DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg4b and ATG4B

DIOPT Version :9

Sequence 1:	NP_650452.1	Gene:	Atg4b / 41868	FlyBaseID:	FBgn0038325	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	XP_016859126.1	Gene:	ATG4B / 23192	HGNCID:	20790	Length:	479	Species:	Homo sapiens

Alignment Length:	445	Identity:	133/445 - (29%)
Similarity:	206/445 - (46%)	Gaps:	81/445 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 MWHNVKYGWSGKMRQTSF----SKEQPVWLLGRCYHRRFTPPVSMESSITELPSGADTTPDNATS 213
            :|.....||.|.....::    .:..|::|:     .|:.|         .|..|.||.   ||.
Human     8 LWQPETSGWRGPCPGLAWVQARRRRYPIYLV-----HRWAP---------GLHYGTDTM---ATM 55

  Fly   214 AFDSIQATS--TSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEG--------IEGFRR 268
            ...|....|  .:|..|..|...:.::.            .:..|..|..|        .:....
Human    56 TVCSAPGGSGCVATLTYDTLRFAEFEDF------------PETSEPVWILGRKYSIFTEKDEILS 108

  Fly   269 DFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYDSESQLHSTYE 333
            |..||:|.|||:.||.:.|:..|||.|||||||.|||:|||.|:|..|||.||:....:...:|.
Human   109 DVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYF 173

  Fly   334 DNMHKKIVKWFGDSSSKSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFD 398
            ..::..|       ..|.|.:|||.:.::|...||..|.||||.:|:.:||        :.|.||
Human   174 SVLNAFI-------DRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLK--------KLAVFD 223

  Fly   399 ---NISVYVAKDCTIYLQDIEDQCSIPEPAPKPHVPWQQAKRPQAETTK-----------TEQQQ 449
               :::|::|.|.|:.:::|...|       :..||...|....|::.:           |.:..
Human   224 TWSSLAVHIAMDNTVVMEEIRRLC-------RTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPS 281

  Fly   450 HWKSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYC 514
            .|:.|::|||||||...:|..|...||........||::||||..:.||:|:..:.||:||||..
Human   282 PWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTT 346

  Fly   515 QEMVDVNQENF-SLHSFHCKSPR-KLKASKMDPSCCIGFYCATKSDFDNFMESVQ 567
            |..|:.....| ...||||:.|. ::..:::|||..:||:|.|:.||:::.:.|:
Human   347 QPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVK 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	110/316 (35%)
ATG4B	XP_016859126.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750