DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and Bbs4

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_038937022.1	Gene:	Bbs4 / 300754	RGDID:	1309134	Length:	529	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	72/289 - (24%)
Similarity:	130/289 - (44%)	Gaps:	32/289 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 SIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLFSVMMVRTRQRATDWLNEEQLFKSALQVC 440
            ::|.|    |.:|..:..:.:..|  :||::....|..:|:.:......|.....:::|.|::..
  Rat   149 NLGVC----YTYLKQFSKAQDQLH--SALQLNKHDLTYIMLGKIHLLQGDLDKAIEIYKKAVEFS 207

  Fly   441 PDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNLYREHGQLSTAEEYIRLAL 505
            |:|.::...:..|...:|...|||:|...|:...|....|::..|::.:.||....|....|:..
  Rat   208 PENTELLTTLGLLYLQLGVYQKAFEHLGNALTYDPANYKAILAAGSMMQTHGDFDVALTKYRVVA 272

  Fly   506 QAYPAFPAAWMNLGIVQSAQGKYDKALASYEKALKYRANFAVCY-----YNMGNLYLEQKRYAEA 565
            .|.|..|..|.|:|:....:.||..|::    .|| |||:...:     ||:|.::|..::||.|
  Rat   273 CAIPESPPLWNNIGMCFFGKKKYVAAIS----CLK-RANYLAPFDWKILYNLGLVHLTMQQYASA 332

  Fly   566 LHHWQHAVALNPRQPKAWANILTMLDNKGLQD---------DALRISN-QALQHLPNDVSILFIR 620
            .|....|:...|:..:.:..:...|.|  |:|         :|:|:.. ..|.:| |...:|:.:
  Rat   333 FHFLSAAINFQPKMGELYMLLAVALTN--LEDIENAKRAYVEAVRLDKCNPLVNL-NYAVLLYNQ 394

  Fly   621 ANVLGKLKHYTEAEAIYKRVIELEPHNTL 649
            ....|.|..|.|.|   |:|..|:.:|.|
  Rat   395 GEKKGALAQYQEME---KKVHFLKDNNPL 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	59/223 (26%)
		TPR_1	444..477	CDD:278916	8/32 (25%)
		TPR repeat	444..472	CDD:276809	7/27 (26%)
		TPR_17	466..499	CDD:290167	8/32 (25%)
		TPR repeat	480..506	CDD:276809	6/25 (24%)
		TPR repeat	511..541	CDD:276809	8/29 (28%)
		TPR_1	512..545	CDD:278916	11/32 (34%)
		TPR_1	546..577	CDD:278916	9/35 (26%)
		TPR repeat	546..574	CDD:276809	9/32 (28%)
		TPR repeat	580..608	CDD:276809	6/37 (16%)
		TPR repeat	614..642	CDD:276809	8/27 (30%)
		TPR repeat	647..677	CDD:276809	2/3 (67%)
Bbs4	XP_038937022.1	PEP_TPR_lipo	<31..442	CDD:274350	72/289 (25%)
		TPR repeat	77..104	CDD:276809
		TPR repeat	110..138	CDD:276809
		TPR repeat	143..173	CDD:276809	7/29 (24%)
		TPR repeat	178..205	CDD:276809	5/26 (19%)
		TPR repeat	211..238	CDD:276809	6/26 (23%)
		TPR repeat	245..273	CDD:276809	6/27 (22%)
		TPR repeat	279..307	CDD:276809	11/32 (34%)
		TPR repeat	312..342	CDD:276809	9/29 (31%)
		TPR repeat	347..375	CDD:276809	5/29 (17%)
		TPR repeat	381..406	CDD:276809	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810