Protein Alignment Hibch and ECHS1

DIOPT Version :10

• Sequence 1: NP_732020.2
• Gene: Hibch / 41869
• FlyBaseID: FBgn0038326
• Length: 386
• Species: Drosophila melanogaster
• Sequence 2: NP_004083.3
• Gene: ECHS1 / 1892
• HGNCID: 3151
• Length: 290
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 75/257 - (29%)
• Similarity: 116/257 - (45%)
• Gaps: 52/257 - (20%)

  Fly    51 ESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKSL--VIIKGTGDKAFCAGGDVRALVEA 113
            :::..|:|.|||||||||:...::.::.:.||..|:..::  :::.| |||||.||.|::.:...
Human    43 KNNTVGLIQLNRPKALNALCDGLIDELNQALKTFEEDPAVGAIVLTG-GDKAFAAGADIKEMQNL 106

  Fly   114 GPTDESKSFFREEYSTNAL-----IGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMP 173
            .        |::.||:..|     :...|.|.||.::|...|||..|::......|.::..||.|
Human   107 S--------FQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKAQFAQP 163

  Fly   174 ETAIGLFPDVGGSYFLPRLQGK-LGLYLGLTGYRLRGADVYYSGIATHYCESSKIPDLETALLNC 237
            |..||..|..||:..|.|..|| |.:.:.|||.|:...|...:|:.      |||         |
Human   164 EILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLV------SKI---------C 213

  Fly   238 PDADDVPELLQKYHSPPEKPFSLQPVLEQINKN------FSADSVEGILENLQNDGSEWAKK 293
            |....|.|.:|              ..|:|..|      .:.:||....|....:||:..||
Human   214 PVETLVEEAIQ--------------CAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKK 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hibch	NP_732020.2	ECH_2	56..375	CDD:465024	75/252 (30%)
ECHS1	NP_004083.3	crotonase-like	32..288	CDD:474030	75/257 (29%)