DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and tmtc4

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001166973.1	Gene:	tmtc4 / 560605	ZFINID:	ZDB-GENE-070912-148	Length:	739	Species:	Danio rerio

Alignment Length:	749	Identity:	286/749 - (38%)
Similarity:	406/749 - (54%)	Gaps:	85/749 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFWGASLLSS 74
            |||.:..|.:.|||.:    ....| .|||||:.||:.|:|:|. .|..:.|:.:||||::|.|:
Zfish    20 LHSRLTTAFVALICFI----NSYDG-DFVFDDSEAIINNKDLNP-DTPLSNIWKNDFWGSNLSSN 78

  Fly    75 DSHKSFRPLTTLMFHCEYALL-GLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWA--- 135
            .||||:||||.|.|...|.|. ||.......||:.||||.::||..:...|....|...:.|
Zfish    79 SSHKSYRPLTVLTFRINYLLAGGLHPVGFHVLNVALHCVISVLMIDVFAILIGGPVQDGKGAKLS 143

  Fly   136 ------ILSAALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLGPQTGG------- 187
                  .|:|..|||||:|||:|:|:||||:|:..:...|..|:...     ..|.||
Zfish   144 LPPKASFLAALFFAAHPVHTESVAGIVGRADLLCALFFQLSFLVYCK-----AFQVGGDKKFSVL 203

  Fly   188 ---LIMLLTAVGMLFKESAVT---------IPMSCVLLDYFQNGYYHLRFK--------DQWSLL 232
               ..:||.||.||.||..:|         |.|.|.|      ..|.|..:        |...|.
Zfish   204 WIFGSILLCAVAMLCKEQGITALGVNAAYDILMVCNL------NIYELAHRLLSRRKSADIGGLP 262

  Fly   233 RT----RISYLFYLLGTLGLLTARLWWQDFET--PTFKEVDNPVAHNEHVLTRGLSQQYLLVMNI 291
            |.    |::.|| |.|:|.:.|.   |:...|  |:|.|||||.:..|:::.|.::..|...:|.
Zfish   263 RNGLLMRLALLF-LGGSLLMYTR---WKIMGTGPPSFTEVDNPASFAENIILRIVNYNYYYSLNA 323

  Fly   292 WLMLCPHWLCYDWALGCVKLVTNIWDLRL--QGVIGFYSIVLV--ALM----NFRRLPGMMLALG 348
            ||:|||.|||:||::|||.|:::..|.|:  ..|:.|..|.||  ||.    |.||.  :...|.
Zfish   324 WLLLCPWWLCFDWSMGCVPLISSAADWRIVWPAVLWFCLIGLVSQALFSQDSNKRRT--LTFGLV 386

  Fly   349 LMIVPFLPASGIIC-VGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRIL---LM 409
            |:::||||||.:.. ||||||||.||:.|.|:||:..|...|.      :.|||...|:|   .:
Zfish   387 LLVIPFLPASNVFFRVGFVIAERVLYLSSAGYCLILAYAVGYC------SCHWRKHKRLLRAATL 445

  Fly   410 LLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELY 474
            .|..|.:.|:.||:..|.:|:.||.|||.|||.|||||||:.:...|.||.:.|.|:|..|:.|:
Zfish   446 TLLCVNVTRSAQRSQQWRSEQSLFTSALSVCPLNAKVHYNVGKNLADRGNQSAAVQYYREAVRLH 510

  Fly   475 PNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKAL 539
            |.|..|:.||||:.:|..:|..|||.:..|:...|.|.||||||||||::..|::||..||..|:
Zfish   511 PKYVHAMNNLGNILKERNELKEAEELLSAAVHIQPDFAAAWMNLGIVQNSLKKFNKAEQSYWNAI 575

  Fly   540 KYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRISN 604
            ::|..:..||||:|.||.:..|..:||:.|::|..|.|....||.|::.:|||.|....|..|..
Zfish   576 RFRKKYPDCYYNLGRLYADLNRSIDALNAWRNATMLKPDHSLAWNNMVILLDNTGNLAQAELIGK 640

  Fly   605 QALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIE 669
            :||:.||.|.:|:|..||||||.:.|.|:|..:...:::.|:....|.||.||||||.|...|..
Zfish   641 EALKILPKDHTIMFSLANVLGKQEKYKESEGFFLNALKINPNVASCHGNLAVLYHRWGKLDLAKR 705

  Fly   670 AYRTAISISAARATTARENLSKLLKRLEREAQVM 703
            .|..::.:..: |...:||.:.|.::||:..:.:
Zfish   706 HYELSLRLDPS-APGTKENYNMLKRKLEQRQRTV 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	31/76 (41%)
		TPR	442..701	CDD:223533	105/258 (41%)
		TPR_1	444..477	CDD:278916	15/32 (47%)
		TPR repeat	444..472	CDD:276809	13/27 (48%)
		TPR_17	466..499	CDD:290167	13/32 (41%)
		TPR repeat	480..506	CDD:276809	11/25 (44%)
		TPR repeat	511..541	CDD:276809	17/29 (59%)
		TPR_1	512..545	CDD:278916	17/32 (53%)
		TPR_1	546..577	CDD:278916	13/30 (43%)
		TPR repeat	546..574	CDD:276809	12/27 (44%)
		TPR repeat	580..608	CDD:276809	10/27 (37%)
		TPR repeat	614..642	CDD:276809	11/27 (41%)
		TPR repeat	647..677	CDD:276809	12/29 (41%)
tmtc4	NP_001166973.1	DUF1736	291..363	CDD:312047	29/71 (41%)
		TPR	479..716	CDD:223533	99/236 (42%)
		TPR repeat	480..508	CDD:276809	13/27 (48%)
		TPR repeat	513..543	CDD:276809	12/29 (41%)
		TPR repeat	548..576	CDD:276809	16/27 (59%)
		TPR repeat	582..608	CDD:276809	11/25 (44%)
		TPR repeat	618..644	CDD:276809	10/25 (40%)
		TPR repeat	649..679	CDD:276809	12/29 (41%)
		TPR repeat	684..712	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9226
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32796
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1603
OMA	1	1.010	-	-		QHG52291
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0006261
OrthoInspector	1	1.000	-	-		oto41002
orthoMCL	1	0.900	-	-		OOG6_105345
Panther	1	1.100	-	-	LDO	PTHR44227
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2852
SonicParanoid	1	1.000	-	-		X4542
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870