DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and IFIT1

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001257856.1	Gene:	IFIT1 / 3434	HGNCID:	5407	Length:	478	Species:	Homo sapiens

Alignment Length:	538	Identity:	110/538 - (20%)
Similarity:	182/538 - (33%)	Gaps:	173/538 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 RFKDQWSLLRTRISYLFYLLGTLGLL--TARLWWQDFET-PTFKEVDNPV--AHNEHVLTRGL-- 281
            |..||...|.|:     |.:|...||  ...|..|:.|. .:.||.:|.:  .|:.....|.|
Human    38 RVLDQIEFLDTK-----YSVGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVT 97

  Fly   282 ----------------SQQYL-LVMNI---------WLMLCPHWLCYD-WALGCVKLVTNIWDLR 319
                            :|.|| .|.||         :.|.||...|.: |||           |:
Human    98 WGNFAWMYYHMGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWAL-----------LK 151

  Fly   320 LQGVIGFYSIVLVALMNFRRLPGMMLALGLMIVPFLPASGIICVGFVIAERTLYVPSIGFCLLSI 384
            ..|            .|:.|.......: |.:.|..|.|.   .|:.|:...|    .||.|
Human   152 CGG------------KNYERAKACFEKV-LEVDPENPESS---AGYAISAYRL----DGFKL--- 193

  Fly   385 YGFLYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYN 449
                     :|:|..           .||::.:|                .|:::.|||..:...
Human   194 ---------ATKNHK-----------PFSLLPLR----------------QAVRLNPDNGYIKVL 222

  Fly   450 IARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAA 514
            :|....|.|...:..::...|:....:...........||..|.:..|.|.::.|||..|.....
Human   223 LALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLL 287

  Fly   515 WMNLGIVQSAQ-----------------GKYDKALAS----YEKALKYRANFAVCYYNMGNLYLE 558
            ...:|:...||                 .|.||.:.|    :|.|::.:..|.|.:.::..:|:|
Human   288 HHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIE 352

  Fly   559 QKRYAEALHHWQHAVALNP------------------RQPKAWAN-ILTMLDNKGLQDDALRISN 604
            ...:.:|..::|..:.:.|                  .|.|:..| |:..|       .|::|..
Human   353 AGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYL-------KAIKIEQ 410

  Fly   605 QALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAIE 669
            .:   |..|.||..::..||.||:         ::.::||..:.     ||.:|.......||:|
Human   411 AS---LTRDKSINSLKKLVLRKLR---------RKALDLESLSL-----LGFVYKLEGNMNEALE 458

  Fly   670 AYRTAISISAARATTARE 687
            .|..|:.::|....:.|:
Human   459 YYERALRLAADFENSVRQ 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	22/104 (21%)
		TPR	442..701	CDD:223533	58/286 (20%)
		TPR_1	444..477	CDD:278916	4/32 (13%)
		TPR repeat	444..472	CDD:276809	4/27 (15%)
		TPR_17	466..499	CDD:290167	5/32 (16%)
		TPR repeat	480..506	CDD:276809	6/25 (24%)
		TPR repeat	511..541	CDD:276809	9/50 (18%)
		TPR_1	512..545	CDD:278916	9/53 (17%)
		TPR_1	546..577	CDD:278916	5/30 (17%)
		TPR repeat	546..574	CDD:276809	5/27 (19%)
		TPR repeat	580..608	CDD:276809	6/28 (21%)
		TPR repeat	614..642	CDD:276809	6/27 (22%)
		TPR repeat	647..677	CDD:276809	8/29 (28%)
IFIT1	NP_001257856.1	TPR 1	52..85		9/32 (28%)
		TPR_12	54..127	CDD:290160	17/72 (24%)
		TPR repeat	54..80	CDD:276809	7/25 (28%)
		TPR 2	95..128		7/32 (22%)
		TPR repeat	97..123	CDD:276809	4/25 (16%)
		TPR repeat	128..170	CDD:276809	12/65 (18%)
		TPR 3	139..174		11/58 (19%)
		TPR 4	183..216		12/75 (16%)
		TPR repeat	216..246	CDD:276809	5/29 (17%)
		TPR 5	218..249		4/30 (13%)
		TPR 6	251..284		9/32 (28%)
		TPR repeat	252..279	CDD:276809	6/26 (23%)
		Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250	256..262		0/5 (0%)
		TPR repeat	284..335	CDD:276809	9/50 (18%)
		TPR 7	305..339		6/33 (18%)
		TPR 8	340..373		6/32 (19%)
		TPR repeat	340..367	CDD:276809	5/26 (19%)
		TPR 9	378..412		7/40 (18%)
		TPR repeat	378..407	CDD:276809	6/35 (17%)
		TPR 10	437..470		11/37 (30%)
		TPR repeat	437..465	CDD:276809	10/32 (31%)
		TPR_1	438..470	CDD:278916	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810