Protein Alignment Atg4b and atg4c

DIOPT Version :9

• Sequence 1: NP_650452.1
• Gene: Atg4b / 41868
• FlyBaseID: FBgn0038325
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_001002103.1
• Gene: atg4c / 415193
• ZFINID: ZDB-GENE-040625-84
• Length: 463
• Species: Danio rerio
• Alignment Length: 592
• Identity: 190/592 - (32%)
• Similarity: 274/592 - (46%)
• Gaps: 197/592 - (33%)

  Fly   143 TKG------MESKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESSITELP 201
            |||      ::||.::.||:|||.|:.|.: |:||:..||:|||:|||.:...
Zfish     3 TKGTDEVETLKSKFMSAWHSVKYSWALKSK-TAFSRNSPVFLLGKCYHFKVVD------------ 54

  Fly   202 SGADTTPDNATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEGIEGF 266
               |..|..:|:                    :.:|:         |.|...|.|         |
Zfish    55 ---DENPTESTA--------------------EALDD---------DVVTGNVDE---------F 78

  Fly   267 RRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRY--------- 322
            |:||.||:|:|||.|||.:.||::||||||||.||:|||:.||.|:.|.|||.|::
Zfish    79 RKDFTSRVWLTYREEFPALPGSSFTSDCGWGCTLRAGQMILAQALLLHILGRDWKWSEALSLEPL 143

  Fly   323 ----------------------------------------DSESQLHSTYEDNMHKKIVKWFGDS 347
                                                    :::|.|..||    |:.||.||||
Zfish   144 DTETWTSSAARRLVATLEASIQGERAQASQPLCPVQGEAEEADSYLKETY----HRTIVSWFGD- 203

  Fly   348 SSKSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFDNISVYVAKDCTIYL 412
             ..|:...|:.||.||...||:.|||||||.|:::|:.|::.|.  :|....|.||||:|||:|.
Zfish   204 -GPSAQLGIYKLVELGMTSGKQAGDWYGPAVVAHILRKAVDEAV--DAMLKGIRVYVAQDCTVYS 265

  Fly   413 QDIEDQCSIPEPAPKPHVPWQQAKRPQAETTKTEQQQ-----------HWKSLIVLIPLRLGSDK 466
            .|:.|                      :.:|:||...           ..:::::|||:|||.:|
Zfish   266 ADVID----------------------SHSTRTESHSDPQGLDSGASPDSRAVVILIPVRLGGEK 308

  Fly   467 LNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENFSLHSFH 531
            :||.|.:.:|.:||.|:|:||:|||||.:.||||||:|.||::||||||..|||:..:|.|.|||
Zfish   309 INPEYLNFVKSILSLEYCIGIIGGKPKQAYYFVGFQDDSLIYMDPHYCQSFVDVSTSDFPLQSFH 373

  Fly   532 CKSPRKLKASKMDPSCCIGFYCATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSH 596
            |.||:|:..|||||||.||||..:...|:.....:...|.|
Zfish   374 CPSPKKMSFSKMDPSCTIGFYSKSVEHFEKIANELSKILQP------------------------ 414

  Fly   597 QTEQTEMNYPLFSFSRGRCMDHERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQDDSE 661
               .::..||.|:..:|...|:|.....:....|.|:.    |::.|                :.
Zfish   415 ---SSKEKYPAFTIMKGHGKDYELSIAVEKREWPFIRD----ARKAG----------------TT 456

  Fly   662 SEEFVLL 668
            |.:||||
Zfish   457 SGDFVLL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	142/360 (39%)
atg4c	NP_001002103.1	Peptidase_C54	76..407	CDD:281417	143/369 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581282
Domainoid	1	1.000	282	1.000	Domainoid score	I1615
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2444
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm25992
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	1	1.100	-	-	O	PTHR22624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790