DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and tmtc2a

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001124075.1	Gene:	tmtc2a / 564667	ZFINID:	ZDB-GENE-041210-299	Length:	844	Species:	Danio rerio

Alignment Length:	858	Identity:	244/858 - (28%)
Similarity:	378/858 - (44%)	Gaps:	196/858 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDS 76
            :||.|:.:|:.:      ....|.|.:||:.||..|:|:  || |.||.|...||||..|..|.|
Zfish     5 LVCSAVALLLYM------NTLSADFCYDDSRAIKTNQDL--LPDTPWTNILYDDFWGTLLTHSGS 61

  Fly    77 HKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAAL 141
            |||||||.|:.|...|.|.||........|:.|||..|.|.....|    |.:....|::|:..|
Zfish    62 HKSFRPLCTISFRLNYFLGGLDPYGFHLFNVGLHCCVTALFTAFCR----PLLGGGPWSLLAGLL 122

  Fly   142 FAAHPIHTEAVSGVVGRAELMFGMIHLLCLLL---------TVANTGRLGPQTGGLI---MLLTA 194
            ||:||||||||:||||||::......||.||.         ..|::.|:..:.|..:   :...|
Zfish   123 FASHPIHTEAVAGVVGRADVGAAFCFLLSLLCYSQYCRLRHNAAHSSRVAWRAGSWLAGSLGAAA 187

  Fly   195 VGMLFKESAVTIPMSCVLLDYFQNGYYHLRFKDQWSLL-----RTRISYLFYLLG-TLGLLTARL 253
            ..:|:||..||:.....:.|...  .:.||.:....:|     |:.:..|.:|:| .:.|||||.
Zfish   188 AALLWKEQGVTVLAVSAVYDVCV--VHRLRLRQALIVLLKRKNRSLLVSLAWLVGWGIILLTARF 250

  Fly   254 WWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDL 318
            .|...:.|.|...|||.|.:.|.|||.|:..||..:|.||:|||..|.:||::..|.|:.:|.|.
Zfish   251 HWMGNKPPNFSNSDNPAADSPHFLTRALTFLYLPSVNAWLLLCPDKLSFDWSMDAVPLLKSIADW 315

  Fly   319 R-LQGVIGFYSIVLVALMNFRR------------------------------------------- 339
            | ||.|:.:....|:|..:.|.
Zfish   316 RNLQSVMFYSGFALLAWFSLRNPPLQATKINESNGKSHVSNGKYATNGCSHKHNDNHYRDLNLKS 380

  Fly   340 --------------LPG----MMLALGLMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIY 385
                          ||.    ::.:|||:::||:||:.: ..||||:|||.||:||:|||||...
Zfish   381 NGYHNKSLKVSQKTLPATESVVVFSLGLLVLPFIPATNLFFYVGFVVAERVLYIPSMGFCLLVTA 445

  Fly   386 G----FLYWYDSSTENTHWRTALRIL---LMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDN 443
            |    |:.....|     :|..|...   |:||:|:..||..|   ||.:||.|::|.:.|.|
Zfish   446 GVRSLFVRCRSKS-----FRALLLTCTAGLVLLYSLKTVRRNQ---DWKSEEMLYRSGIAVNP-- 500

  Fly   444 AKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAY 508
            ||...|:..:..:.|...:|.:.|..|:....|....|.|||.|.:|:.:.|.|..|.:||:.:.
Zfish   501 AKAWGNLGNVLKNQGKMAEAERAYRNALYYRGNMADMLYNLGLLLQENERFSEALHYYKLAIGSR 565

  Fly   509 PAFPAAWMNLGIVQSAQGKYDKALASY-------EKALK----YRANFAVCYYNMGNLYLEQKRY 562
            |...:|::|:||:..:||..::|..::       ::.||    ::::...|.||:|.|..:|.::
Zfish   566 PTLASAYLNVGIILVSQGNIEEAKRTFHTCADIPDENLKDPHAHKSSVTSCLYNLGKLLHDQGQH 630

  Fly   563 AEALHHWQHAVALNPRQ--PKAWANIL-----------------------------------TML 590
            .|||..::.||...|||  |::..|::                                   .:|
Zfish   631 EEALSVYKEAVRKMPRQFAPQSLYNMMGEAYMRLNILEEAGHWYRESLKAKPDHIPAHLTYGKLL 695

  Fly   591 DNKGLQDDALRISNQALQHLP----------------------------------NDVSILFIRA 621
            ...|.:.:|.|...:|::..|                                  .:..::|..|
Zfish   696 SIMGQKSEAERYFLKAIELDPARGNCYMHYGQFLLEESRLAEAAAMAQKAAELDNEEFDVVFSAA 760

  Fly   622 NVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTAR 686
            ::|.:.....|||..|.:..:|.|.:.....|||.:.|...|.:||...|..|:.:......| :
Zfish   761 HMLRQASLNEEAETYYGKAADLRPDHPAALMNLGAILHLNGKLKEAESNYLRALQLKPDDLIT-Q 824

  Fly   687 ENLSKLLKRLERE 699
            .||.||...::::
Zfish   825 SNLHKLWNVMQKQ 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	30/73 (41%)
		TPR	442..701	CDD:223533	74/340 (22%)
		TPR_1	444..477	CDD:278916	7/32 (22%)
		TPR repeat	444..472	CDD:276809	7/27 (26%)
		TPR_17	466..499	CDD:290167	11/32 (34%)
		TPR repeat	480..506	CDD:276809	11/25 (44%)
		TPR repeat	511..541	CDD:276809	9/40 (23%)
		TPR_1	512..545	CDD:278916	9/43 (21%)
		TPR_1	546..577	CDD:278916	11/30 (37%)
		TPR repeat	546..574	CDD:276809	10/27 (37%)
		TPR repeat	580..608	CDD:276809	7/62 (11%)
		TPR repeat	614..642	CDD:276809	7/27 (26%)
		TPR repeat	647..677	CDD:276809	9/29 (31%)
tmtc2a	NP_001124075.1	DUF1736	254..328	CDD:285594	30/73 (41%)
		TPR_11	501..562	CDD:290150	18/60 (30%)
		TPR repeat	501..529	CDD:276809	7/27 (26%)
		TPR_1	501..>528	CDD:278916	6/26 (23%)
		TPR repeat	534..564	CDD:276809	11/29 (38%)
		TPR_1	535..>562	CDD:278916	10/26 (38%)
		TPR_12	565..642	CDD:290160	20/76 (26%)
		TPR repeat	569..597	CDD:276809	7/27 (26%)
		TPR repeat	603..642	CDD:276809	12/38 (32%)
		TPR_2	617..646	CDD:285020	10/28 (36%)
		TPR_11	653..716	CDD:290150	6/62 (10%)
		TPR repeat	653..679	CDD:276809	1/25 (4%)
		TPR repeat	684..714	CDD:276809	5/29 (17%)
		TPR_8	685..716	CDD:289924	5/30 (17%)
		TPR_16	757..820	CDD:290168	18/62 (29%)
		TPR_1	787..820	CDD:278916	9/32 (28%)
		TPR repeat	787..815	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820