DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and tmtc2b

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_021323440.1	Gene:	tmtc2b / 555381	ZFINID:	ZDB-GENE-081031-100	Length:	837	Species:	Danio rerio

Alignment Length:	847	Identity:	243/847 - (28%)
Similarity:	374/847 - (44%)	Gaps:	181/847 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDS 76
            :||.|:.:|:.:      ....|.|.:||:.||..|:|:  .| |.|..||..||||..|..|.|
Zfish     5 LVCSAVALLLYV------NTLDADFCYDDSRAIKTNQDL--FPETPWINIFYDDFWGTLLTHSGS 61

  Fly    77 HKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAAL 141
            |||:|||.||.|...|||.||.......:|::|||..|    .|..||....:.:..|::|:..|
Zfish    62 HKSYRPLCTLSFRLNYALGGLDPWGYHLVNVVLHCTAT----GLFSSLSSLLLGSGCWSLLAGLL 122

  Fly   142 FAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVAN-TGRLGPQTG-GLIMLLTAVG-----MLF 199
            |||||||||||:|:||||::...:.:||.|...:.: |.|.....| ..:..|..:|     ||:
Zfish   123 FAAHPIHTEAVAGIVGRADVGAALFYLLALRCYICHCTLRTSSAHGWSWMWFLGTLGCASCSMLW 187

  Fly   200 KESAVTIPMSCVLLDYFQNGYYHLRFKDQWSLLR----TRISYLFYLLGTLG--LLTARLWWQDF 258
            ||..||:.....:.|.|.  ::.|:.:...:|.:    .|:....:|||..|  ||..||:|...
Zfish   188 KEQGVTVLAVAAIYDVFV--FHKLKLQQVPALFQKKKNLRLLLSVFLLGFWGVILLACRLYWMGN 250

  Fly   259 ETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGV 323
            :.|.|...|||.|.....|||.|:..:|..:|:||:|||..|.:||::..:.|:.:|.|.|....
Zfish   251 KPPNFSNSDNPAADCPCFLTRTLTFLFLPAINVWLLLCPDMLSFDWSMDALPLLRSIADWRNLHT 315

  Fly   324 IGFY-SIVLVALMNFRRLPG--------------------------------------------- 342
            :.|| |::.:|.......|.
Zfish   316 VAFYTSLLSLAWFGLHLYPTKSKETNGKAHHVANGKSSNGHSCSTDYENSTFYSNSVQMNGTNGT 380

  Fly   343 --------------MMLALGLMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIYGFLYWYD 392
                          ::.:|||:.:||:||:.: ..||||:|||.||:||:|:|||...|....|.
Zfish   381 VKHYSSSLPTTESLVVFSLGLLAIPFIPATNLFFYVGFVVAERVLYIPSMGYCLLVALGMRCLYV 445

  Fly   393 SSTENTHWRTAL---RILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLA 454
            .....:. ||.:   ...|:|||.   ::|..|..||.|||.|:||.:.|.|  ||...|:..:.
Zfish   446 RLRRKSS-RTLVLGCSAALVLLFG---IKTVLRNRDWQNEEMLYKSGISVNP--AKAWGNLGNVL 504

  Fly   455 TDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLG 519
            .:.|...:|.|.|..|:....|....|.|||.|.:|:.:.|.|..|.:||:.:.|...:|::|.|
Zfish   505 KNQGKVEEAEQAYRNALYYRRNMADMLYNLGLLLQENSRFSEALHYYKLAIGSRPTLASAYLNTG 569

  Fly   520 IVQSAQGKYDKALASY-------EKALK----YRANFAVCYYNMGNLYLEQKRYAEALHHWQHAV 573
            ||...||:.::|..::       ::.||    ::::...|.||:|.|..||....||:..::.|:
Zfish   570 IVLMNQGRLEEAKRTFVTCAEISDENLKDPHAHKSSVTSCLYNLGKLLHEQGHQEEAISVYKEAI 634

  Fly   574 ALNPRQ--PKA--------------------------------------WANILTM--------- 589
            ...|||  |::                                      :..:|.|
Zfish   635 QKMPRQFAPQSLYNMMGEAFMRLNKLTEAEHWYKESLRAKPDHIPAHLTYGKLLAMTGQKTEAEK 699

  Fly   590 -------LD-NKG----------LQD----DALRISNQALQHLPNDVSILFIRANVLGKLKHYTE 632
                   || .||          |::    :|..::.:|.|....:..::|..|::|.:......
Zfish   700 FFLKAIELDPTKGNCYMHYGQFLLEESRLLEAAEMAEKAAQLDTEEFDVVFSAAHMLRQASLNDA 764

  Fly   633 AEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKLLKRLE 697
            ||..|::...|.|:......|||.:.|...|.|||...|..|:.:. ...|..:.||.||...:|
Zfish   765 AEKYYRQAASLRPNYPAALMNLGAILHLNGKLQEAEANYLRALQLK-PDDTITQSNLRKLWNIME 828

  Fly   698 RE 699
            ::
Zfish   829 KQ 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	27/73 (37%)
		TPR	442..701	CDD:223533	79/340 (23%)
		TPR_1	444..477	CDD:278916	8/32 (25%)
		TPR repeat	444..472	CDD:276809	8/27 (30%)
		TPR_17	466..499	CDD:290167	11/32 (34%)
		TPR repeat	480..506	CDD:276809	11/25 (44%)
		TPR repeat	511..541	CDD:276809	10/40 (25%)
		TPR_1	512..545	CDD:278916	10/43 (23%)
		TPR_1	546..577	CDD:278916	10/30 (33%)
		TPR repeat	546..574	CDD:276809	10/27 (37%)
		TPR repeat	580..608	CDD:276809	10/96 (10%)
		TPR repeat	614..642	CDD:276809	6/27 (22%)
		TPR repeat	647..677	CDD:276809	10/29 (34%)
tmtc2b	XP_021323440.1	DUF1736	250..323	CDD:312047	27/72 (38%)
		TPR	482..713	CDD:223533	56/232 (24%)
		TPR repeat	494..522	CDD:276809	8/27 (30%)
		TPR repeat	527..557	CDD:276809	11/29 (38%)
		TPR repeat	562..585	CDD:276809	8/22 (36%)
		TPR repeat	609..635	CDD:276809	10/25 (40%)
		TPR repeat	640..673	CDD:276809	2/32 (6%)
		TPR_11	<644..824	CDD:330823	32/180 (18%)
		TPR repeat	678..706	CDD:276809	2/27 (7%)
		TPR repeat	780..808	CDD:276809	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920