DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and Tmtc1

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_038964827.1	Gene:	Tmtc1 / 362465	RGDID:	1564868	Length:	942	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	254/780 - (32%)
Similarity:	378/780 - (48%)	Gaps:	148/780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDVN-SLPTNWTAIFTHDFWGASLLSSDSHKSF 80
            |:|.....|||| ..|.| :||.||..|||.|.||. ..|..| |:|.:||||..|..|.||||:
  Rat    30 ALLTGASCLCYG-RSLRG-EFVHDDVWAIVNNPDVRPGAPLRW-AVFANDFWGKGLADSTSHKSY 91

  Fly    81 RPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTL-LMWRLIRSLYVPEVSTARWAILSAALFAA 144
            |||..|.|.....|.|::..:...:|::|||:.|| ||:...::::    .....|.::|.|||.
  Rat    92 RPLCVLSFRLNIFLTGMNPFYFHAVNVILHCLVTLVLMYTCDKTVF----KNRGLAFVTALLFAV 152

  Fly   145 HPIHTEAVSGVVGRAELMFGMIHLLCLL-----LTVANTGRLGPQTGGLIMLLTAV-----GMLF 199
            ||:|||||:|:||||:::..::.||..|     |.....|:..|.|.....||.::     .||.
  Rat   153 HPVHTEAVAGIVGRADVLACLLFLLAFLSYHRSLDQDCAGQCFPPTASPFFLLLSLFLGTCAMLV 217

  Fly   200 KESAVTIPMSCVLLDYF-----------------------------QNGYYHLRFKDQ------- 228
            ||:.||:...|::.|.|                             |..:.|...:.|
  Rat   218 KETGVTVFGVCLVYDLFSPSHKQDKLSNGAICQHSPRQPGSPQPSSQQAHPHRESRKQRFPHRDT 282

  Fly   229 ------------------------WSLLR-----TRISYLFYLLGTLG-----------LLTARL 253
                                    |||:|     :..|:|..|...|.           :|..||
  Rat   283 WGGCHSPLPPEPKSSGFPVSPRALWSLMRCLTGNSNRSFLLTLRPFLKRAILVISYVTVILYFRL 347

  Fly   254 WWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDL 318
            |......|.|.|.|||.:.:.::|||.|:..|||..|:||:|.|..|||||.:|.:.||..|||:
  Rat   348 WIMGGTMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPITLCYDWQVGSIPLVETIWDV 412

  Fly   319 R------LQGVIGFYSIVLVALMNFRRLPGMMLALGL--MIVPFLPASGIIC-VGFVIAERTLYV 374
            |      |..|:...|:..||.  |:||....:..||  ::.||:|||.:.. ||||:|||.||:
  Rat   413 RNLATILLAVVMALLSLHCVAA--FKRLEHKEVLAGLLFLVFPFIPASNLFFRVGFVVAERVLYM 475

  Fly   375 PSIGFCLLSIYGF------LYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLF 433
            ||:|:|:|.::|.      |....:::     ..|..:||:||||...|:..:   .||:.|.||
  Rat   476 PSMGYCILFVHGLSKLCAGLSRCGATS-----LMASTVLLLLLFSWKTVKQNE---IWLSRESLF 532

  Fly   434 KSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAE 498
            :|.:|..|.|||||||.|....|.|.|.:|..||..|::|||.:.|||.|||.|.::   ::.|:
  Rat   533 RSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYKTALKLYPRHASALNNLGTLTKD---MAEAK 594

  Fly   499 EYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCYYNMGNLYLEQKRYA 563
            .|.:.|||.:|....|..|||.:..:|.|.::|:...::::||..:||..|.::.:|..||:|:.
  Rat   595 MYYQRALQLHPQHNRALFNLGNLLKSQEKTEEAIVLLKESIKYGPDFADAYSSLASLLAEQERFK 659

  Fly   564 EALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRISNQALQHLP-NDVSILFIRANVLGKL 627
            ||...:|..:...|.......|....|.:.|..:.|:....||:|..| :.|:::     .||:|
  Rat   660 EAEDVYQAGIKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVV-----NLGRL 719

  Fly   628 K----HYTEAEAIYKRVIE-------LEPHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISISAAR 681
            .    ..:.||..|:|.::       |.|        ||.||:...:.:||:|.||.|:|:..::
  Rat   720 HRSLGENSMAEEWYRRALQVARTAEVLSP--------LGALYYNTGRHKEALEVYREAVSLQPSQ 776

Fly 682 681
Rat 777 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	33/78 (42%)
		TPR	442..701	CDD:223533	80/252 (32%)
		TPR_1	444..477	CDD:278916	17/32 (53%)
		TPR repeat	444..472	CDD:276809	14/27 (52%)
		TPR_17	466..499	CDD:290167	14/32 (44%)
		TPR repeat	480..506	CDD:276809	9/25 (36%)
		TPR repeat	511..541	CDD:276809	7/29 (24%)
		TPR_1	512..545	CDD:278916	9/32 (28%)
		TPR_1	546..577	CDD:278916	9/30 (30%)
		TPR repeat	546..574	CDD:276809	9/27 (33%)
		TPR repeat	580..608	CDD:276809	6/27 (22%)
		TPR repeat	614..642	CDD:276809	8/31 (26%)
		TPR repeat	647..677	CDD:276809	10/29 (34%)
Tmtc1	XP_038964827.1	DUF1736	352..425	CDD:400627	32/72 (44%)
		PEP_TPR_lipo	<529..942	CDD:274350	86/264 (33%)
		TPR repeat	543..571	CDD:276809	14/27 (52%)
		TPR repeat	576..603	CDD:276809	11/29 (38%)
		TPR repeat	608..636	CDD:276809	7/27 (26%)
		TPR repeat	642..670	CDD:276809	9/27 (33%)
		TPR repeat	675..705	CDD:276809	6/29 (21%)
		TPR repeat	710..738	CDD:276809	8/32 (25%)
		TPR repeat	743..771	CDD:276809	12/35 (34%)
		TPR repeat	776..806	CDD:276809	0/1 (0%)
		TPR repeat	812..839	CDD:276809
		TPR repeat	844..878	CDD:276809
		TPR repeat	883..911	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8916
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920