DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and tmtc1

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_001922025.3	Gene:	tmtc1 / 555449	ZFINID:	ZDB-GENE-070705-219	Length:	872	Species:	Danio rerio

Alignment Length:	789	Identity:	252/789 - (31%)
Similarity:	375/789 - (47%)	Gaps:	121/789 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLPTNWTAIFTHDFWGASLLSSDSHKSFR 81
            |.||.:|.|||. ..|.| :||.||..||..|.||.. .::..:|||:||||..:..:.||||:|
Zfish    35 AALVAVCALCYS-NSLWG-EFVHDDIWAITNNPDVKP-GSSLRSIFTNDFWGKRMADNTSHKSYR 96

  Fly    82 PLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNT-LLMWRLIRSLYVPEVSTARWAILSAALFAAH 145
            ||..|.|.....|.||:......:|:.||||.| |||:...:.::    ..:.::.|:|.||:.|
Zfish    97 PLCILTFKLNILLGGLTPFFFHLVNVFLHCVVTALLMYTCQQCVF----EDSNFSFLTALLFSVH 157

  Fly   146 PIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGRLG-----PQTG-----GLIMLLTAVGMLFK 200
            |||||||||:||||:::..|:.||..|..:.:...:.     |.|.     .|.:||....||.|
Zfish   158 PIHTEAVSGIVGRADVLASMLFLLAFLSYIRSVSPIRSADEFPPTVCVWSLALSLLLGTCAMLVK 222

  Fly   201 ESAVTIPMSCVLLDYF----QNGYYHL---RFKDQWSLLRTRISYLF------YLLGTLGLLTAR 252
            |:.||:...|||.|:.    :....||   |.|:     ..|||..|      ..|....:::.|
Zfish   223 ETGVTVFGVCVLYDFLVLCRKPLILHLSRSRLKE-----LGRISSPFVKRACVVSLHVTVIMSVR 282

  Fly   253 LWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWD 317
            ||......|.|.|.|||.:.:.::|||.|:..|||..|.||:|.|..|||||.:|.:.||.::||
Zfish   283 LWLMGGSMPLFSEQDNPASFSPYLLTRFLTYCYLLAFNAWLLLAPIMLCYDWQVGSIPLVESLWD 347

  Fly   318 LRLQGVIGFYSIVLVALMN----FRRLPGMMLALGL--MIVPFLPASGIIC-VGFVIAERTLYVP 375
            .|....:....::|...:|    .:::.|..:.:||  ::.||:|||.:.. ||||:|||.||:|
Zfish   348 GRNIASLTLALVMLALSLNCVTCLQKMKGKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMP 412

  Fly   376 SIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVC 440
            |:|:|:|.::|....|  |..:.....||.:.::::..:...:|.|:...||:.|.||:|.:|..
Zfish   413 SMGYCILVVHGLNRLY--SVVSRWGAAALTVSMLVVLLLFSWKTVQQNEIWLSREALFRSGIQTL 475

  Fly   441 PDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLAL 505
            |.|||||||.|....|.|.|.:|..||..|:.|||.:.|||.|||.|..   |...||.|.|.||
Zfish   476 PHNAKVHYNYANFLKDKGRNQEAIYHYKTALRLYPRHASALNNLGTLTH---QAEEAEVYYRRAL 537

  Fly   506 QAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYAEA----- 565
            ...|....|..|||.:..:|||.::|....::::::..:||..|.::.:||.:|....||
Zfish   538 DINPQHNRALFNLGNLLKSQGKEEEAERMLKESIRFGPHFADAYSSLASLYADQGHSKEANEIYT 602

  Fly   566 -----------LH------------------HWQHAVALNP-------------------RQPKA 582
                       ||                  |:|.||.|.|                   ::.:.
Zfish   603 KGIENCPESSDLHNNYGVFLVDTGRGDRAAFHYQEAVRLKPAHYVAMVNLGRLLRSSNDNKEAEL 667

  Fly   583 W----------ANILTMLD----NKGLQDDALRISNQALQHLPNDVSILFIRANVLGKLKHYTEA 633
            |          .:|||.|.    |.|..::||.:..:|....|:...|....|.||......|||
Zfish   668 WYKRALQVVRKVDILTPLGALYYNTGRYEEALEVYREASTLQPDSTDIWLALAQVLAMAGRSTEA 732

  Fly   634 EAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARE------NLSKL 692
            |.:...:|....:....:..|..:|.:.....||::|.:||:...::......|      |..:.
Zfish   733 EKMTLGIISKTSNCIECYRLLSAIYSKQGNHTEALDALKTALQQESSEPAVRAELHFSMGNQLRE 797

  Fly   693 LKRLEREAQ 701
            :..|:|..|
Zfish   798 MNELDRAFQ 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	29/72 (40%)
		TPR	442..701	CDD:223533	88/331 (27%)
		TPR_1	444..477	CDD:278916	17/32 (53%)
		TPR repeat	444..472	CDD:276809	14/27 (52%)
		TPR_17	466..499	CDD:290167	15/32 (47%)
		TPR repeat	480..506	CDD:276809	12/25 (48%)
		TPR repeat	511..541	CDD:276809	8/29 (28%)
		TPR_1	512..545	CDD:278916	8/32 (25%)
		TPR_1	546..577	CDD:278916	14/64 (22%)
		TPR repeat	546..574	CDD:276809	12/61 (20%)
		TPR repeat	580..608	CDD:276809	10/41 (24%)
		TPR repeat	614..642	CDD:276809	8/27 (30%)
		TPR repeat	647..677	CDD:276809	7/29 (24%)
tmtc1	XP_001922025.3	DUF1736	287..361	CDD:285594	29/73 (40%)
		TPR_11	478..541	CDD:290150	32/65 (49%)
		TPR_2	479..512	CDD:285020	17/32 (53%)
		TPR repeat	479..507	CDD:276809	14/27 (52%)
		TPR repeat	512..539	CDD:276809	14/29 (48%)
		TPR_17	532..565	CDD:290167	13/32 (41%)
		TPR repeat	544..572	CDD:276809	8/27 (30%)
		TPR_11	545..609	CDD:290150	16/63 (25%)
		TPR_11	578..643	CDD:290150	14/64 (22%)
		TPR repeat	578..606	CDD:276809	7/27 (26%)
		TPR repeat	611..641	CDD:276809	6/29 (21%)
		TPR repeat	646..674	CDD:276809	1/27 (4%)
		TPR_11	648..710	CDD:290150	10/61 (16%)
		SNAP	655..>856	CDD:305195	32/152 (21%)
		TPR repeat	661..711	CDD:276937	10/49 (20%)
		TPR_14	685..722	CDD:290164	9/36 (25%)
		TPR_19	693..756	CDD:291240	15/62 (24%)
		TPR repeat	712..742	CDD:276809	9/29 (31%)
		TPR repeat	715..760	CDD:276937	11/44 (25%)
		TPR repeat	747..775	CDD:276809	7/27 (26%)
		TPR repeat	763..814	CDD:276937	10/44 (23%)
		TPR_11	784..850	CDD:290150	5/23 (22%)
		TPR repeat	784..814	CDD:276809	5/23 (22%)
		TPR repeat	815..851	CDD:276937
		TPR repeat	819..846	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820