Protein Alignment Tmtc4 and tmtc2b

DIOPT Version :10

• Sequence 1: NP_650451.1
• Gene: Tmtc4 / 41867
• FlyBaseID: FBgn0038324
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_021323440.2
• Gene: tmtc2b / 555381
• ZFINID: ZDB-GENE-081031-100
• Length: 837
• Species: Danio rerio
• Alignment Length: 856
• Identity: 244/856 - (28%)
• Similarity: 372/856 - (43%)
• Gaps: 199/856 - (23%)

  Fly    13 MVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDS 76
            :||.|:.:|:.:      ....|.|.:||:.||..|:|:  .| |.|..||..||||..|..|.|
Zfish     5 LVCSAVALLLYV------NTLDADFCYDDSRAIKTNQDL--FPETPWINIFYDDFWGTLLTHSGS 61

  Fly    77 HKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAAL 141
            |||:|||.||.|...|||.||.......:|::|||..|    .|..||....:.:..|::|:..|
Zfish    62 HKSYRPLCTLSFRLNYALGGLDPWGYHLVNVVLHCTAT----GLFSSLSSLLLGSGCWSLLAGLL 122

  Fly   142 FAAHPIHTEAVSGVVGRAELMFGMIHLL--------CLLLTVAN--------TGRLGPQTGGLIM 190
            |||||||||||:|:||||::...:.:||        |.|.|.:.        .|.||
Zfish   123 FAAHPIHTEAVAGIVGRADVGAALFYLLALRCYIRHCTLRTSSAHGWSWMWFLGTLG-------- 179

  Fly   191 LLTAVGMLFKESAVTIPMSCVLLDYFQNGYYHLRFKDQWSLLR----TRISYLFYLLGTLG--LL 249
             ..:..||:||..||:.....:.|.|.  ::.|:.:...:|.:    .|:....:|||..|  ||
Zfish   180 -CASCSMLWKEQGVTVLAVAAIYDVFV--FHKLKLQQVPALFQKKKNLRLLLSVFLLGFWGVILL 241

  Fly   250 TARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTN 314
            ..||:|...:.|.|...|||.|.....|||.|:..:|..:|:||:|||..|.:||::..:.|:.:
Zfish   242 ACRLYWMGNKPPNFSNSDNPAADCPCFLTRTLTFLFLPAINVWLLLCPDMLSFDWSMDALPLLRS 306

  Fly   315 IWDLRLQGVIGFY-SIVLVALMNFRRLPG------------------------------------ 342
            |.|.|....:.|| |::.:|.......|.
Zfish   307 IADWRNLHTVAFYTSLLSLAWFGLHLYPTKSKETNGKAHHVANGKSSNGHSCSTDYENSTFYSNS 371

  Fly   343 -----------------------MMLALGLMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLS 383
                                   ::.:|||:.|||:||:.: ..||||:|||.||:||:|:|||.
Zfish   372 VQMNGTNGTVKHYSSSLPTTESLVVFSLGLLAVPFIPATNLFFYVGFVVAERVLYIPSMGYCLLV 436

  Fly   384 IYGFLYWYDSSTENTHWRTAL---RILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAK 445
            ..|....|......:. ||.:   ...|:|||.   ::|..|..||.|||.|:||.:.|.|  ||
Zfish   437 ALGMRCLYVRLRRKSS-RTLVLGCSAALVLLFG---IKTVLRNRDWQNEEMLYKSGISVNP--AK 495

  Fly   446 VHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPA 510
            ...|:..:..:.|...:|.|.|..|:....|....|.|||.|.:|:.:.|.|..|.:||:.:.|.
Zfish   496 AWGNLGNVLKNQGKVEEAEQAYRNALYYRRNMADMLYNLGLLLQENSRFSEALHYYKLAIGSRPT 560

  Fly   511 FPAAWMNLGIVQSAQGKYDKALASY-------EKALK----YRANFAVCYYNMGNLYLEQKRYAE 564
            ..:|::|.|||...||:.::|..::       ::.||    ::::...|.||:|.|..||....|
Zfish   561 LASAYLNTGIVLMNQGRLEEAKRTFVTCAEISDENLKDPHAHKSSVTSCLYNLGKLLHEQGHQEE 625

  Fly   565 ALHHWQHAVALNPRQ--PKA--------------------------------------WANILTM 589
            |:..::.|:...|||  |::                                      :..:|.|
Zfish   626 AISVYKEAIQKMPRQFAPQSLYNMMGEAFMRLNKLTEAEHWYKESLRAKPDHIPAHLTYGKLLAM 690

  Fly   590 ----------------LD-NKG----------LQD----DALRISNQALQHLPNDVSILFIRANV 623
                            || .||          |::    :|..::.:|.|....:..::|..|::
Zfish   691 TGQKTEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLLEAAEMAEKAAQLDTEEFDVVFSAAHM 755

  Fly   624 LGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTAREN 688
            |.:......||..|::...|.|:......|||.:.|...|.|||...|..|:.:. ...|..:.|
Zfish   756 LRQASLNDAAEKYYRQAASLRPNYPAALMNLGAILHLNGKLQEAEANYLRALQLK-PDDTITQSN 819

  Fly   689 LSKLLKRLERE 699
            |.||...:|::
Zfish   820 LRKLWNIMEKQ 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc4	NP_650451.1	TMTC_DUF1736	258..331	CDD:462468	27/73 (37%)
		LapB	431..675	CDD:442196	77/325 (24%)
		TPR repeat	444..472	CDD:276809	8/27 (30%)
		TPR repeat	480..506	CDD:276809	11/25 (44%)
		TPR repeat	511..541	CDD:276809	10/40 (25%)
		TPR repeat	546..574	CDD:276809	10/27 (37%)
		TPR repeat	580..608	CDD:276809	10/96 (10%)
		TPR repeat	614..642	CDD:276809	6/27 (22%)
		TPR repeat	647..677	CDD:276809	10/29 (34%)
tmtc2b	XP_021323440.2	None