Protein Alignment Atg4b and atg-4.2

DIOPT Version :10

• Sequence 1: NP_650452.1
• Gene: Atg4b / 41868
• FlyBaseID: FBgn0038325
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_502208.1
• Gene: atg-4.2 / 3565022
• WormBaseID: WBGene00014080
• Length: 521
• Species: Caenorhabditis elegans
• Alignment Length: 683
• Identity: 171/683 - (25%)
• Similarity: 266/683 - (38%)
• Gaps: 227/683 - (33%)

  Fly    26 IVEGSRI----CGQDADPLSLPLVEDGAIEEE----QAAPIQTI----HRTVFAVPRVPSPSPVS 78
            |...||:    |..::.     |.:|...|.|    ..||.:.:    .|.|.....|...:|.|
 Worm    11 IASSSRLPRKYCSSESS-----LSDDDGHEIEHVLKHGAPEEALTPDTERMVVLGQDVVQSAPAS 70

  Fly    79 -TSGANLNLKTE-NAATATPQRKISTSSRFMNAFSQLYGGGNSGPSCGHVEQHNEEPGDLSANRT 141
             ..|.||:..:: .:|.|:....|..||...:..           |.|.:|:|::
 Worm    71 LVPGGNLSWMSKIKSAGASMMGSIRPSSSSQDVH-----------STGEIEKHSK---------- 114

  Fly   142 PTKGMESKLVAMWHNVKYG--WSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESSITELPSGA 204
              |..:::|.:.|:|:||.  |... |...:..|..|..|||.|
 Worm   115 --KKWKARLWSTWNNIKYSSTWMSD-RSDEYGGENDVVFLGRRY--------------------- 155

  Fly   205 DTTPDNATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEGIEGFRRD 269
                               |||                           |.|.....|.|.|..|
 Worm   156 -------------------STS---------------------------VDESGLRSGFENFCSD 174

  Fly   270 FYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYD----SESQLHS 330
            :|||:|:|||.:||.:..::.|:|||||||:|:.||:.||.::.:..||.||:.    |....|.
 Worm   175 YYSRLWITYRTDFPALLDTDTTTDCGWGCMIRTTQMMVAQAIMVNRFGRDWRFTRRKRSHVAAHG 239

  Fly   331 TYEDNMHKKIVKW-----FGDSSSKSSPFSIHALV---RLGEHLGKKP-GDWYGPASVSYLLKHA 386
            ..:|...:||.:|     |.|  ..::|..||.:|   .:|:  |||. |.||.|:...:::|.|
 Worm   240 DEDDFDREKIQEWMILKLFED--KPTAPLGIHKMVGIAAMGK--GKKAVGSWYSPSEAVFIMKKA 300

  Fly   387 LEHAAQENADFDNISVYVAKDCTIYLQDIEDQCSIPEPAPKPHVPWQQAKRPQAETTKTEQQQHW 451
            |..::....  .|.::.::.|..::::|||                       .||      ::|
 Worm   301 LTESSSPLT--GNTAMLLSIDGRVHIRDIE-----------------------VET------KNW 334

  Fly   452 -KSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQ 515
             |.||::|.:|||:.:|||:|...|..|.:.|.||||.||:|.||.:|||:..|::|:||||...
 Worm   335 MKKLILVIVVRLGAAELNPIYVPHLMRLFAMESCLGITGGRPDHSSWFVGYYGDQIIYLDPHVAH 399

  Fly   516 EM--VDVNQENFSL------------HSFHCKSPRKLKASKMDPSCCIGFYCATKSDFDNFMESV 566
            |.  :|:|.....:            .|:||:...|:....|||||.:.|...::..|||.|..:
 Worm   400 EYIPIDINPNTNVVDSDSKKAKKCPEKSYHCRLLSKMHFFDMDPSCALCFQFESREQFDNDMRQL 464

  Fly   567 QLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMNYPLFSFSRGRCMDHERDEMSDSLYKPL 631
            .|         ...:|...|..|.                         |...||.|...:|
 Worm   465 NL---------SQFIDIDQGEEHG-------------------------MKRVRDPMFSVVY--- 492

  Fly   632 IKQVASLAQELGAQLAPPQHGDEHDQDDSESEE 664
                       |.:..||    .::::.||:|:
 Worm   493 -----------GERRQPP----SYEREVSETEQ 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	263..565	CDD:460915	109/329 (33%)
atg-4.2	NP_502208.1	Peptidase_C54	168..463	CDD:460915	109/329 (33%)