DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg4b and AT3G59950

DIOPT Version :9

Sequence 1:	NP_650452.1	Gene:	Atg4b / 41868	FlyBaseID:	FBgn0038325	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	NP_191554.1	Gene:	AT3G59950 / 825165	AraportID:	AT3G59950	Length:	477	Species:	Arabidopsis thaliana

Alignment Length:	509	Identity:	160/509 - (31%)
Similarity:	229/509 - (44%)	Gaps:	126/509 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 VSMESSITELPSGADTTPDNAT----SAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVE 251
            |:..|.:::|...|.|:..|..    |::..|..|::..|  .|:...| |.::.|...|:.:..
plant    50 VASSSPVSQLCREASTSGHNPVCTTHSSWTVILKTASMAS--GAIRRFQ-DRVLGPSRTGISSST 111

  Fly   252 NQV-----------GEQPWEEGIEG-----FRRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCML 300
            :::           ||.. ||...|     ||:||.|.|.|||||.|..:..:.||||..|||||
plant   112 SEIWLLGVCYKISEGESS-EEADAGRVLAAFRQDFSSLILMTYRRGFEPIGDTTYTSDVNWGCML 175

  Fly   301 RSGQMLFAQGLICHFLGRSWR-YDSESQLHSTYEDNMHKKIVKWFGDSSSKSSPFSIHALVRLGE 364
            |||||||||.|:...|||||| .|||.      .|..:.:|::.|||  :::|.||||.|:..||
plant   176 RSGQMLFAQALLFQRLGRSWRKKDSEP------ADEKYLEILELFGD--TEASAFSIHNLILAGE 232

  Fly   365 HLGKKPGDWYGPASVSYLLKHALEHAAQEN---ADFDNISVYVAKDCTIYLQD----------IE 416
            ..|...|.|.||    |.:..:.|..|::|   .|..:.|..:|.......:|          ||
plant   233 SYGLAAGSWVGP----YAVCRSWESLARKNKEETDDKHKSFSMAVHIVSGSEDGERGGAPILCIE 293

  Fly   417 DQCSIPEPAPKPHVPWQQAKRPQAETTKT-----EQQQHWKSLIVLIPLRLGSDKLNPVYAHCLK 476
            |                        .|||     |.:..|..:::|:||.||.|::||.|...|.
plant   294 D------------------------VTKTCLEFSEGETEWPPILLLVPLVLGLDRVNPRYIPSLI 334

  Fly   477 LLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQEN--FSLHSFHCKSPRKLK 539
            ...:....||||||||..|.|.||.|||:..:||||..|::|.|.:||  ....|:||.:.|.:.
plant   335 ATFTFPQSLGILGGKPGASTYIVGVQEDKGFYLDPHDVQQVVTVKKENQDVDTSSYHCNTLRYVP 399

  Fly   540 ASKMDPSCCIGFYCATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMN 604
            ...:|||..:||||..|.|||:|            |....   |.||..:              .
plant   400 LESLDPSLALGFYCQHKDDFDDF------------CIRAT---KLAGDSN--------------G 435

  Fly   605 YPLFSFSRGRCMDHERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQD 658
            .|||:.::    .|.|::..       |.:.:| :.|...:::    |:||:.|
plant   436 APLFTVTQ----SHRRNDCG-------IAETSS-STETSTEIS----GEEHEDD 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	125/326 (38%)
AT3G59950	NP_191554.1	Peptidase_C54	138..425	CDD:367485	125/334 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	191	1.000	Domainoid score	I940
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D431748at2759
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm3516
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	1	1.100	-	-	LDO	PTHR22624
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780