DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5044 and Cdyl

DIOPT Version :9

Sequence 1:	NP_732020.2	Gene:	CG5044 / 41869	FlyBaseID:	FBgn0038326	Length:	386	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	317	Identity:	66/317 - (20%)
Similarity:	109/317 - (34%)	Gaps:	108/317 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MALSVRQSSSS-----------------VLATESSNKGMIILNRPKALNAINLEMVRKIYKHLKK 83
            :..||||:.|:                 :|:|:||..           |::|.|:::::...|..
Mouse   323 LRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSEN-----------NSLNPEVMKEVQSALST 376

  Fly    84 CEKSKSLVIIKGTGDKAFCAGGD----VRALVEAGPTDESKSFFREEYSTNALIGN-------YK 137
            .....|.:::.......||.|.|    :|.|     ||:.|   ||.......|.|       :|
Mouse   377 AAADDSKLVLLSAVGSVFCCGLDFIYFIRRL-----TDDRK---RESTKMADAIRNFVNTFIQFK 433

  Fly   138 IPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMPETAIGLFPDVGGSYFLPRLQGKLG----L 198
            .|.|..::|..:|.|..:........|:::..|..|.|..|..||...:...|::.|...    |
Mouse   434 KPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEML 498

  Fly   199 YLG--LTGYRLRG----ADVYYSGIATH---------------YCESSKIPDLETALLNCPDADD 242
            :.|  ||.....|    :.|::.|..|.               ..|.||      ||:.|
Mouse   499 FSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESK------ALVRC----- 552

  Fly   243 VPELLQKYHSPPEKPFSLQPVLEQINKN---------FSADSVEGILENLQNDGSEW 290
                            :::..|||.|:.         .||..::.:|:.||....|:
Mouse   553 ----------------NMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5044	NP_732020.2	PRK05617	44..376	CDD:235533	62/309 (20%)
CG5044	NP_732020.2	ECH_2	56..374	CDD:292731	57/280 (20%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223
		crotonase-like	339..535	CDD:119339	45/214 (21%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		57/277 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900