DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5038 and KDM6A

DIOPT Version :9

Sequence 1:NP_650451.1 Gene:CG5038 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster
Sequence 2:XP_011542260.1 Gene:KDM6A / 7403 HGNCID:12637 Length:1489 Species:Homo sapiens


Alignment Length:311 Identity:69/311 - (22%)
Similarity:116/311 - (37%) Gaps:73/311 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   355 LPASGIICVGFVIAERTLYVPSIGFCLLSIYGFL----------YWYDSSTENTHWRTALRILLM 409
            |....:.|...:|.:....|.|..||.|..:..|          |....|.::.:|:.|     .
Human    72 LLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNA-----A 131

  Fly   410 LLFSVMMVRTRQRATDWLNEEQLFKSALQVCPD--NAK-VHYNIA---RLATDMGNNTKAFQ--- 465
            .|:.:.:|.....|..|  ..:.|:..|.|.|.  .|| :|..:.   ::.||..::.|.||   
Human   132 FLYGLGLVYFHYNAFQW--AIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLAL 194

  Fly   466 -------------------------HYHRAIELYPNY-----------ESALMNLGNLYREH--- 491
                                     .||.|.|.|...           .:.|..||  :..|   
Human   195 VDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLG--WMHHTVD 257

  Fly   492 --GQLSTAE----EYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYY 550
              |..:|.|    :|::.:|:|.|....:|..||...|:.||...|..||.:::......|..:.
Human   258 LLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWC 322

  Fly   551 NMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALR 601
            ::|.||.:|.:..:||..:..||.|:.....||.::.|:.::.....||::
Human   323 SIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIK 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5038NP_650451.1 DUF1736 258..331 CDD:285594
TPR 442..701 CDD:223533 48/214 (22%)
TPR_1 444..477 CDD:278916 13/64 (20%)
TPR repeat 444..472 CDD:276809 11/59 (19%)
TPR_17 466..499 CDD:290167 12/52 (23%)
TPR repeat 480..506 CDD:276809 8/34 (24%)
TPR repeat 511..541 CDD:276809 9/29 (31%)
TPR_1 512..545 CDD:278916 9/32 (28%)
TPR_1 546..577 CDD:278916 10/30 (33%)
TPR repeat 546..574 CDD:276809 8/27 (30%)
TPR repeat 580..608 CDD:276809 5/22 (23%)
TPR repeat 614..642 CDD:276809
TPR repeat 647..677 CDD:276809
KDM6AXP_011542260.1 TPR repeat 93..121 CDD:276809 6/27 (22%)
TPR 106..399 CDD:223533 60/277 (22%)
TPR repeat 129..159 CDD:276809 7/36 (19%)
TPR_1 130..163 CDD:278916 9/39 (23%)
TPR repeat 164..194 CDD:276809 8/29 (28%)
TPR repeat 205..233 CDD:276809 5/27 (19%)
TPR repeat 243..278 CDD:276809 8/36 (22%)
TPR_17 272..303 CDD:290167 10/30 (33%)
TPR repeat 285..312 CDD:276809 9/26 (35%)
TPR repeat 317..347 CDD:276809 9/29 (31%)
TPR_1 318..351 CDD:278916 10/32 (31%)
TPR repeat 352..378 CDD:276809 5/22 (23%)
JmjC 1151..1215 CDD:214721
JmjC 1185..1293 CDD:202224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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