DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and Tmtc4

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001347527.1	Gene:	Tmtc4 / 70551	MGIID:	1921050	Length:	741	Species:	Mus musculus

Alignment Length:	749	Identity:	269/749 - (35%)
Similarity:	403/749 - (53%)	Gaps:	73/749 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDLVHKATLHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDF 66
            ||.:..:.|.....:.::..:.|||:...  ....|||||:.|||.|:|:.| .|....::.|||
Mouse     8 LDHIVPSVLPPFWAKLVVGFVSLLCFARS--YDGDFVFDDSEAIVNNKDLQS-DTPLGDLWHHDF 69

  Fly    67 WGASLLSSDSHKSFRPLTTLMFHCEYALL-GLSAAHMKFLNLLLHCVNTLLMWRLIRSLY----- 125
            ||:.|.|:.||||:||||.|.|...|.|. |........:|:|||...::||..:...|:
Mouse    70 WGSKLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHGSISILMLDVFSVLFGGLQY 134

  Fly   126 ---------VPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRL 181
                     .|..|     :|:..|||.||:|||.|:||||||:|:..:..||..|.........
Mouse   135 TGKGQRVHLAPRAS-----LLATLLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCQAFKET 194

  Fly   182 GPQTGG--------LIMLLTAVGMLFKESAVTIPMSCVLLDYFQNGYYHL--------------- 223
            |.:.|.        |.:.|.||.||.||..:|:.....:.|....|...:
Mouse   195 GNKEGTHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKLDILAAVRKVLHKDKSQE 259

  Fly   224 ---RFKDQWSLLRTRISYLFYLLGTLGLLTARLWWQDFET--PTFKEVDNPVAHNEHVLTRGLSQ 283
               .||:...|.|..:    ..:|...:|..|  |:...|  |.|.|||||.:..:.:|.|.::.
Mouse   260 NAGMFKNGGLLFRIAL----LTIGGTSMLYIR--WKIMGTGPPAFTEVDNPASFADSMLVRAINY 318

  Fly   284 QYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLVALMNFRRLPG------ 342
            .|...:|.||:|||.|||:||::||:.|:.::.|.|:..:...: :.|:.|: |:.|..
Mouse   319 NYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALW-LCLIGLI-FQALCSEDSCKR 381

  Fly   343 --MMLALGLMIVPFLPASGIIC-VGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTAL 404
              :.|.||.:::||||||.:.. ||||:|||.||:||.|:|:|..:||    .:.:.:|..:..:
Mouse   382 RILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCVLLTFGF----GALSRHTKKKKPV 442

  Fly   405 RILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHR 469
            ..:::.:..:..:|...|:.:|.:|||||:|||.|||.||||||||.:...|.||.|.|.::|..
Mouse   443 AAIILGILLINALRCVIRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYRE 507

  Fly   470 AIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALAS 534
            |:.|.|.|..|:.||||:.:|..:|..|||.:.||:|..|.|.||||||||||::..::::|..|
Mouse   508 AVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQS 572

  Fly   535 YEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDA 599
            |..|:|:|..:..||||:|.||.:..|:.:||:.|::|..|.|....||.|::.:|||.|....|
Mouse   573 YRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQA 637

  Fly   600 LRISNQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKT 664
            ..:..:|||.:|||.|::|..||||||.:.|.|:||::.:.|:..|:...||.||.||||||...
Mouse   638 EAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHL 702

  Fly   665 QEAIEAYRTAISISAARATTARENLSKLLKRLER 698
            ..|.:.|..::.:... |...:||.|.|.::||:
Mouse   703 DSAKKHYEISLQLDPV-AVGTKENYSLLRRKLEQ 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	27/74 (36%)
		TPR	442..701	CDD:223533	110/257 (43%)
		TPR_1	444..477	CDD:278916	16/32 (50%)
		TPR repeat	444..472	CDD:276809	14/27 (52%)
		TPR_17	466..499	CDD:290167	13/32 (41%)
		TPR repeat	480..506	CDD:276809	12/25 (48%)
		TPR repeat	511..541	CDD:276809	15/29 (52%)
		TPR_1	512..545	CDD:278916	16/32 (50%)
		TPR_1	546..577	CDD:278916	13/30 (43%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	9/27 (33%)
		TPR repeat	614..642	CDD:276809	12/27 (44%)
		TPR repeat	647..677	CDD:276809	12/29 (41%)
Tmtc4	NP_001347527.1	DUF1736	292..366	CDD:369859	27/74 (36%)
		TPR 1	448..481		14/32 (44%)
		TPR	481..717	CDD:223533	103/235 (44%)
		TPR 2	482..515		16/32 (50%)
		TPR repeat	482..510	CDD:276809	14/27 (52%)
		TPR repeat	515..545	CDD:276809	13/29 (45%)
		TPR 3	517..549		14/31 (45%)
		TPR 4	550..583		16/32 (50%)
		TPR repeat	550..578	CDD:276809	14/27 (52%)
		TPR 5	584..617		14/32 (44%)
		TPR repeat	584..610	CDD:276809	11/25 (44%)
		TPR repeat	618..646	CDD:276809	9/27 (33%)
		TPR 6	619..651		12/31 (39%)
		TPR repeat	651..681	CDD:276809	14/29 (48%)
		TPR 7	652..685		14/32 (44%)
		TPR 8	686..719		12/33 (36%)
		TPR repeat	686..714	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11796
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32796
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1602
Isobase	1	0.950	-	0	Normalized mean entropy	S3833
OMA	1	1.010	-	-		QHG52291
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0006261
OrthoInspector	1	1.000	-	-		oto93881
orthoMCL	1	0.900	-	-		OOG6_105345
Panther	1	1.100	-	-	LDO	PTHR44227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2852
SonicParanoid	1	1.000	-	-		X4542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820