:235533	184/343 (54%)
Hibch	XP_006244957.1	ECH_2	46..374	CDD:292731	181/327 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346103
Domainoid	1	1.000	349	1.000	Domainoid score	I996
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5607
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2173
OMA	1	1.010	-	-		QHG63150
OrthoDB	1	1.010	-	-		D1369862at2759
OrthoFinder	1	1.000	-	-		FOG0001715
OrthoInspector	1	1.000	-	-		oto98889
orthoMCL	1	0.900	-	-		OOG6_102025
Panther	1	1.100	-	-	LDO	PTHR43176
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1442
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770