DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5038 and Ifit1bl

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_220058.2	Gene:	Ifit1bl / 294090	RGDID:	1304872	Length:	473	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	59/294 - (20%)
Similarity:	117/294 - (39%)	Gaps:	61/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 DWLNEEQL--FKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIELYPNYESALMNLGNL 487
            |:.||..|  .:.|:::.|::..:...:|....|:|...:|.:|...|:...|:..:....:...
  Rat   194 DFSNEISLEPLRKAVRLNPEDPHLKVLLALKLQDLGKQDEAEKHIEEALPKIPSRNNIFGYVAKF 258

  Fly   488 YREHGQLSTAEEYIRLALQAYPAFPAAWMNLGI--------VQSAQGKYDK-------------A 531
            ||..|.:..|.|::..||:..|:.......:|:        ::.|...:.|             |
  Rat   259 YRRKGCVEEALEFLERALKTKPSSVYLHFQIGLCHKSRVFQIKEATNMHPKGKDRERADQSIRSA 323

  Fly   532 LASYEKALKYRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGL- 595
            :..:||.|..:..:...|.::..:|.|.|::.||              .:|:..:|:||.|..:
  Rat   324 IYYFEKTLDLKPTYERAYIDLAEMYAESKQFEEA--------------EEAFQKVLSMLSNLEVH 374

  Fly   596 ------------QDDALRISNQALQH----LPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELE 644
                        |...::..|.|:.|    |..:|:.:| |..:|..|:...|      |.::..
  Rat   375 MQQEIHFRYGKFQQFHMKSENIAITHYLKGLKIEVTSIF-RDKLLKALQKLAE------RRMQQN 432

  Fly   645 PHNTLYHTNLGVLYHRWDKTQEAIEAYRTAISIS 678
            .|.....:.||.:|.....|::|:..|..|:.::
  Rat   433 VHVLESLSLLGFVYRLKGDTRKAMSCYEKALRLT 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594
		TPR	442..701	CDD:223533	53/275 (19%)
		TPR_1	444..477	CDD:278916	7/32 (22%)
		TPR repeat	444..472	CDD:276809	6/27 (22%)
		TPR_17	466..499	CDD:290167	7/32 (22%)
		TPR repeat	480..506	CDD:276809	6/25 (24%)
		TPR repeat	511..541	CDD:276809	7/50 (14%)
		TPR_1	512..545	CDD:278916	7/53 (13%)
		TPR_1	546..577	CDD:278916	6/30 (20%)
		TPR repeat	546..574	CDD:276809	6/27 (22%)
		TPR repeat	580..608	CDD:276809	8/40 (20%)
		TPR repeat	614..642	CDD:276809	7/27 (26%)
		TPR repeat	647..677	CDD:276809	7/29 (24%)
Ifit1bl	XP_220058.2	TPR_12	62..132	CDD:290160
		TNFRSF	<124..>167	CDD:304602
		TPR repeat	144..174	CDD:276809
		TPR_11	214..280	CDD:290150	14/65 (22%)
		TPR repeat	214..244	CDD:276809	6/29 (21%)
		TPR repeat	282..333	CDD:276809	7/50 (14%)
		TPR repeat	338..366	CDD:276809	7/41 (17%)
		TPR repeat	371..406	CDD:276809	4/34 (12%)
		TPR repeat	412..464	CDD:276809	14/58 (24%)
		TPR_1	437..473	CDD:278916	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810