DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5038 and TMTC4

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001337500.1 Gene:TMTC4 / 84899 HGNCID:25904 Length:818 Species:Homo sapiens


Alignment Length:810 Identity:275/810 - (33%)
Similarity:425/810 - (52%) Gaps:127/810 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DLVH---KATLHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTH 64
            ||.|   .:.|.....:.::..:.::|:...  ....|||||:.|||.|:|:.: .|....::.|
Human    26 DLDHILPSSVLPPFWAKLVVGSVAIVCFARS--YDGDFVFDDSEAIVNNKDLQA-ETPLGDLWHH 87

  Fly    65 DFWGASLLSSDSHKSFRPLTTLMFHCEYALL-GLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPE 128
            ||||:.|.|:.||||:||||.|.|...|.|. |........:|:|||...::||..:...|:...
Human    88 DFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGL 152

  Fly   129 VSTA---------RWAILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLL---LTVANTGRL 181
            ..|:         |.::|:|.|||.||:|||.|:||||||:|:..:..||..|   .....:.:.
Human   153 QYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKE 217

  Fly   182 GPQTGGLIMLLT----AVGMLFKESAVTIPMSCVLLDY-------------------FQNGYYHL 223
            |..:....:||:    ||.||.||..:|: :||.|::.                   ||:...||
Human   218 GAHSSTFWVLLSIFLGAVAMLCKEQGITV-LSCKLIEVAVLHTTALPGKGLLSSMCGFQSHPVHL 281

  Fly   224 ---------------RFKDQWSLLRTRISYLFYLL------------------------------ 243
                           :|.:|.|  :..::.:|.:|                              
Human   282 HSSQLEGETKWECVPKFYNQTS--KMGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNG 344

  Fly   244 -----------GTLGLLTARLWWQDFET--PTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLML 295
                       |..|:|..|  |:...|  |.|.|||||.:..:.:|.|.::..|...:|.||:|
Human   345 GLLFRMTLLTSGGAGMLYVR--WRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLL 407

  Fly   296 CPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALM---------NFRRLPGMMLALGLMI 351
            ||.|||:||::||:.|:.:|.|.|:..:...: ..|:.|:         :.||:  :.|.||.::
Human   408 CPWWLCFDWSMGCIPLIKSISDWRVIALAALW-FCLIGLICQALCSEDGHKRRI--LTLGLGFLV 469

  Fly   352 VPFLPASGIIC-VGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLFSVM 415
            :||||||.:.. ||||:|||.||:||:|:|:|..:||    .:.:::|..:..:..:::.:..:.
Human   470 IPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGF----GALSKHTKKKKLIAAVVLGILFIN 530

  Fly   416 MVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESA 480
            .:|...|:.:|.:|||||:|||.|||.||||||||.:...|.||.|.|.::|..|:.|.|.|..|
Human   531 TLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHA 595

  Fly   481 LMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANF 545
            :.||||:.:|..:|..|||.:.||:|..|.|.||||||||||::..:::.|..||..|:|:|..:
Human   596 MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKY 660

  Fly   546 AVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRISNQALQHL 610
            ..||||:|.||.:..|:.:||:.|::|..|.|....||.|::.:|||.|....|..:..:||:.:
Human   661 PDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELI 725

  Fly   611 PNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAI 675
            |||.|::|..||||||.:.|.|:||::.:.|:..|:...||.||.||||||.....|.:.|..::
Human   726 PNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISL 790

  Fly   676 SISAARATTARENLSKLLKRLEREAQVMQR 705
            .:... |:..:||...|.::||    :||:
Human   791 QLDPT-ASGTKENYGLLRRKLE----LMQK 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594 28/74 (38%)
TPR 442..701 CDD:223533 108/258 (42%)
TPR_1 444..477 CDD:278916 16/32 (50%)
TPR repeat 444..472 CDD:276809 14/27 (52%)
TPR_17 466..499 CDD:290167 13/32 (41%)
TPR repeat 480..506 CDD:276809 12/25 (48%)
TPR repeat 511..541 CDD:276809 15/29 (52%)
TPR_1 512..545 CDD:278916 16/32 (50%)
TPR_1 546..577 CDD:278916 13/30 (43%)
TPR repeat 546..574 CDD:276809 12/27 (44%)
TPR repeat 580..608 CDD:276809 9/27 (33%)
TPR repeat 614..642 CDD:276809 12/27 (44%)
TPR repeat 647..677 CDD:276809 12/29 (41%)
TMTC4NP_001337500.1 DUF1736 369..443 CDD:369859 28/74 (38%)
TPR 558..794 CDD:223533 102/235 (43%)
TPR repeat 559..587 CDD:276809 14/27 (52%)
TPR repeat 592..622 CDD:276809 13/29 (45%)
TPR repeat 627..655 CDD:276809 14/27 (52%)
TPR repeat 661..687 CDD:276809 11/25 (44%)
TPR repeat 695..723 CDD:276809 9/27 (33%)
TPR repeat 728..758 CDD:276809 14/29 (48%)
TPR repeat 763..791 CDD:276809 12/27 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 73 1.000 Domainoid score I9290
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32796
Inparanoid 1 1.050 447 1.000 Inparanoid score I1635
Isobase 1 0.950 - 0 Normalized mean entropy S3833
OMA 1 1.010 - - QHG52291
OrthoDB 1 1.010 - - D1320023at2759
OrthoFinder 1 1.000 - - FOG0006261
OrthoInspector 1 1.000 - - oto90298
orthoMCL 1 0.900 - - OOG6_105345
Panther 1 1.100 - - LDO PTHR44227
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2852
SonicParanoid 1 1.000 - - X4542
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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