DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg4b and ccser2

DIOPT Version :9

Sequence 1:	NP_650452.1	Gene:	Atg4b / 41868	FlyBaseID:	FBgn0038325	Length:	668	Species:	Drosophila melanogaster
Sequence 2:	XP_012822284.2	Gene:	ccser2 / 100379972	XenbaseID:	XB-GENE-5737386	Length:	1102	Species:	Xenopus tropicalis

Alignment Length:	576	Identity:	101/576 - (17%)
Similarity:	186/576 - (32%)	Gaps:	210/576 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KLTDEKLMLFEAAGEGTIVEGS--RICGQDADPLSLPLVEDGAIEEEQAAPIQTIHRTVFAVPRV 71
            |:.|::....:.|.|.   :||  |:..::....::.:.....:.|.                .:
Frog    87 KVNDKRFSQSQTAAEN---DGSRFRVTAKNLKQSNMLVTRKQDLNEN----------------HL 132

  Fly    72 PSPSPVSTSGANLNLKTENAATATPQRKISTSSRFMNAFSQLYGGGNSGPSCGHVEQHNEEPGDL 136
            |.|       .|....|:|    .||...:..|.|....||:.|..::.|..|.:...
Frog   133 PGP-------PNSGRLTKN----HPQFGRTIFSSFNALKSQVNGYYSNKPPTGLMRPR------- 179

  Fly   137 SANRTPTKGMESKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRF-------------- 187
             ||...|:...:.:||...:.|..:|...|..|||...|..||...:..|.
Frog   180 -ANSATTRNFSNNIVAQSADSKKPYSSVRRSQSFSDSIPNSLLPSTHMTRSHSFSREVDLSGPFE 243

  Fly   188 TPPVSMESSIT-----------ELPSGADT------TPDNATSAFDSIQATSTST---SLYPALN 232
            |..|.:.:|:.           |||:|:::      |...:......::.||.|.   .:.|:..
Frog   244 THQVPVRTSLKPALLSRTARHYELPNGSESQIKYGFTRTCSVGPASGLRKTSLSNGSDQIVPSGY 308

  Fly   233 PQQIDEIVVP--QELGMDAV--------------EN------QVGE---QPWEEGIEGFRRDFYS 272
            .:....::.|  ..|.||.:              ||      :.||   :..|..::|
Frog   309 KRTRPSLLKPNRSHLAMDLITDSTKMSSHISSVTENTGTGPSRTGESTDEQHENKLKG------- 366

  Fly   273 RIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYDSE----------SQ 327
                   |:|.|   .||                    ::|..|.::...||.          |.
Frog   367 -------RDFVI---DNY--------------------VLCDNLEKTDSKDSYFGDDIDELSISS 401

  Fly   328 LHSTYEDNMHKKIVKWFGD--SSSKSSPFSIHALVRLG--------EHLGKKPGDWYG------- 375
            |.|:.::::.:.....|.|  ..:|:|..|...|::..        |...:|..||.|
Frog   402 LSSSEKNDLTEDFSDEFIDLEEGNKTSVDSEKDLIKKSSAELPENKESNFRKTDDWIGMNITVSP 466

  Fly   376 --------------PASV----------SYLL-KHALE-----H--AAQENADFDNISVYVAKD- 407
                          |:|:          :|:. :..:|     |  .:.|:::.:::.:....|
Frog   467 YKEKRISPDMGYRDPSSLELSPSDSSGGTYMWDEEGMEPIGNIHPCGSYESSEMNSLDILNNLDS 531

  Fly   408 CTIYLQDIEDQCSIPEPAP--------KPHVPWQQAKRPQAETTKTEQQQHWKSLI 455
            |.:...|:.....:||..|        ..|  :::|:|    :.:..||..||..:
Frog   532 CDLEDDDLMLDVDLPEDTPFDIGKVENMSH--FERAER----SLRQPQQAFWKRAV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4b	NP_650452.1	Peptidase_C54	264..565	CDD:281417	43/260 (17%)
ccser2	XP_012822284.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860