DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5038 and bbs4

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001070934.2 Gene:bbs4 / 768303 ZFINID:ZDB-GENE-060126-2 Length:528 Species:Danio rerio


Alignment Length:327 Identity:76/327 - (23%)
Similarity:138/327 - (42%) Gaps:68/327 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 SIGFCLLSIYGFLYWYDSSTENTHWRTALR-----ILLMLLFSVMMVR-TRQRATDWLNEEQLFK 434
            ::|.|      ::|..|..:.......||:     :..|:|..:.::: ..::|.|      ::|
Zfish   140 NLGVC------YIYTKDFRSAEEQLNLALQLNKHDLTYMMLGKIHLLQGDTEKAID------VYK 192

  Fly   435 SALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEE 499
            ||::..|:|.::...:..|...:|...|||:|...|:...||...|::..|::.:.||....|..
Zfish   193 SAVEFSPENTELLTTLGLLYMQLGKYQKAFEHLGNALTYDPNNFKAILAAGSMMQTHGDYDVAMN 257

  Fly   500 YIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCY-----YNMGNLYLEQ 559
            ..|:|..|.|..|..|.|:|:....:.||..|::    .|| |||:...:     ||:|.::|..
Zfish   258 KYRVAAYAVPESPPLWNNIGMCFFGKKKYVAAIS----CLK-RANYLSPFDWKILYNLGLVHLTM 317

  Fly   560 KRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRISNQALQHLPNDVSILFIRANVL 624
            :::|.|.|....|:.|.||..:.:..:...|.|   .|||                         
Zfish   318 QQFASAFHFLSAAINLRPRMSELYMLLAVALTN---LDDA------------------------- 354

  Fly   625 GKLKHYTEAEAIYKRVIELEPHNTLYHTNLGV-LYHRWDKTQEAIEAYRTAISISAARATTAREN 688
                  ..|...|::.::::..:.|.:.|..| ||::.|| :.|:..|:.    ...:..|..||
Zfish   355 ------ENARRSYEQAVQIDESSPLVNLNFAVFLYNQGDK-KAALLQYQE----MERKVNTQLEN 408

  Fly   689 LS 690
            .|
Zfish   409 SS 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594
TPR 442..701 CDD:223533 62/255 (24%)
TPR_1 444..477 CDD:278916 8/32 (25%)
TPR repeat 444..472 CDD:276809 7/27 (26%)
TPR_17 466..499 CDD:290167 9/32 (28%)
TPR repeat 480..506 CDD:276809 7/25 (28%)
TPR repeat 511..541 CDD:276809 8/29 (28%)
TPR_1 512..545 CDD:278916 11/32 (34%)
TPR_1 546..577 CDD:278916 9/35 (26%)
TPR repeat 546..574 CDD:276809 8/32 (25%)
TPR repeat 580..608 CDD:276809 5/27 (19%)
TPR repeat 614..642 CDD:276809 2/27 (7%)
TPR repeat 647..677 CDD:276809 9/30 (30%)
bbs4NP_001070934.2 TPR repeat 68..95 CDD:276809
TPR_11 100..166 CDD:290150 6/31 (19%)
TPR repeat 104..129 CDD:276809
TPR repeat 134..164 CDD:276809 6/29 (21%)
TPR_11 169..233 CDD:290150 16/69 (23%)
TPR repeat 169..196 CDD:276809 7/32 (22%)
TPR repeat 202..229 CDD:276809 6/26 (23%)
TPR_11 235..301 CDD:290150 21/70 (30%)
TPR repeat 237..264 CDD:276809 7/26 (27%)
TPR repeat 270..298 CDD:276809 11/32 (34%)
PH-like <272..340 CDD:302622 22/72 (31%)
TPR_11 272..335 CDD:290150 20/67 (30%)
TPR repeat 303..333 CDD:276809 8/29 (28%)
TPR_11 305..369 CDD:290150 18/97 (19%)
TPR repeat 338..366 CDD:276809 7/61 (11%)
TPR repeat 372..397 CDD:276809 9/25 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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