Protein Alignment Tmtc4 and Tmtc4

DIOPT Version :10

• Sequence 1: NP_650451.1
• Gene: Tmtc4 / 41867
• FlyBaseID: FBgn0038324
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_082927.1
• Gene: Tmtc4 / 70551
• MGIID: 1921050
• Length: 741
• Species: Mus musculus
• Alignment Length: 749
• Identity: 269/749 - (35%)
• Similarity: 403/749 - (53%)
• Gaps: 73/749 - (9%)

  Fly     2 LDLVHKATLHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDF 66
            ||.:..:.|.....:.::..:.|||:...  ....|||||:.|||.|:|:.| .|....::.|||
Mouse     8 LDHIVPSVLPPFWAKLVVGFVSLLCFARS--YDGDFVFDDSEAIVNNKDLQS-DTPLGDLWHHDF 69

  Fly    67 WGASLLSSDSHKSFRPLTTLMFHCEYALL-GLSAAHMKFLNLLLHCVNTLLMWRLIRSLY----- 125
            ||:.|.|:.||||:||||.|.|...|.|. |........:|:|||...::||..:...|:
Mouse    70 WGSKLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHGSISILMLDVFSVLFGGLQY 134

  Fly   126 ---------VPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRL 181
                     .|..|     :|:..|||.||:|||.|:||||||:|:..:..||..|.........
Mouse   135 TGKGQRVHLAPRAS-----LLATLLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCQAFKET 194

  Fly   182 GPQTGG--------LIMLLTAVGMLFKESAVTIPMSCVLLDYFQNGYYHL--------------- 223
            |.:.|.        |.:.|.||.||.||..:|:.....:.|....|...:
Mouse   195 GNKEGTHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKLDILAAVRKVLHKDKSQE 259

  Fly   224 ---RFKDQWSLLRTRISYLFYLLGTLGLLTARLWWQDFET--PTFKEVDNPVAHNEHVLTRGLSQ 283
               .||:...|.|..:    ..:|...:|..|  |:...|  |.|.|||||.:..:.:|.|.::.
Mouse   260 NAGMFKNGGLLFRIAL----LTIGGTSMLYIR--WKIMGTGPPAFTEVDNPASFADSMLVRAINY 318

  Fly   284 QYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALMNFRRLPG------ 342
            .|...:|.||:|||.|||:||::||:.|:.::.|.|:..:...: :.|:.|: |:.|..
Mouse   319 NYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALW-LCLIGLI-FQALCSEDSCKR 381

  Fly   343 --MMLALGLMIVPFLPASGIIC-VGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTAL 404
              :.|.||.:::||||||.:.. ||||:|||.||:||.|:|:|..:||    .:.:.:|..:..:
Mouse   382 RILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCVLLTFGF----GALSRHTKKKKPV 442

  Fly   405 RILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHR 469
            ..:::.:..:..:|...|:.:|.:|||||:|||.|||.||||||||.:...|.||.|.|.::|..
Mouse   443 AAIILGILLINALRCVIRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYRE 507

  Fly   470 AIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALAS 534
            |:.|.|.|..|:.||||:.:|..:|..|||.:.||:|..|.|.||||||||||::..::::|..|
Mouse   508 AVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQS 572

  Fly   535 YEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDA 599
            |..|:|:|..:..||||:|.||.:..|:.:||:.|::|..|.|....||.|::.:|||.|....|
Mouse   573 YRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQA 637

  Fly   600 LRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKT 664
            ..:..:|||.:|||.|::|..||||||.:.|.|:||::.:.|:..|:...||.||.||||||...
Mouse   638 EAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHL 702

  Fly   665 QEAIEAYRTAISISAARATTARENLSKLLKRLER 698
            ..|.:.|..::.:... |...:||.|.|.::||:
Mouse   703 DSAKKHYEISLQLDPV-AVGTKENYSLLRRKLEQ 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc4	NP_650451.1	TMTC_DUF1736	258..331	CDD:462468	27/74 (36%)
		LapB	431..675	CDD:442196	112/243 (46%)
		TPR repeat	444..472	CDD:276809	14/27 (52%)
		TPR repeat	480..506	CDD:276809	12/25 (48%)
		TPR repeat	511..541	CDD:276809	15/29 (52%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	9/27 (33%)
		TPR repeat	614..642	CDD:276809	12/27 (44%)
		TPR repeat	647..677	CDD:276809	12/29 (41%)
Tmtc4	NP_082927.1	TMTC_DUF1736	292..366	CDD:462468	29/81 (36%)
		TPR	475..681	CDD:440225	89/205 (43%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	482..515		14/32 (44%)
		TPR repeat	482..510	CDD:276809	11/27 (41%)
		TPR repeat	515..545	CDD:276809	15/29 (52%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	516..549		16/32 (50%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	550..583		13/32 (41%)
		TPR repeat	550..578	CDD:276809	11/27 (41%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	584..617		11/32 (34%)
		TPR repeat	584..610	CDD:276809	8/25 (32%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	618..651		15/32 (47%)
		TPR repeat	618..646	CDD:276809	14/27 (52%)
		TPR	645..>738	CDD:440225	21/60 (35%)
		TPR repeat	651..681	CDD:276809	13/29 (45%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	652..685		12/32 (38%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	686..719		7/19 (37%)
		TPR repeat	686..714	CDD:276809	7/19 (37%)