Protein Alignment Atg4b and ATG4A

DIOPT Version :9

• Sequence 1: NP_650452.1
• Gene: Atg4b / 41868
• FlyBaseID: FBgn0038325
• Length: 668
• Species: Drosophila melanogaster
• Sequence 2: NP_443168.2
• Gene: ATG4A / 115201
• HGNCID: 16489
• Length: 398
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 118/313 - (37%)
• Similarity: 178/313 - (56%)
• Gaps: 36/313 - (11%)

  Fly   269 DFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYDSESQLHSTYE 333
            |..:|:|.||||:|..:.|:..:||.|||||||.|||:.||.|||..|||.|.::.:.:....|:
Human    48 DISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQ 112

  Fly   334 DNMHKKIVKWFGDSSSKSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFD 398
                 :|::.|.|  .|...:|||.:.::|...||..|:|:||.:|:.:||        :.|.||
Human   113 -----RILQCFLD--RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLK--------KLALFD 162

  Fly   399 ---NISVYVAKDCTIYLQDIEDQCSI-PEPAPKPHVPWQQAKRPQAETTKTEQQQ-------HWK 452
               :::|||:.|.|:.::||:..|.: |..|.      ....||....|.:.|.:       .||
Human   163 EWNSLAVYVSMDNTVVIEDIKKMCRVLPLSAD------TAGDRPPDSLTASNQSKGTSAYCSAWK 221

  Fly   453 SLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEM 517
            .|::::|||||.:::||||....|........||.|||||.::.||:||..|.||.||||..|..
Human   222 PLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTF 286

  Fly   518 VDVNQENFSLH--SFHC-KSPRKLKASKMDPSCCIGFYCATKSDFDNFMESVQ 567
            || .:||.:::  :||| :||:::....:|||..:||:|..:.||||:...||
Human   287 VD-TEENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQ 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	116/309 (38%)
ATG4A	NP_443168.2	Peptidase_C54	42..335	CDD:367485	116/308 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750