DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5038 and Tmtc2

DIOPT Version :9

Sequence 1:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_796342.2	Gene:	Tmtc2 / 278279	MGIID:	1914057	Length:	836	Species:	Mus musculus

Alignment Length:	841	Identity:	240/841 - (28%)
Similarity:	373/841 - (44%)	Gaps:	208/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AKFVFDDTVAIVKNRDVNSLP-TNWTAIFTHDFWGASLLSSDSHKSFRPLTTLMFHCEYALLGLS 98
            |.|.:||:.||..|:|:  || |.||.||.:||||..|..|.||||:|||.||.|...:|:.||:
Mouse    21 ADFCYDDSRAIKTNQDL--LPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLN 83

  Fly    99 AAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTARWAILSAALFAAHPIHTEAVSGVVGRAEL-- 161
            ......:|:|||...|.|..|..::|    :....|..::..:||:||||||||:|:||||::
Mouse    84 PWSYHLVNVLLHAAVTGLFTRFSKAL----LGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGA 144

  Fly   162 -MFGMIHLLCLLLTVANTGRLGPQTGGLIM---LLTAVGMLFKESAVTIPMSCVLLDYFQNGYYH 222
             :|.::.|||.:...:..| ...:|.|..:   |.....||:||..||:.....:.|.|.  ::.
Mouse   145 SLFFLLSLLCYIKHCSTRG-YSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSAVYDVFV--FHR 206

  Fly   223 LRFKDQWSLLRTRISYLFYLLGTLGLLT--------ARLWWQDFETPTFKEVDNPVAHNEHVLTR 279
            |:.|.....:..|.:...:|  ::.|||        |||:|...:.|:|...|||.|.::.:|.|
Mouse   207 LKMKQILPTIYKRKNLSLFL--SISLLTFWGTCLLGARLYWMGNKPPSFSNSDNPAADSDSLLAR 269

  Fly   280 GLSQQYLLVMNIWLMLCPHWLCYDWALGCVKLVTNIWDLRLQGVIGFYSIVLV------------ 332
            .|:..||...|:||:|||..|.:||::..|.|:..:.|.|....:.|||.:|:
Mouse   270 TLTFLYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGLLLLAYCGLKNPSLE 334

  Fly   333 ------ALMNFR---------------------------------------RLPG----MMLALG 348
                  ||.|.:                                       :||.    ::|:|.
Mouse   335 GECNGKALTNGKQNANGHSCHSDVEYRNSEMKPSFASKVENGIKNCVPQRTQLPSTENIVILSLS 399

  Fly   349 LMIVPFLPASGI-ICVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILLMLLF 412
            |:|:||:||:.: ..||||||||.||:||:|||||...|        ....:.:...|.|..|:|
Mouse   400 LLIIPFIPATNLFFYVGFVIAERVLYIPSMGFCLLITVG--------ARALYVKVQKRFLKSLVF 456

  Fly   413 SVMM-------VRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRA 470
            ....       |:|..|..||.|||.|::|.::|.|  ||...|:..:.......::|...|..|
Mouse   457 YATATLIVFYGVKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNA 519

  Fly   471 IELYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLGIVQSAQGKYDKALASY 535
            :....|....|.|||.|.:|:.:.:.|..|.:||:.:.|...:|::|.||:...|||.::|..::
Mouse   520 LFYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGKTEEARRTF 584

  Fly   536 EKA-------LK----YRANFAVCYYNMGNLYLEQKRYAEALHHWQHAVALNPRQ--PKAWANIL 587
            .|.       ||    ::::...|.||:|.||.||.||.|||..::.|:...||.  |::..|:
Mouse   585 LKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGRYEEALSVYREAIQKMPRHFAPQSLYNM- 648

  Fly   588 TMLDNKGLQDDALRISN---------QALQ----HLP---------------NDVSILFIRANVL 624
                   :.:..:|:|.         ::|:    |:|               ::....|::|..|
Mouse   649 -------MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKFFLKAIEL 706

  Fly   625 GKLK-----HY----------TEAEAIYKRVIELEPHNTLYHT---------------------- 652
            ...|     ||          |||..:.|:..||:  ||.:..
Mouse   707 DPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELD--NTEFDVVFNAAHMLRQASLNEAAEKYYD 769

  Fly   653 --------------NLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKLLKRLERE 699
                          |||.:.|...:.|:|...|..|:.:......| :.||.||...:|::
Mouse   770 LAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVIT-QSNLRKLWNIMEKQ 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	27/72 (38%)
		TPR	442..701	CDD:223533	80/350 (23%)
		TPR_1	444..477	CDD:278916	6/32 (19%)
		TPR repeat	444..472	CDD:276809	6/27 (22%)
		TPR_17	466..499	CDD:290167	10/32 (31%)
		TPR repeat	480..506	CDD:276809	10/25 (40%)
		TPR repeat	511..541	CDD:276809	11/40 (28%)
		TPR_1	512..545	CDD:278916	11/43 (26%)
		TPR_1	546..577	CDD:278916	14/30 (47%)
		TPR repeat	546..574	CDD:276809	14/27 (52%)
		TPR repeat	580..608	CDD:276809	4/36 (11%)
		TPR repeat	614..642	CDD:276809	10/42 (24%)
		TPR repeat	647..677	CDD:276809	10/65 (15%)
Tmtc2	NP_796342.2	DUF1736	247..321	CDD:285594	27/73 (37%)
		TPR 1	460..492		11/31 (35%)
		TPR_11	493..554	CDD:290150	16/60 (27%)
		TPR 2	493..526		6/32 (19%)
		TPR repeat	493..521	CDD:276809	6/27 (22%)
		TPR_1	493..>520	CDD:278916	5/26 (19%)
		TPR 3	527..560		11/32 (34%)
		TPR repeat	527..555	CDD:276809	10/27 (37%)
		TPR_12	557..634	CDD:290160	26/76 (34%)
		TPR repeat	560..590	CDD:276809	9/29 (31%)
		TPR 4	562..594		9/31 (29%)
		TPR repeat	595..634	CDD:276809	16/38 (42%)
		TPR 5	606..639		15/32 (47%)
		TPR_2	609..639	CDD:285020	14/29 (48%)
		ANAPC3	618..703	CDD:289650	18/92 (20%)
		TPR repeat	642..671	CDD:276809	4/36 (11%)
		TPR 6	643..676		4/40 (10%)
		TPR 7	677..710		4/32 (13%)
		TPR repeat	679..705	CDD:276809	2/25 (8%)
		TPR repeat	710..774	CDD:276809	11/65 (17%)
		TPR 8	712..744		9/33 (27%)
		TPR 9	746..778		0/31 (0%)
		TPR_19	755..822	CDD:291240	11/67 (16%)
		TPR 10	779..812		8/32 (25%)
		TPR_1	779..812	CDD:278916	8/32 (25%)
		TPR repeat	779..807	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820