DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg4b and atg4c

DIOPT Version :9

Sequence 1:	NP_650452.1	Gene:	Atg4b / 41868	FlyBaseID:	FBgn0038325	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	XP_017948502.1	Gene:	atg4c / 493268	XenbaseID:	XB-GENE-941086	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	200/586 - (34%)
Similarity:	286/586 - (48%)	Gaps:	185/586 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 DLSANRTPTKGME---SKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESS 196
            |::...:.|..:|   ||.::.|||:||.|..|.: |.|.:..||:|||:|||.::.     :||
Frog    10 DINMEASGTDDVEKLKSKFLSAWHNMKYSWVLKTK-TYFKRNSPVFLLGKCYHFKYE-----DSS 68

  Fly   197 ITELPSGADTTPDNATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEE 261
            :|.         |..:::                               |.::.|:..|
Frog    69 VTS---------DGGSNS-------------------------------GSESKEDLSG------ 87

  Fly   262 GIEGFRRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWR----- 321
            .::.||:||.||||:|||.|||.:..|::|:||||||.||:||||.|||||.|||||.|.
Frog    88 NVDEFRKDFISRIWLTYREEFPQIETSSWTTDCGWGCTLRTGQMLLAQGLIVHFLGRDWTWTEAL 152

  Fly   322 --YDSESQ-------------LHSTYEDN----------------------MHKKIVKWFGDSSS 349
              :.|||:             |.:::.:|                      .|:||:.||.|  .
Frog   153 DIFSSESEFWTANTARKLTPSLETSFSENNECVSSNKQPLHNCDKKSNSEDFHQKIISWFAD--Y 215

  Fly   350 KSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFDNISVYVAKDCTIYLQD 414
            ..:.|.:|.||:||::.||..|||||||.||:||:.|:|.::  :.:...|::|||:|||||..|
Frog   216 PLAYFGLHQLVKLGKNSGKVAGDWYGPAVVSHLLRKAIEESS--DPELQGITIYVAQDCTIYSAD 278

  Fly   415 IED-QCSIPEPAPKPHVPWQQAKRPQAETTKTEQQQHWKSLIVLIPLRLGSDKLNPVYAHCLKLL 478
            :.| ||:                      ..||     |::::|:|:|||.::.|..|...:|.:
Frog   279 VYDLQCN----------------------KGTE-----KAVVILVPVRLGGERTNMEYFEFVKGI 316

  Fly   479 LSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENFSLHSFHCKSPRKLKASKM 543
            ||.|.|:||:|||||.|.||||||:|.||::||||||..|||:.:||.|.||||.||:|:...||
Frog   317 LSLEFCIGIIGGKPKQSYYFVGFQDDSLIYMDPHYCQSFVDVSVKNFPLESFHCPSPKKMSFKKM 381

  Fly   544 DPSCCIGFYCATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMNYPLF 608
            ||||.|||||....:|:...|.:...|                      :||     |:.|||||
Frog   382 DPSCTIGFYCRNAREFEKAAEELTKVL----------------------KSS-----TKQNYPLF 419

  Fly   609 SFSRGRCMDHERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQDDSE------SEEFVL 667
            :|..|...|.      |.:..|:..|                 .|...:|:.:      :|||||
Frog   420 TFVNGHAQDF------DFVCTPVYDQ-----------------NDLFTEDEKKRLKRFSTEEFVL 461

  Fly   668 L 668
            |
Frog   462 L 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	147/343 (43%)
atg4c	XP_017948502.1	Peptidase_C54	89..403	CDD:367485	147/344 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1548
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2218
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm48501
Panther	1	1.100	-	-	O	PTHR22624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100