DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg4b and Atg4b

DIOPT Version :9

Sequence 1:	NP_650452.1	Gene:	Atg4b / 41868	FlyBaseID:	FBgn0038325	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	XP_006245595.1	Gene:	Atg4b / 316640	RGDID:	1309664	Length:	393	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	125/403 - (31%)
Similarity:	185/403 - (45%)	Gaps:	98/403 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QPVWLLGRCYHRRFTPPVSMESSITELPSGADTTPDNATSAFDSIQATSTSTSLYPALNPQQIDE 238
            :|||:|||.|           |..||.                                    ||
  Rat    24 EPVWILGRKY-----------SIFTEK------------------------------------DE 41

  Fly   239 IVVPQELGMDAVENQVGEQPWEEGIEGFRRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSG 303
            |:                           .|..||:|.||||.||.:.|:..|||.|||||||.|
  Rat    42 IL---------------------------SDVASRLWFTYRRNFPAIGGTGPTSDTGWGCMLRCG 79

  Fly   304 QMLFAQGLICHFLGRSWRYDSESQLHSTYEDNMHKKIVKWFGDSSSKSSPFSIHALVRLGEHLGK 368
            ||:|||.|:|..|||.||:....:...:|     ..::..|.|  .|.|.:|||.:.::|...||
  Rat    80 QMIFAQALVCRHLGRDWRWTQRKRQPDSY-----FSVLNAFLD--RKDSYYSIHQIAQMGVGEGK 137

  Fly   369 KPGDWYGPASVSYLLKHALEHAAQENADFD---NISVYVAKDCTIYLQDIEDQCSIPEPAPKPHV 430
            ..|.||||.:|:.:||        :.|.||   :::|::|.|.|:.:::|...|....|......
  Rat   138 SIGQWYGPNTVAQVLK--------KLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRASLPCAGAAA 194

  Fly   431 PWQQAKRP----QAETTKTEQQQHWKSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGK 491
            ...:::|.    .|....|.:...|:.|::|||||||...:|..|...||........||::|||
  Rat   195 LSMESERHCNGLPAGAEVTNRPLAWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGK 259

  Fly   492 PKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENF-SLHSFHCKSPR-KLKASKMDPSCCIGFYCA 554
            |..:.||:|:..:.||:||||..|..|::....| ...||||:.|. ::...::|||..:||:|.
  Rat   260 PNSAHYFIGYVGEELIYLDPHTTQPAVELTDSCFIPDESFHCQHPPCRMGIGELDPSIAVGFFCK 324

  Fly   555 TKSDFDNFMESVQ 567
            |:.||:::.:.|:
  Rat   325 TEEDFNDWCQQVK 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	111/309 (36%)
Atg4b	XP_006245595.1	Peptidase_C54	40..335	CDD:281417	85/301 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720